Prevalence of hpv-infection and regional peculiarities of the risk factors of associated cervical diseases among the indigenous people of North Russia
Purpose. To assess the prevalence and age range of HPV infections of high oncogenic types and regional characteristics of risk factors of associated cervical diseases among women of small indigenous peoples of the North (Khanty-Mansi Autonomous Okrug – Yugra).Safarova O.A., Dikke G.B., Chegus L.A., KopotilovA.V., Bilan E.V., Ostromensky V.V., Shilova N.V., Kochev D.M., Shcherbatyh E.Yu.
Material and methods. A one-time selective population-based cross-sectional study of 299 women was conducted. Used questionnaires, research on HPV (material obtained through self-collection using Qvintip kits), STIs, microscopy and cytological examination of cervical smears.
Results. The prevalence of HPV infection with high oncogenic risk was 13% (38/299), with prevalence of types 16, 31 and 51, mainly in women aged 30 to 50 years (60.5%, 23/38). Of these, atypical intraepithelial lesions of the cervix were detected in 23.6%, including HSIL – in 10.5%. Regional features of risk factors include the presence of bacterial vaginosis in history and currently, diseases of the lower part of the genital tract of inflammatory nature, as well as high parity, a large number of sexual partners, the presence of gynecological diseases and operations on the genitals in history.
Conclusions. Among women of small indigenous peoples of the North (Khanty-Mansi Autonomous Okrug-Ugra), HPV infection does not exceed world indicators, but has regional characteristics of risk factors. Independent sampling of material for laboratory research on HPV using the Qvintip kit is promising for reaching the necessary number of people by organized screening.
Keywords
human papillomavirus
cervical cancer
atypical intraepithelial lesions of the cervix
risk factors
screening
Qvintip kit
References
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Received 31.05.2019
Accepted 21.06.2019
About the Authors
Safarova, Olga A., Ph.D., Head of the Department of Obstetrics and Gynecology, Medical Faculty, Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk. Russia, 628011, Khanty-Mansiysk, Mira str, 40. Tel.: +7 (3467) 324-588. E-mail: Shenoa@mail.ru. ORCID.org 0000-0002-3392-7940.Dikke, Galina B., MD, associate professor, Professor of the Department of Obstetrics and Gynecology with a course of reproductive medicine. Academy of Medical Education named F.I. Inozemtsev, St. Petersburg. Russia,
190013, St. Petersburg, Moscow Ave, 22, letter M. Tel.: +7 (812) 334-76-50. E-mail: galadikke@yandex.ru. ORCID.org 0000-0001-9524-8962.
Chegus, Larisa A., Ph.D., Assistant of the Department of Obstetrics and Gynecology, Medical Faculty, Khanty-Mansiysk Autonomous Okrug-Ugra Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk. Russia, 628011, Khanty-Mansiysk, ul. Mira 40. Tel.: +7 (3467) 324-588. E-mail: lchegus@mail.ru. ORCID.org 0000-0002-9698-8038.
Kopotilov, Anton V., obstetrican-gynecologist, Head of ginecological department, Beloyarsky district hospital. Russia,
628162, Russia, Beloyarsky, Barsukova Ave., 6. Тel: +7(3467) 020-842. E-mail: kopotilov_anton@mail.ru.
Bilan, Evgeny V., Deputy Head of Oncology, Management Board of the Khanty-Mansiysk Autonomous Okrug — Ugra “District Clinical Hospital”.
Russia, 628012, Tyumen region, Khanty-Mansiysk Autonomous Okrug – Yugra, Khanty-Mansiysk, ul. Kalinina, 40. Tel. +7 (3467) 390-454, +7 (902) 819-92-56.
E-mail: bilanev@okbhmao.ru
Ostromensky, Vladimir V., Ph.D., Head of the Department of Obstetrics and Gynecology with a course of reproductive medicine,
Academy of Medical Education named F.I. Inozemtsev, St. Petersburg.
Russia, 190013, St. Petersburg, Moscow Ave, 22, letter M. Tel.: 8 (812) 334-76-50, +7-911-910-52-73. E-mail: ostromenskyvv@gmail.com. ORCID.org 0000-0001-8290-5767.
Shilova, Natalya V., PhD., Director of Science at IVF center clinic chain, Moscow.
Russia, 129110, Moscow, Malaya Pereyaslavskaya str, 7, building 2. Tel. +7 (495) 215-55-44б add. 159. E-mail: nvshilova@gmail.com
Kochev, Dmitry M., CEO, ZAO «Pentkroft Farma», Moscow. Russia, 129110, Moscow, pr. Mira 68, bld. 2. Tel.: +7 (495) 788-77-46. E-mail: pentcroft@mail.ru
Shcherbatykh, Evgenia Yu., Ph.D., obstetrician-gynecologist, medical center «Smart Medicine», Moscow region.
Russia, 140140, Moscow region, Ramensky district, Udelnaya village, ul. Goryachev 36/1. Tel .: +7 (499) 707-26-56. Development Director, ZAO «Pencroft Pharma», Moscow. Russia, 129110, Moscow, Mira Ave., 68, b. 2. Tel: +7 (495) 788-77-46. E-mail: scherbatyh@ru486.ru.
For citations: O.A. Safarova, G.B. Dikke, L.A. Chegus, A.V. Kopotilov, E.V. Bilan, V.V. Ostromensky, N.V. Shilova, D.M. Kochev, E.Yu. Shcherbatyh. Prevalence of hpv-infection and regional peculiarities of the risk factors of associated cervical diseases among the indigenous people of North Russia. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (7): 103-110 (in Russian).
http://dx.doi.org/10.18565/aig.2019.7.103-110
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