A new TNM classification of malignant tumors of the ovary, fallopian tube, and peritoneum
The changes in the 8th edition of the TNM classification of malignant tumors of the ovary, fallopian tube, and peritoneum, by examining the 2013 FIGO classification were reviewed; a rationale for these changes was provided.Pavlov K.A., Dubova E.A., Arkhipova V.I., Shmakov R.G., Pirogova M.M., Lishchuk S.V.
The paper presents the new 8th edition of the TNM classification of malignant tumors of the ovary, fallopian tube, and peritoneum, which is based on the 2013 FIGO classification. It describes in detail the key differences between the new classification and the previous one, as well as the features of using the new classification in clinical practice. In addition, there is concise information on the epidemiology of ovarian tumors, as well as modern views on their etiology.
The main innovations of this classification are as follows: its inclusion of tumors of the fallopian tube and peritoneum; the importance of identifying the histological type of a tumor and the degree of its differentiation; assignment of isolated lesions of the retroperitoneal lymph nodes to stage IIIA; differentiation of tumor extension from the peritoneum into the hepatic or splenic parenchyma (stage IIIC) and that of isolated metastases in the parenchyma of these organs (stage IVB).
Keywords
TNM
FIGO
tumor
ovary
fallopian tube
peritoneum
References
1. World Cancer Report 2014 // Eds B.W. Stewart, C. P. Wild – WHO Press: Lyon, 2014.
2. Prat J. Ovarian, fallopian tube and peritoneal cancer staging: Rationale and explanation of new FIGO staging 2013. Best. Pract. Res. Clin. Obstet. Gynaecol. 2015; 29(6): 858-869. doi: 10.1016/j.bpobgyn.
3. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer. 2010; 127(12): 2893-2917. doi: 10.1002/ijc.25516.
4. Kurman R.J., Carcangiu M.L., Herrington C.S., et al., editors. WHO classification of tumours of female reproductive organs. 4th ed. Lyon: IARC; 2014 [Chapter 1]: Tumours of the ovary.
5. Gilks C.B., Prat J. Ovarian carcinoma pathology and genetics: recent advances. Hum. Pathol. 2009; 40(9): 1213-1223. doi: 10.1016/j.humpath.
6. Prat J. Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features. Virchows Arch. 2012; 460(3): 237-249. doi: 10.1007/s00428-012-1203-5.
7. International Union Against Cancer (UICC). TNM classification of malignant tumours // Eds J.D. Brierley et al. –8th ed. – New York: Wiley-Blackwell, 2017.
8. Kandukuri S.R., Rao J. FIGO 2013 staging system for ovarian cancer: what is new in comparison to the 1988 staging system? Curr. Opin. Obstet. Gynecol. 2015; 27(1): 48-52. doi: 10.1097/GCO.0000000000000135.
9. Piek J.M., van Diest P.J., Zweemer R.P., Jansen J.W., Poort-Keesom R.J., Menko F.H. et al. Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. J. Pathol. 2001; 195(4): 451-456.
10. Crum C.P., Herfs M., Ning G., Bijron J.G., Howitt B.E., Jimenez C.A. et al. Through the glass darkly: intraepithelial neoplasia, top-down differentiation, and the road to ovarian cancer. J. Pathol. 2013; 231(4): 402-412. doi: 10.1002/path.4263.
11. Bakkum-Gamez J.N., Richardson D.L., Seamon L.G., Aletti G.D., Powless C.A., Keeney G.L. et al. Influence of intraoperative capsule rupture on outcomes in stage I epithelial ovarian cancer. Obstet. Gynecol. 2009; 113(1): 11-17. doi: 10.1097/AOG.0b013e3181917a0c.
12. Heintz A.P., Odicino F., Maisonneuve P., Quinn M.A., Benedet J.L., Creasman W.T. et al. Carcinoma of the ovary. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int. J. Gynaecol. Obstet. 2006; 95 Suppl 1: S161-S192.
13. Euscher E.D., Silva E.G., Deavers M.T., Elishaev E., Gershenson D.M., Malpica A. Serous carcinoma of the ovary, fallopian tube, or peritoneum presenting as lymphadenopathy. Am. J. Surg. Pathol. 2004; 28:1217-1223.
14. Bakkar R., Gershenson D., Fox P., Vu K., Zenali M., Silva E. Stage IIIC ovarian/peritoneal serous carcinoma: a heterogeneous group of patients with different prognoses. Int. J. Gynecol. Pathol. 2014; 33: 302-308.
15. Prat J. FIGO Committee on Gynecologic Oncology. Staging classification for cancer of the ovary, fallopian tube, and peritoneum. Int. J. Gynecol. Obstet. 2014; 124: 1 -5.
Received 13.10.2017
Accepted 27.10.2017
About the Authors
Pavlov Konstantin, PhD, pathologist, department of pathology A.I. Buranazyan Federal medical and biological Center of the Federal medical and biological Agency of Russian Federation. 123098, Russia, Moscow, Marshala Novikova str. 23. Tel.: +79104423438. E-mail: pavlovkos@gmail.comDubova Elena, MD, PhD, researcher, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia; pathologist, department of pathology A.I. Buranazyan Federal medical and biological Center of the Federal medical and biological Agency of Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79169323778. E-mail: dubovaea@gmail.com. www.orcid.org/0000-0003-0514-3804
Arkhipova Valeriya, PhD, head of gynecological department A.I. Buranazyan Federal medical and biological Center of the Federal medical and biological Agency of Russian Federation. 123098, Russia, Moscow, Marshala Novikova str. 23. Tel.: +74951908512. E-mail: varxipova@fmbcfmba.ru
Shmakov Roman, MD, PhD, head physician, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74955314444. E-mail: mdshmakov@gmail.com. www.orcid.org/0000-0002-2206-1002
Pirogova Mariya, postgraduate, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79160944569. E-mail: pirogovamariya@gmail.com
Sergey Lishchuk, head of department of pathology, A.I. Buranazyan Federal medical and biological Center of the Federal medical and biological Agency of Russian Federation. 123098, Russia, Moscow, Marshala Novikova str. 23. Tel.: +74951909490. E-mail: slishuk@fmbcfmba.ru
For citations: Pavlov K.A., Dubova E.A., Arkhipova V.I., Shmakov R.G., Pirogova M.M., Lishchuk S.V. A new TNM classification of malignant tumors of the ovary, fallopian tube, and peritoneum. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (7): 114-9. (in Russian)
https://dx.doi.org/10.18565/aig.2018.7.114-119
Similar Articles
