Creating an effective system for the prevention of group B streptococcal infections in obstetrics and neonatology

DOI

https://dx.doi.org/10.18565/aig.2023.216

Grigorian I.E., Priputnevich T.V., Dolgushina N.V., Kan N.E., Nikolaeva A.V., Shabanova N.E.
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

This article describes the international experience of prevention of group B streptococcal (GBS) infections and screening programs for the prevention of GBS infection in obstetrics and neonatology. Two key national strategies have been identified: risk factor assessment and screening. Since 1996, when the first clinical guidelines for the prevention of GBS infections were first developed, risk factor assessment has been used and a number of countries, such as the United Kingdom and the Netherlands, have followed this strategy to date. Screening programs are used in the United States of America, Canada, Italy, France, Germany and, since 2020, in the Russian Federation. The national clinical guidelines specify the main stages of the algorithm for diagnosing patients to identify the carrier of group B streptococcus and prevention of mother-to-fetus transmission of the microorganism. Despite the effectiveness of the screening program, there are several limitations and inaccuracies in the national regulatory documentation, including those related to patient routing, the preanalytical stage of diagnosis and management of patients with multiple pregnancies.
The recommendations for the improvement of the national screening program were offered after the analysis of the national legal documentation regulating the prevention of GBS infections in obstetrics and neonatology.
Our analysis of the international experience and national regulatory documentation was taken into account in making updated versions of clinical recommendations and preparing practical recommendations for laboratory medicine specialists.
Conclusion: In order to resist GBS infections in obstetrics and neonatology effectively, it is necessary to develop clinical recommendations that will specify all the stages and aspects of the prevention of group B streptococcal infections in detail to reduce neonatal morbidity, disability and mortality, and increase demographic indicators.

Authors’ contributions: Grigorian I.E. – developing the concept and design of the study, conducting a literature review, data analysis, writing the text; Priputnevich T.V. – developing the concept and design of the study, data analysis, editing; Dolgushina N.V. – developing the concept and design of the study, writing the text, editing; Kan N.E. – developing the concept and design of the study, data analysis, editing; Nikolaeva A.V. – developing the concept and design of the study, editing; Shabanova N.E. – editing.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Grigorian I.E., Priputnevich T.V., Dolgushina N.V., Kan N.E., Nikolaeva A.V., Shabanova N.E. Creating an effective system for the prevention
of group B streptococcal infections in obstetrics and neonatology.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (12): 59-67 (in Russian)
https://dx.doi.org/10.18565/aig.2023.216

group B streptococcus

screening

obstetric infections

neonatal infections

healthcare

Full text (in Russian)

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Received 07.09.2023

Accepted 05.12.2023

Iren E. Grigorian, Junior Researcher, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(909)912-59-66, irengrigorian96@yandex.ru, https://orcid.org/0000-0003-4675-9568, 117997, Russia, Moscow, Ac. Oparin str., 4.
Tatiana V. Priputnevich, Corresponding Member of the RAS, Dr. Med. Sci., Associate Professor, Director of the Institute of Microbiology, Antimicrobial Therapy and Epidemiology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(910)414-56-16, priput1@gmail.com, https://orcid.org/0000-0002-4126-9730, 117997, Russia, Moscow, Ac. Oparin str., 4.
Natalia V. Dolgushina, Dr. Med. Sci., Professor, Deputy Director for Science, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, https://orcid.org/0000-0003-1116-138X, 117997, Russia, Moscow, Ac. Oparin str., 4.
Natalia E. Kan, Dr. Med. Sci., Professor, Deputy Director for Science, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,
https://orcid.org/0000-0001-5087-5946, 117997, Russia, Moscow, Ac. Oparin str., 4.
Anastasia V. Nikolaeva, Ph.D, Head Physician, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia, https://orcid.org/0000-0002-0012-6688, 117997, Russia, Moscow, Ac. Oparin str., 4.
Natalia E. Shabanova, Ph.D, Associate Professor, Head of the Department of Clinical Pharmacology of Antimicrobial and Immunobiological Agents, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, https://orcid.org/0000-0002-0012-6688,
117997, Russia, Moscow, Ac. Oparin str., 4.

Creating an effective system for the prevention of group B streptococcal infections in obstetrics and neonatology

Grigorian I.E., Priputnevich T.V., Dolgushina N.V., Kan N.E., Nikolaeva A.V., Shabanova N.E.

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