Noninvasive prenatal testing in Russia: a population study

Kudryavtseva E.V., Kanivets I.V., Kievskaya Yu.K., Baranov I.I., Kovalev V.V., Korostelev S.A.

1) Department of Obstetrics and Gynecology, Ural State Medical University, Ministry of Health of Russia, Yekaterinburg, Russia; 2) OOO “Genomed”, Moscow, Russia; 3) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; 4) I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
Objective. To evaluate the efficiency of DNA-based noninvasive prenatal test (NIPT) in identifying major aneuploidies in Russia.
Subjects and methods. The investigation enrolled 27,845 patients who had undergone NIPT in 2013–2018. The patients’ mean age was 34.2±3.63 years; the mean gestational age at which the women underwent NIPT was 15 weeks and 2 days’ gestation.
Results and discussion. Various NIPTs in Russia in 2013–2018 revealed a high risk of fetal chromosomal anomalies in 739 (2.6%) cases, 733 (99.18%) of them underwent invasive prenatal diagnosis, the presence of fetal chromosomal abnormalities was not confirmed in 12 (1.63%) cases. False negative results were 0.014%. The initial study could not yield a NIPT result in 1322 (4.7%) patients because of a low fetal fraction; however, the repeat study was effective in 80.1% of them.
Conclusion. NIPT is a more accurate study than standard combined prenatal screening and has high sensitivity and specificity for trisomies 13, 18, and 21.


noninvasive prenatal DNA test
prenatal diagnosis
Down syndrome
prenatal screening


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Received 01.11.2019

Accepted 29.11.2019

About the Authors

Elena V. Kudryavtseva, PhD, associate professor of the Department of Obstetrics and Gynecology FPK and PP and PF FSBEI HE UMMU. Tel .: +7(922)616-4012;
620109 Russia, Yekaterinburg, Repin, d. 3.
Ilya V. Kanivets, PhD, head of the department of genetics. LLC “Genomed”. Tel .: +7 (495)660-83-77; e-mail:; 115093 Russia, Moscow, Podolskoye Shosse, 8, building. 5.
Julia K. Kievskaya, geneticist of LLC Genomed. Tel.: +7 (495)660-83-77; e-mail:
115093, Russia, Moscow, Podolskoye Shosse, 8, bldg. 5.
Igor I. Baranov, MD, professor, head of the organizational and methodological department of FSBI NIMITs AGiP them. Kulakova, Moscow. Tel .: +7(495)438-94-92.
E-mail: Address: 117997, Russia, Moscow Academician Oparin, d. 4.
Vladislav V. Kovalev, MD, professor, head of the Department of Obstetrics and Gynecology, FPK and PP and PF FSBEI HE UMMU. Tel .: +7(919)360-0670;
e-mail: 620109, Russia, Yekaterinburg, Repin, 3.
Sergey A. Korostelev, MD, professor of the Department of Organization and Management in the Field of Drug Circulation, Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after THEM. Sechenov of the Ministry of Health of Russia. Phone: +7 (499) 609-14-00;
119991 Russia, Moscow, ul. Bolshaya Pirogovskaya, d. 2, p. 4.

For citation: Kudryavtseva E.V., Kanivets I.V., Kievskaya J.K., Baranov I.I., Kovalev V.V., Korostelev S.A. Non-invasive prenatal test in Russia: a population study.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 12:30-5. (In Russian).

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