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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2024№5
Epigenetic alterations in patients with...

Epigenetic alterations in patients with cervical intraepithelial neoplasia

DOI
https://dx.doi.org/10.18565/aig.2023.309

Levakov S.A., Dzhafarova M.M., Kaviladze M.G., Guseinova Sh.T., Mushkyurova D.R.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia

Despite numerous basic studies on the issues of malignant degeneration of precancerous diseases of the cervix and the widespread introduction of screening programs, mortality from cervical cancer continues to take the leading positions. Currently, there are no reliable prognostic criteria for malignancy of squamous cervical intraepithelial neoplasia (CIN).
The results of recent studies indicated that epigenetic regulation of gene expression plays a fundamental role in the pathogenesis of numerous malignant neoplasms including cervical cancer. The analysis of the literature data showed that squamous cell metaplasia in the cervical transformation zone is affected by cholinergic signaling. Acetylcholine and its receptors do not only regulate the processes of inflammation and proliferation of the normal cells, but they also play an important role in response to oncological processes by increasing the expression of certain receptor subunits, they inhibit apoptosis and increase the likelihood of metastasis. Thus, epigenetic modifications associated with dysplastic and metaplastic processes can serve as a powerful tool for risk stratification, prediction and treatment of cervical neoplasms caused by human papillomavirus (HPV).
Conclusion: The development of a panel of molecular predictors for accurate differential diagnosis of the degree of lesion, as well as identification of the risk group for the transition of dysplasia to cancer, will improve the examination algorithms and make it possible to timely initiate pathogenetic therapy in patients with HPV-associated cervical diseases.

Authors' contributions: Levakov S.A. – developing the concept and design of the study; Dzhafarova M.M., Kaviladze M.G., Guseinova Sh.T. – collecting and performing the analysis of literary data, writing the text; Mushkyurova D.R. – editing the text of the article.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
For citation: Levakov S.A., Dzhafarova M.M., Kaviladze M.G., Guseinova Sh.T., Mushkyurova D.R. 
Epigenetic alterations in patients with cervical intraepithelial neoplasia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (5): 5-12 (in Russian)
https://dx.doi.org/10.18565/aig.2023.309

Keywords

cervical intraepithelial neoplasia
LSIL
HSIL
NILM
cervical cancer
human papillomavirus
high carcinogenic risk
fertility
epigenetics
nicotine acetylcholine receptors
Full text (in Russian)

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Received 29.12.2023

Accepted 22.05.2024

About the Authors

Sergey A. Levakov, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, N.V. Sklifosovsky ICM, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), 119991, Russia, Moscow, Trubetskaya str., 8, bld. 2, +7(495)609-14-00, levakoff@yandex.ru,
https://orcid.org/0000-0002-4591-838X
Makhluga M. Dzhafarova, PhD student of the Department of Obstetrics and Gynecology, N.V. Sklifosovsky ICM, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), 119991, Russia, Moscow, Trubetskaya str., 8, bld. 2, +7(495)609-14-00, qoqlu55@mail.ru
Mariami G. Kaviladze, PhD student, Teaching Assistant at the Department of Obstetrics and Gynecology, N.V. Sklifosovsky ICM, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), 119991, Russia, Moscow, Trubetskaya str., 8, bld. 2, +7(495)609-14-00, mariam-kaviladze@mail.ru,
https://orcid.org/0000-0003-0221-5673
Shirin T. Guseynova, Student, N.V. Sklifosovsky ICM, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University),
119991, Russia, Moscow, Trubetskaya str., 8, bld. 2, +7(495)609-14-00, guseinova.shirin@mail.ru, https://orcid.org/0009-0008-6967-7497
Diana R. Mushkyurova, PhD student of the Department of Obstetrics and Gynecology, N.V. Sklifosovsky ICM, I.M. Sechenov First Moscow State Medical University,
Ministry of Health of Russia (Sechenov University), 119991, Russia, Moscow, Trubetskaya str., 8, bld. 2, +7(495)609-14-00, dr.ramazanovna@gmail.com,
https://orcid.org/0009-0007-7494-5807
Corresponding author: Mariami G. Kaviladze, mariam-kaviladze@mail.ru

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