Different clinical forms of vulvovaginal candidiasis: Principles of treatment

Savchenko T.N., Nosova L.A., Shapovalova Yu.O.

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow 125367, Ivankovskoye Highway 7, Russia

Therapy for vulvovaginal candidiasis (VVC) presents certain difficulties and depends on the form of the disease and the type of its pathogen. The primary goal of its therapy is to eradicate the pathogen.
Objective. To improve treatments for different clinical forms of VVC.
Subjects and methods. A total of 105 women, including 85 patients with Candida infection a study group) and 20 healthy women (a control group), were examined. All the women underwent bacterioscopic and bacteriological examinations to detect the bacterial and Candida microflora. A Candiselect-4 diagnostic kit (Bio-Rad, USA) was used to determine yeast fungal species and concentration. The patients with Candida infection were divided into 2 groups: 1) 70 patients with Candida monoinfection; 2) 15 patients with mixed bacterial and Candida infection.
Results and discussion. All the patients received sertaconazole (zalain), a derivative of benzothiophene and imidazole, having fungistatic and fungicidal effects on fungi and antibacterial activity. The drug was administered as one 300-mg vaginal suppository weekly overnight or in combination with zalain cream
Conclusion. The investigations have indicated that sertaconazole (zalain) has a high (94%) activity against any type of vaginal candidiasis in both monoinfection and mixed Candida and bacterial infection. By acting not only on Candida albicans, but also on non-Candida albicans, the drug rapidly resolves the clinical manifestations in the acute and chronic course of the disease, which together with the absence of adverse reactions allows one to recommend its use in patients with different clinical forms of vulvovaginitis.

Keywords

Supplementary Materials

1. Table 1. Species spectrum of microorganisms isolated from the cervical canal of women in the study groups
2. Table 2. Comparative evaluation of methods of diagnosis of vulvovaginal candidiasis
3. Table 3. Clinical variants of candidal vulvovaginitis in patients of the study groups
4. Table 4. Species composition of yeast fungi of the genus Candida, isolated from the examined women
5. Table 5. Subjective symptoms of the disease in patients with candidal vulvovaginitis
6. Table 6. Systemic antimycotics for the treatment of chronic recurrent VVC (main course)

References

About the Authors

Savchenko Tatyana Nikolaevna, MD, professor of the Department of Obstetrics and Gynecology of the Faculty of Physiotherapy, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia. 125367, Russia, Moscow, Ivankovskoye Highway 7. Tel.: +79166560286. E-mail: 12111944t@mail.ru
Nosova Lilia Andreevna, 6th year student of the medical faculty, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia.
125367, Russia, Moscow, Ivankovskoye Highway 7. Tel.: +79651606754. E-mail: karelina_lilia@mail.ru
Shapovalova Yulia Olegovna, 6th year student of the Faculty of Physiotherapy, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia.
125367, Russia, Moscow, Ivankovskoye Highway 7. Tel.: +79154333396. E-mail: dr_matreshka@bk.ru

For citations: Savchenko T.N., Nosova L.A., Shapovalova Yu.O. Different clinical
forms of vulvovaginal candidiasis: Principles of treatment.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (3): 147-53. (in Russian)
http://dx.doi.org/10.18565/aig.2017.3.147-53

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