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About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
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Obstetrics and Gynegology2024№7
Assessment of the potential use...

Assessment of the potential use of antioxidant support in infertility of various etiologies

DOI
https://dx.doi.org/10.18565/aig.2024.68

Berezina D.A., Karimova A.A.

Ural State Medical University, Ministry of Health of Russia, Yekaterinburg, Russia

The options for infertility treatment increase and it is necessary to assess rationally the value of including additional substances in the algorithms for the management of patients. One of the most controversial issues remains the use of antioxidants. Although these substances have a positive effect on molecular levels, the results of their use in clinical practice can be very contradictory. To obtain an up-to-date and comprehensive view of the role of antioxidants in combating oxidative stress observed in various reproductive pathologies, we reviewed the world literature sources in Scopus, Web of Science, MedLine, Cochrane and other databases for the last five years. The data on potential mechanisms of antioxidant action in relation to molecular targets in the female reproductive system were summarized and analyzed. It was observed that the majority of foreign scientists were interested in the potential use of antioxidants in the treatment of infertility associated with endocrine disorders. The review pays special attention to the analysis of experience in the use of the most widely studied antioxidants in the treatment of unexplained infertility.
Conclusion: The analysis of the literature data demonstrated the considerable potential of natural antioxidants, but in most cases their use did not result in statistically significant clinical effects, even for the molecules most studied, such as vitamins C and E, alpha-lipoic acid, L-carnitine, and melatonin. The use of antioxidants in the treatment of unexplained infertility has had disappointing results so far. Nevertheless, there is still hope for achieving this ambitious therapeutic goal which justifies the need to continue further research on this issue.

Authors’ contributions: Berezina D.A. – developing the concept of the article; editing the text; Berezina D.A., Karimova A.A. – analysis of literature data, writing the text.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Berezina D.A., Karimova A.A. Assessment of the potential use 
of antioxidant support in infertility of various etiologies.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (7): 22-27 (in Russian)
https://dx.doi.org/10.18565/aig.2024.68

Keywords

antioxidants
treatment of infertility
unexplained infertility
Full text (in Russian)

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Received 22.03.2024

Accepted 10.07.2024

About the Authors

Dinara A. Berezina, PhD student, Department of Obstetrics and Gynecology, Ural State Medical University, Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repina str., 3, +7(908)906-37-57, dinara-berezina@mail.ru, https://orcid.org/0000-0003-2797-1926
Alisa A. Karimova, PhD, Associate Professor at the Department of Pharmacy, Ural State Medical University, Ministry of Health of Russia, 620028, Russia, Yekaterinburg,
Repina str., 3, +7(950)549-29-64, otd.mspo@gmail.com, https://orcid.org/0000-0003-3500-096X
Corresponding author: Dinara A. Berezina, dinara-berezina@mail.ru

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