Pathogenetic parallels of tumor growth and placental pathological invasion

DOI

https://dx.doi.org/10.18565/aig.2022.5.14-22

Kayumova A.V., Melkozerova O.A., Bashmakova N.V., Malgina G.B., Chistyakova G.N.
Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation, Yekaterinburg, Russia

Objective: To study current ideas about the pathogenesis of placental pathological invasion according to Russian and foreign literature and to identify parallels between some pathogenetic mechanisms of tumor growth and placental abnormal invasion.
Materials and methods: The keywords “placenta”, “deep placental invasion”, “placenta accreta”, “implantation”, “apoptosis”, “neoangiogenesis”, “mitochondrial dysfunction”, “placenta accreta spectrum”, “placenta percreta”, “placenta increta”, “placenta accreta”, and “epithelial-mesenchymal transition” were used to search for literature sources in the Russian and foreign databases eLibrary, Medline/PubMed, Embase, and Crossref.
Results: Placental pathological invasion is considered as a multifactorial complication of gestation, which has the features of tumor growth, including abnormal neoangiogenesis, apoptosis, uncontrolled proteolysis, and escape from immunological control. The basis for these pathophysiological parallels is the phenomenon of epithelial-mesenchymal transition. The paper presents recent studies demonstrating the role of placental mitochondrial dysfunction in changing the expression of promoter genes that regulate the depth of placental invasion.
Conclusion: The parallels between some pathogenetic mechanisms of tumor growth and placental abnormal invasion, which are identified in this article, can give rise to further in-depth studies of the pathogenesis of this pregnancy complication in order to expand science knowledge of the pathophysiology of deep placenta accreta and to improve models for predicting this pathology to prevent maternal morbidity and mortality.

deep placental invasion

placenta accreta

epithelial-mesenchymal transition

implantation

apoptosis

neoangiogenesis

mitochondrial dysfunction

Full text (in Russian)

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Received 15.02.2022

Accepted 28.04.2022

Alena V. Kayumova, PhD, Leading Researcher, Head of the Medical Care Quality Control Department, Ural Research Institute of Maternity and Child Care,
Ministry of Health of the Russian Federation, +7-982-62-32-047, kaum-doc@mail.ru, https://orcid.org/0000-0003-2685-4285, 620028, Russia, Ekaterinburg, Repin str., 1.
Oksana A. Melkozerova, Dr. Med. Sci., Deputy Director for Science, Ural Research Institute of Maternity and Child Care, Ministry of Health of the Russian Federation, abolmed1@mail.ru, https://orcid.org/0000-0002-4090-0578, 620028, Russia, Ekaterinburg, Repin str., 1.
Nadezhda V. Bashmakova, Dr. Med. Sci., Professor, Chief Researcher, Ural Research Institute of Maternity and Child Care, Ministry of Health of the Russian Federation, bashmakovanv@niiomm.ru, https://orcid.org/0000-0001-5746-316X, 620028, Russia, Ekaterinburg, Repin str., 1.
Galina B. Malgina, Dr. Med. Sci., Director of the Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, galinamalgina@mail.ru,
https://orcid.org/0000-0002-5500-6296, 620028, Russia, Ekaterinburg, Repin str., 1.
Guzal N. Chistyakova, Dr. Med. Sci., Professor, Head of Research Department of Immunology and Microbiology, Ural Research Institute of Maternity and Child Care,
Ministry of Health of the Russian Federation, guzel@niiomm.ru, https://orcid.org/0000-0002-0852-6766, 620028, Russia, Ekaterinburg, Repin str., 1.
Corresponding author: Alena V. Kayumova, kaum-doc@mail.ru

Authors' contributions: Kayumova A.V., Melkozerova O.A. – concept and design of the investigation, material collection and procession; Kayumova A.V. – writing the text; Bashmakova N.V., Melkozerova O.A., Malgina G.B., Chistyakova G.N. – editing.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: State research assignment No. 056-00121-22-00.
For citation: Kayumova A.V., Melkozerova O.A.,
Bashmakova N.V., Malgina G.B., Chistyakova G.N. Pathogenetic parallels
of tumor growth and placental pathological invasion.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 5: 14-22 (in Russian)
https://dx.doi.org/10.18565/aig.2022.5.14-22

Pathogenetic parallels of tumor growth and placental pathological invasion

Kayumova A.V., Melkozerova O.A., Bashmakova N.V., Malgina G.B., Chistyakova G.N.

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