New technologies in gynecology: A fixed extended hormonal contraceptive regimen
Objective. To carry out a systematic analysis of the data available in the current literature on extended combined oral contraceptive regimens.Aganezova N.V., Aganezov S.S.
Material and methods. The review includes data from foreign investigations published in the past 10 years and found in Pubmed on this topic.
Results. The benefits of a 91-day fixed extended contraceptive regimen are described. The results of investigations of the efficacy, safety, and patient acceptability of a combination of ethinyl estradiol and levonorgestrel with 7-day low-dose ethinyl estradiol continuation are given. Information on a new combined contraceptive containing ethinyl estradiol and levonorgestrel is provided.
Conclusion. Further investigations are needed to improve approaches to the individualized use of hormonal contraception.
Keywords
hormonal contraception
levonorgestrel
ethinyl estradiol
fixed extended regimen
Modell Libera
gestagens
Supplementary Materials
- Table 1. Fixed prolonged regimens of COCs with levonorgestrel, approved by the FDA [5]
- Fig. 1. Estradiol levels are lower in the EE group than in the placebo group (cycle 2, day 1) [16]
- Fig. 2. FSH levels are lower in the EE group compared to the placebo group (cycle 1, day 27) [16]
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Received 07.02.2017
Accepted 17.02.2017
About the Authors
Aganezova Natalia V., MD, Associate Professor, Department of Obstetrics and Gynecology, I.I. Mechnikov North-West State Medical University,Ministry of Health of Russia. 191015, Russia, St. Petersburg, Kirochnaya str. 41. Tel.: +79219462273. Е-mail: aganezova@mail.ru
Aganezov Sergey S., PhD, Associate Professor, Department of Obstetrics and Gynecology, I.I. Mechnikov North-West State Medical University,
Ministry of Health of Russia. 191015, Russia, St. Petersburg, Kirochnaya str. 41. Tel.: +79219385073. Е-mail: aganezov@mail.ru
For citations: Aganezova N.V., Aganezov S.S. New technologies in gynecology:
A fixed extended hormonal contraceptive regimen.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (3): 154-9. (in Russian)
http://dx.doi.org/10.18565/aig.2017.3.154-9
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