ISSN 0300-9092 (Print)
ISSN 2412-5679 (Online)

Phylogenetic and ontogenetic role of placenta decidua in establishing pregnancy and specific characteristics of its course

Lipatov I.S., Tezikov Yu.V., Kalinkina O.B., Kurbanova A.M., Tarasov D.O., Mikhailova E.I., Dubinsky M.R.

Samara State Medical University, Ministry of Health of Russia, Samara, Russia

The review presents the issue of development of gestational complications through the concept of defective decidualization. The main stages of the phylo- and ontogenetic development of decidua are discussed; the factors that directly or indirectly influence the decidualization process itself are also considered. The review provides a comprehensive analysis of the existing knowledge on the multifaceted functions of the placental decidua, its participation in the uteroplacental hemocirculation. It also explores the creation of an immunoprivileged and metabolically optimal environment at the border of the decidua-chorion system, which is critical for ensuring normal pregnancy. The article shows the possibilities of decidualization therapy, laboratory control of the functional state of decidua basalis and implementation of measures aimed at reducing the incidence of pre-eclampsia, placental insufficiency, fetal growth retardation, miscarriage and preterm labor.
Conclusion: Decidua plays a key role in establishing normal pregnancy, as it is the main factor in the development of gestational complications, both in the early and late stages of gestation. The effectiveness of preventive measures aimed at increasing the receptivity of the endometrium and its complete transformation in the process of decidualization makes this area particularly relevant for further study given the worldwide fertility crisis.

Authors’ contributions: Lipatov I.S., Tezikov Yu.V. – developing the concept and design of the study; Kurbanova A.M., Tarasov D.O., Mikhailova E.I., Dubinsky M.R. – search for and analysis of the material; Kalinkina O.B., Kurbanova A.M. – writing the text of the article; Lipatov I.S., Tezikov Yu.V. – editing the text.
Conflicts of interest: Authors declare lack of the possible conflicts of interest.
Funding: The study was carried out without sponsorship.
For citation: Lipatov I.S., Tezikov Yu.V., Kalinkina O.B., Kurbanova A.M., Tarasov D.O., 
Mikhailova E.I., Dubinsky M.R. Phylogenetic and ontogenetic role of placenta decidua
in establishing pregnancy and specific characteristics of its course.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (5): 20-30 (in Russian)
https://dx.doi.org/10.18565/aig.2024.328

Keywords

decidua
phylogeny
ontogeny
decidual macrophages
decidualization therapy
miscarriage
pre-eclampsia
placental insufficiency
preterm labor
delayed fetal growth

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Received 23.12.2024

Accepted 18.04.2025

About the Authors

Igor S. Lipatov, Professor, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89, +7(846)958-24-18, i.lipatoff2012@yandex.ru, Researcher ID: С-5060-2018, SPIN-код: 9625-2947, Author ID: 161371, Scopus Author ID: 6603787595, https://orcid.org/0000-0001-7277-7431
Yurii V. Tezikov, Professor, Dr. Med. Sci., Head of the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine, Samara State Medical University,
Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89, +7(846)958-24-18, yra.75@inbox.ru, Researcher ID: С-6187-2018, SPIN-код: 2896-6986,
Author ID: 161372, Scopus Author ID: 6603787595, https://orcid.org/0000-0002-8946-501X
Olga B. Kalinkina, Associate Professor, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89, +7(846)958-24-18, maiorof@mail.ru, Researher ID: I-3529-2014, SPIN-код: 1260-6181, Author ID: 335830, https://orcid.org/0000-0002-1828-3008
Aminat M. Kurbanova, Teaching Assistant at the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine, Samara State Medical University,
Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89, +7(846)958-24-18, aminca.kurbanova@mail.ru, Researcher ID: KEJ-3777-2024,
SPIN-код: 6299-0501, Author ID:1073141, https://orcid.org/0000-0002-5277-0379
Dmitrii O. Tarasov, 6th year student of the Institute of Clinical Medicine, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara,
Chapaevskaya str., 89, +7(846)958-24-18, dimatarasov12@gmail.com, Researcher ID: LWK-6027-2024, https://orcid.org/0009-0008-7381-6226
Elizaveta I. Mikhailova, 6th year student of the Institute of Clinical Medicine, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89, +7(846)958-24-18, elizaveta.mikhailova2002@mail.ru, Researcher ID: LWK-6350-2024, https://orcid.org/0009-0003-1980-2310
Maxim R. Dubinsky, 6th year student of the Institute of Clinical Medicine, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara,
Chapaevskaya str., 89, +7-846-958-24-18, dubinskiy.mr1608@mail.ru, Researcher ID: LWZ-9943-2024, https://orcid.org/0009-0004-5463-118X

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