A new paradigm in cervical neoplasia progression: from fundamental knowledge to practical gynecology
The mainstay of treatment for precancerous cervical neoplastic diseases caused by human papillomavirus (HPV) continues to be surgical techniques (laser destruction, loop electrosurgical excision, cryodestruction, and cold-knife conization) that are accompanied by high complication and recurrence rates and negatively affect female reproductive function. The etiopathogenetic therapy of cervical intraepithelial neoplasia (CIN), which affects the key mechanisms for the hyperproliferation and tumor transformation of HPV-infected cervical epithelial cells, is becoming increasingly important now. Cervicon-DIM is the world’s first and only 3,3’-diindolylmethane-based drug used to treat CIN, regardless of whether HPV infection is detected by PCP. Acting locally, Cervicon-DIM versus placebo stimulates apoptosis of virus-infected and -transformed cells and substantially increases the likelihood of regression of cervical dysplasia.Kiselev V.I., Muyzhnek E.L., Ashrafyan L.A., Sukhikh G.T.
Keywords
cervical intraepithelial neoplasia
CIN 1
CIN 2
CIN 3
3-3’-diindolylmethane
vaginal suppositories
medical treatment
secondary prevention of cervical cancer
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Received 30.11.2018
Accepted 07.12.2018
About the Authors
Kiselev, Vsevolod I., MD, associate academician of the Russian Academy of Sciences, Deputy of director of the Institute of Gynecoloigy and Mammology of AcademicianV.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4.Tel.: +74955314444. E-mail: vkis10@mail.ru
Muyzhnek, Ekaterina L., candidate of biological science, science director of company “MiraxBioPharma”.
115054, Russia, Moscow, Valovaya str. 21/125. Tel.: +74957658787. E-mail: muyzhnekEL@ilmixgroup.ru
Ashrafyan, Lev A., MD, academician of the Russian Academy of Sciences, director of Institute of Gynecoloigy and Mammology of Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74955314444. E-mail: LevAA@yahoo.com
Sukhikh, Gennady T., MD, academician of the Russian Academy of Sciences, director of Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74955314444. E-mail: secretariat@oparina4.ru
For citation: Kiselev V.I., Muyzhnek E.L., Ashrafyan L.A., Sukhikh G.T. A new paradigm in cervical neoplasia progression: from fundamental knowledge to practical gynecology. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (1): 5-12. (in Russian)
http: // dx.doi.org/10.18565/aig.2019.1.5-12