Characteristics of circadian regulation in patients with miscarriage

DOI

https://dx.doi.org/10.18565/aig.2024.95

Baroeva M.D., Datieva F.S., Popova L.S., Tsallagova L.V.
1) Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences, Vladikavkaz, Russia; 2) North Ossetian State Medical Academy, Ministry of Health of Russia, Vladikavkaz, Russia

The article presents the analysis of circadian regulation disorders contributing to miscarriage and complicating the course of pregnancy. The circadian system of the body provides regulation of the neuroendocrine-immune (NEIM) system, dynamic balance and the process of adaptation of the female body to the developing pregnancy, and fetal growth. The autonomous circadian regulation is formed in the fetus/embryo under the influence of endogenous and exogenous signals that carry information through the placenta during normal pregnancy. The transcription factor genes CLOCK/BMAL1, the light period genes Period 1-3/Cryptochrome 1-2 and their protein products play an important role in the process of circadian regulation. Mutations in genes regulating and controlling the “clock” are accompanied in experiment and clinic by the development of pathologic conditions followed by disruption of estrous cycles, failure of embryo implantation, and increased risk of miscarriage. Dysregulation of non-circadian functions of the clock genes leads to systemic endothelial dysfunction and epigenetic disorders. The disorders of circadian rhythms called desynchronoses appear when the effects of stereotypical internal (deficit and displacement of the sleeping period, typical pathological processes) and/or external (change of work schedule and time zone) environmental factors are altered.
Conclusion: Newly developed or existing disorders in the circadian organization of the maternal body may modulate a number of pathogenetic mechanisms in case of miscarriage: neurogenic, endocrine, immune, and vascular; therefore, a detailed study of the mechanisms of adaptation and integration of rhythms in the emerging multifunctional system “mother-placenta-fetus” is extremely important in obstetric practice.

Authors’ contributions: Baroeva M.D., Datieva F.S., Popova L.S., Tsallagova L.V. – developing the concept and design of the study, collecting publications for analysis, processing and analyzing the material on the topic, writing the text of the manuscript, editing the article.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The work was carried out according to the plan of R&D of the Institute of Biomedical Research, Vladikavkaz Scientific Center of the Russian Academy of Sciences.
For citation: Baroeva M.D., Datieva F.S., Popova L.S., Tsallagova L.V.
Characteristics of circadian regulation in patients with miscarriage.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (7): 5-11 (in Russian)
https://dx.doi.org/10.18565/aig.2024.95

miscarriage

circadian rhythms

clock genes

gene polymorphism

Full text (in Russian)

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Received 18.04.2024

Accepted 13.06.2024

Madina D. Baroeva, Junior Researcher at the Laboratory of Reproductology and Gestational Pathology, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences, 362027, Russia, Vladikavkaz, Pushkinskaya str., 47; PhD student at the Department of Obstetrics and Gynecology No. 1,
North Ossetian State Medical Academy, Ministry of Health of the Russian Federation, +7(918)834-48-44, vip.baroeva @mail.ru, https://orcid.org/0000-0003-3978-743X
Fatima S. Datieva, Dr. Med. Sci., Director, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences,
362027, Russia, Vladikavkaz, Pushkinskaya str., 47, +7(919)425-56-64, faaroo@mail.ru, https://orcid.org/0000-0002-1636-9174
Larisa S. Popova, PhD, Associate Professor at the Department of Obstetrics and Gynecology No. 1, North Ossetian State Medical Academy, Ministry of Health of the Russian Federation; Senior Researcher, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences, 362027, Russia, Vladikavkaz, Pushkinskaya str., 47, +7(928)069-03-06, larisa_s_popova@mail.ru, https://orcid.org/0000-0003-3546-4385
Larisa V. Tsallagova, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology No. 1, North Ossetian State Medical Academy, Ministry of Health of the Russian Federation; Head of the Laboratory of Reproductology and Gestational Pathology, Institute of Biomedical Research – branch of the Vladikavkaz Scientific Center of the Russian Academy of Sciences, 362027, Russia, Vladikavkaz, Pushkinskaya str., 47, +7(918)827-86-86, akusherstvo_1@mail.ru, https://orcid.org/0000-0003-0514-3038
Corresponding author: Madina D. Baroeva, vip.baroeva @mail.ru

Characteristics of circadian regulation in patients with miscarriage

Baroeva M.D., Datieva F.S., Popova L.S., Tsallagova L.V.

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