Prenatal diagnosis of Siamese twins after in vitro fertilization with preimplantation genetic diagnosis
Background: Siamese or undivided twins are one of the most formidable complications of monozygotic twins. This pathology has an extremely poor prognosis and, as a rule. Pregnancy in this case results in premature termination.Marzoeva O.V., Yarygna T.A., Gasanova R.M., Sypchenko E.V., Leonova E.I.
Case report: The paper describes a case of the earliest prenatal diagnosis of Siamese twins in the Russian Federation. The case can be considered unique, as the pregnancy has occurred in a woman having a history of unsuccessful pregnancy with a fetus with multiple malformations. It has been considered that this pathology cannot practically occur after in vitro fertilization (IVF); however, the review of foreign and Russian literature says the opposite and the probable cause may be an injury of the pellucid zone of the blastocyst. The pregnancy described in the paper resulted from IVF with preimplantation genetic diagnosis. This method of genetic diagnosis allows one to select genetically healthy embryos with a normal number of chromosomes, but it is incapable of excluding this pathology. In the Perinatal Cardiology Center, the patient at 8 weeks and 2 days’ gestation was diagnosed with congenital anomalies in embryos. Short tandem repeat (STR) markers were analyzed using the quantitative fluorescence polymerase chain reaction (QF PCR) assay that did not reveal aneuploidies of chromosomes 7, 13, 15, 16, 18, 21, 22, Х, and Y.
Conclusion: The earliest diagnosis of this pathology is as relevant as possible, since it allows a reduction of both the risks of postoperative complications and the patient’s psychological trauma associated with unviable pregnancy termination, since it happens during the first trimester even before the onset of the fetal period.
Authors’ contributions: Marzoeva O.V., Yarygina T.A., Gasanova R.M., Sypchenko E.V. – concept and design of the investigation; Marzoeva O.V., Yarygina T.A. – writing the text; editing; Marzoeva O.V., Yarygina T.A., Sypchenko E.V., Leonova E.I. – material collection and processing.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has been conducted within the framework of the applied scientific topic АААА-А 20-120032390073-8.
Patient Consent for Publication. The patient has signed an informed consent form to publication of her data.
For citation: Marzoeva O.V., Yarygina T.A., Gasanova R.M., Sypchenko E.V., Leonova E.I. Prenatal diagnosis of Siamese twins after in vitro fertilization with preimplantation genetic diagnosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (6): 160-164 (in Russian)
https://dx.doi.org/10.18565/aig.2023.24
Keywords
Siamese twins
multiple pregnancy
prenatal diagnosis
in vitro fertilization
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Received 31.01.2023
Accepted 29.05.2023
About the Authors
Olga V. Marzoeva, PhD, Doctor of Ultrasound Diagnostics, Researcher at the Perinatal Cardiology Center, A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of Russia, +7(495)414-78-75, ovmarzoeva@bakulev.ru, https://orcid.org/0000-0003-4475-0105, 121552, Russia, Moscow, Rublevskoe shosse, 135.Tamara A. Yarygina, PhD, Specialist of Ultrasound Diagnostics, Researcher at the Perinatal Cardiology Center, A.N. Bakulev National Medical Research Center of Cardiovascular Surgery, Ministry of Health of Russia; Associated Professor at the Department of Ultrasound Diagnostics of the Faculty of Continuing Medical Education of
the Medical Institute, Patrice Lumumba Peoples’ Friendship University of Russia, +7(495)414-78-75, tamarayarygina@gmail.com, https://orcid.org/0000-0001-6140-1930,
121552, Russia, Moscow, Rublevskoe shosse, 135.
Rena M. Gasanova, Dr. Med. Sci., Head of the Perinatal Cardiology Center, A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of Russia, 121552, Russia, Moscow, Rublevskoe shosse, 135; Doctor of Ultrasound Diagnostics, Department of Ultrasound and Functional Diagnostics, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Academician Oparin str., 4, rmgasanova@bakulev.ru, https://orcid.org/0000-0003-3318-1074
Elena V. Sypchenko, PhD, Doctor of Ultrasound Diagnostics, Perinatal Cardiology Center, A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of Russia, +7(495)414-78-75, evsypchenko@bakulev.ru, https://orcid.org/0000-0002-8809-7913, 121552, Russia, Moscow, Rublevskoe shosse, 135.
Elena I. Leonova, Doctor of Ultrasound Diagnostics, Perinatal Cardiology Center, A.N. Bakulev National Medical Research Center for Cardiovascular Surgery Ministry of Health of Russia, +7(495)414-78-75, eileonova@bakulev.ru, https://orcid.org/0000-0002-6140-7950, 121552, Russia, Moscow, Rublevskoe shosse, 135.
Corresponding author: Olga V. Marzoeva, ovmarzoeva@bakulev.ru
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