MicroRNAs and premature ovarian insufficiency

Dmitrieva M.L., Tikhonovskaya O.A., Romanova A.A., Logvinov S.V.

Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia
The relevance of studying the role of microRNAs in the pathogenesis of diseases of organs and systems is beyond question. The reproductive system is no exception. Since the early 2000s, many studies have been conducted to identify microRNAs in the ovaries. A literature review demonstrates the important role of microRNAs in folliculogenesis, including as regulators of apoptosis of granulosa cells, ovulation, and luteinization. It is established that microRNAs can be important regulatory molecules directly involved in premature ovarian insufficiency and polycystic ovary syndrome. MicroRNAs can become biological markers of ovarian reserve, which is of great importance in reproductology.


ovarian insufficiency


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Received 04.06.2019

Accepted 21.06.2019

About the Authors

Margarita L. Dmitrieva, PhD, Assistant of the Department of Obstetrics and Gynecology Siberian State Medical University.
Phone: +7 (913) 845-04-75. E-mail: margarita0708@yandex.ru
Address: 2 Moscowski Trakt Street Tomsk Russia 634050
Olga A. Tikhonovskaya, MD, Professor of the Department of Obstetrics and Gynecology Siberian State Medical University.
Phone: +7 (3822) 901-101 (1736). E-mail: tikhonovskaya2012@mail.ru
Address: 2 Moscowski Trakt Street Tomsk Russia 634050.
Anastasia А. Romanova, student of the 2nd course of the Faculty of Medicine.
E-mail: doch.aleksandraromanova@gmail.com
Address: 2 Moscowski Trakt Street Tomsk Russia 634050.
Sergey V. Logvinov, MD, Professor, Head of the Department of Histology, Embryology and Cytology Siberian State Medical University.
Phone: +7 (3822) 901-101 (1929). E-mail: s_logvinov@mail.ru
Address: 39 Uchebnaya Street Tomsk Russia 634034.

For citation: Dmitrieva M.L., Tikhonovskaya O.A., Romanova A.A., Logvinov S.V. MicroRNAs and premature ovarian insufficiency.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020;1: 40-6. (In Russian).

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