Diagnosis of placental insufficiency by testing f or serum DcR3
Aim. To investigate serum levels of DcR3 in women with threatened miscarriage, recurrent miscarriage, and healthy pregnancy.Malyshkina A.I., Sotnikova N.Yu., Kroshkina N.V., Batrak N.V.
Materials and methods. The study comprised 75 pregnant women, including 46 patients with a threatened miscarriage before12 weeks’ gestation and recurrent miscarriage (study group) and 29 women with a first-trimester pregnancy and no signs of threatened and recurrent miscarriage (control group). The serum level of DcR3 was determined by enzyme immunoassay.
Results. Serum levels of DcR3 above 0.87 pg/ml are indicative of the development of placental insufficiency in the second half of pregnancy, both in women of the study and control groups.
Conclusion. Elevated serum DcR3 levels in early pregnancy lend support for further studies aimed at predicting placental insufficiency.
Keywords
threatened miscarriage
recurrent miscarriage
placental insufficiency
References
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Received 19.11.2019
Accepted 29.11.2019
About the Authors
Anna I. Malyshkina, MD, director Federal state budgetary institution Ivanovo research institute of motherhood and childhood of a name of V. N. Gorodkov of Ministryof health of the Russian Federation.; head department of obstetrics and gynecology, medical genetics, Federal state budgetary educational institution of higher education Ivanovo state medical academy of the Ministry of health of the Russian Federation. E-mail: ivniimid@inbox.ru
153045, Russia, Ivanovo, Pobedy St., 20; 153012, Russia, Ivanovo, Sheremetevsky Ave., 8.
Natalya Yu. Sotnikova, MD, professor, honored doctor of the Russian Federation, head of the laboratory of clinical immunology, Federal state budgetary institution Ivanovo research institute of motherhood and childhood of a name of V. N. Gorodkov of Ministry of health of the Russian Federation. department of pathophysiology and immunology, Federal state budgetary educational institution of higher education Ivanovo state medical academy of the Ministry of health of the Russian Federation.
E-mail: ivniimid@inbox.ru
153045, Russia, Ivanovo, Pobedy St., 20; 153012, Russia, Ivanovo, Sheremetevsky Ave., 8.
Natalya V. Kroshkina, Ph.D., researcher, Federal state budgetary institution Ivanovo research institute of motherhood and childhood of a name of V. N. Gorodkov
of Ministry of health of the Russian Federation. Phone: +7(980)6931822. E-mail: ivniimid@inbox.ru
153045, Russia, Ivanovo, Pobedy St., 20.
Nataliya V. Batrak, PhD, assistant to department of obstetrics and gynecology, medical genetics, Federal state budgetary educational institution of higher education Ivanovo state medical academy of the Ministry of health of the Russian Federation. Phone: +7(962)1600133. E-mail: batrakn@inbox.ru. https://orcid.org/0000-0002-5230-9961
153012, Russia, Ivanovo, Sheremetevsky Ave., 8.
For citation: Malyshkina A.I., Sotnikova N.Yu., Kroshkina N.V., Batrak N.V. Diagnosis of placental insufficiency by testing for serum DcR3.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 3: 64-70. (In Russian).
https://dx.doi.org/10.18565/aig.2020.3.64-70