Use of dehydroepiandrosterone in a patient with infertility and androgen deficiency

Gavisova A.A., Shevtsova M.A., Tskhovrebova L.T., Mikhaylova N.D., Nikolaeva A.V.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Background. Diminished ovarian reserve is one of the causes of female infertility and a poor response in ovulation induction. Despite advances in clinical embryological approaches and molecular genetic technologies, there are difficulties achieving pregnancy and the birth of a baby with the genetic material from a woman herself with diminished ovarian reserve.
Case report. The paper describes a clinical case of the birth of a healthy baby in a patient with diminished ovarian reserve, infertility, and developing premature ovarian failure, who was prescribed dehydroepiandrosterone (DHEA) therapy.
Conclusion. The presented clinical case cannot fully demonstrate DHEA treatment success in women with a sharply diminished ovarian reserve. Such situations occur sporadically without DHEA. In the author’s opinion, long-term (9-month) use of DHEA and careful monitoring of the ovaries and hormones are necessary to control treatment efficiency.

Keywords

androgen deficiency
androgen therapy
infertility
folliculogenesis
dehydroepiandrosterone
dehydroepiandrosterone sulfate
androstenedione

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Received 30.06.2020

Accepted 10.10.2020

About the Authors

Alla A. Gavisova, Ph.D., Senior Researcher of the 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. E-mail: gavialla@yandex.ru.
117997, Russia, Moscow, Ac. Oparina str., 4.
Marina A. Shevtsova, clinical resident of the 2nd year of study, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. E-mail: marina_981995@mail.ru.
117997, Russia, Moscow, Ac. Oparina str., 4.
Linda T. Tskhovrebova, clinical resident of the 2nd year of study, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. E-mail: linda.tskhovrebova@mail.ru.
117997, Russia, Moscow, Ac. Oparina str., 4.
Nina D. Mikhaylova, graduate student of the 1st year of study, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. E-mail: mihailnina@mail.ru.
117997, Russia, Moscow, Ac. Oparina str., 4.
Anastasiya V. Nikolaeva, Ph.D., chief physician, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. E-mail: a_nikolaeva@oparina4.ru.
117997, Russia, Moscow, Ac. Oparina str., 4.

For citation: Gavisova A.A., Shevtsova M.A., Tskhovrebova L.T., Mikhaylova N.D., Nikolaeva A.V. Use of dehydroepiandrosterone in a patient with infertility and androgen deficiency.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 11: 237-242 (in Russian).
https://dx.doi.org/10.18565/aig.2020.11.237-342

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