Uterine sarcoma and pregnancy: modern view on the problem

Tskhay V.B., Pashov A.I., Ashrafyan L.A., Rachkovskaya V.V.

1) Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia; 2) Immanuel Kant Baltic Federal University, Kaliningrad, Russia; 3) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
The scientific review considers a gynecological disease, such as uterine sarcoma. The paper presents the main definitions of the gynecological disease, provides statistical data on the prevalence of this disease, describes its current classifications, and touches upon the etiological and pathogenetic aspects of uterine sarcoma. It reviews the current foreign and Russian sources of literature data on the incidence of uterine sarcoma during pregnancy and analyzes the outcomes of pregnancies. The authors also discuss the general principles of surgical treatment for this type of cancer, give an account of the possible volumes of surgical intervention, and highlight the expediency and principles of radiation therapy and adjuvant chemotherapy. They detail clinical outcomes and survival rates in women after surgical intervention of varying complexity and volume. Much attention is paid to the incidence of uterine sarcoma in women of childbearing age who are interested in maintaining their reproductive function in the future. The paper describes treatment options for uterine sarcoma (presents clinical cases), by preserving further female reproductive function, namely organ-sparing operations.
Conclusion: Organ-sparing operations in women of childbearing age with detected uterine sarcoma are an experimental procedure. However, the data on survival rates are more encouraging in patients with low- and moderate-grade endometrial stromal sarcoma (LMGESS) after organ-sparing surgery. From this it is inferred that organ-sparing surgery can be proposed and performed in women who are interested in maintaining their reproductive function.

Authors’ contributions: Tskhay V.B., Pashov A.I., Ashrafyan L.A. – concept and design of the investigation; Pashov A.I.,
Tskhay V.B., Rachkovskaya V.V. – material collection and processing; Rachkovskaya V.V. – statistical data processing;
Ashrafyan L.A., Pashov A.I., Tskhay V.B. – writing the text; Rachkovskaya V.V., Pashov A.I. – editing.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: There are no funding sources.
For citation: Tskhay V.B., Pashov A.I., Ashrafyan L.A., Rachkovskaya V.V.
Uterine sarcoma and pregnancy: modern view on the problem.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; 1: 13-19 (in Russian)


uterine sarcoma
corpus uteri cancer


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Received 04.10.2022

Accepted 01.12.2022

About the Authors

Vitaly B. Tskhay, Dr. Med. Sci., Professor, Head of the Department of Perinatology, Obstetrics and Gynecology of the Medical Faculty, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministyr of Health of Russia, +7(923)287-21-34, tchai@yandex.ru, 660022, Russia, Krasnoyarsk, P. Zheleznyak str., 1.
Alexander I. Pashov, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology of the Medical Institute, I. Kant Baltic Federal University,
+7(911)461-49-98, pachov@mail.ru, 236016, Russia, Kaliningrad, A. Nevsky str., 14.
Lev A. Ashrafyan, Academician of the RAS, Dr. Med. Sci., Professor, Deputy Director, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Director of the Institute of Oncogynecology and Mammology, +7(495)531-44-44, levaa2004@yahoo.com,
117997, Russia, Moscow, Akademika Oparina str., 4.
Valeria V. Rachkovskaya, postgraduate student of the Department of Obstetrics and Gynecology of the Medical Institute, I. Kant Baltic Federal University,
+7(952)117-48-18, losevavaleria2104@mail.ru, 236016, Russia, Kaliningrad, A. Nevsky str., 14.
Corresponding author: Valeria V. Rachkovskaya, losevavaleria2104@mail.ru

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