Changes in placental weight-to-birth weight ratio in cases of fetal congenital heart disease

DOI

https://dx.doi.org/10.18565/aig.2025.132

Yarygina T.A., Gasanova R.M., Dziuba G.S., Makhukova N.A., Barinova I.V., Shchegolev A.I., Gus A.I., Shmakov R.G.
1) Academician V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia; 2) A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of Russia, Moscow, Russia; 3) Patrice Lumumba Peoples' Friendship University of Russia, Moscow Russia; 4) Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 5) M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia

Objective: Analysis of placental weight-to-birth weight ratio in healthy full-term newborns and in babies born with congenital heart disease.
Materials and methods: A comparative analysis of newborns’ weight, placental weight and placental weight-to-birth weight ratio was conducted between the main group, which comprised 100 observations with prenatally diagnosed fetal CHD and the control group, which included 100 healthy newborns.
Results: In the studied groups, there were no statistically significant differences in birth weight: 3412 (409) g (the 65th percentile) weighed newborns with CHD, and 3397 (429) g (the 64th percentile) weighed healthy newborns (p=0.8). Placental weight was significantly lower in the group with CHD, compared with the control group – 460 (98) g (the 42th percentile) versus 513 (104) g (the 57th percentile) (p=0.003). Placental weight-to-birth weight ratio was 0.14 (the 25th percentile) versus 0.15 (the 50th percentile) (p<0.001), as well as there was lower frequency of observations with placental weight-to-birth weight ratio less than the 10th percentile – 31% and 9% (p<0.001), respectively.
Conclusion: The observations showed that there was a disproportionate reduction in placental weight in relation to the newborn’s weight in the group with fetal CHD compared with the control group of healthy children, that may be a pathogenetic basis for a high incidence of post-hypoxic complications in this cohort of patients.

Authors' contributions: Yarygina T.A., Shmakov R.G. – the concept and design of the study; Yarygina T.A., Gasanova R.M., Dziuba G.S., Makhukova N.A. – text writing; Yarygina T.A., Dziuba G.S., Makhukova N.A., Barinova I.V. – material collection and processing; Gasanova R.M., Shchegolev A.I., Gus A.I., Shmakov R.G. – text editing.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted within the framework of applied scientific research topic No. 123020300017-1.
Ethical Approval: The study was approved by the local Ethics Committee of A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of Russia.
Patient Consent for Publication: The patients have signed informed consent for participation in the study and publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Yarygina T.A., Gasanova R.M., Dziuba G.S., Makhukova N.A., Barinova I.V., Shchegolev A.I.,
Gus A.I., Shmakov R.G. Changes in placental weight-to-birth weight ratio in cases of fetal congenital heart disease.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (7): 48-57 (in Russian)
https://dx.doi.org/10.18565/aig.2025.132

placenta

placental weight

placental weight-to-birth weight ratio

fetal hypoxia

congenital heart disease

fetal malformations

prenatal diagnosis

Full text (in Russian)

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Received 16.05.2025

Accepted 04.06.2025

Tamara A. Yarygina, PhD, Head of the Ultrasound Diagnostics Department, Academician V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, 101000, Russia, Moscow, Pokrovka str., 22a; Researcher at the Perinatal Cardiology Center, A.N. Bakulev National Medical Research Center of Cardiovascular Surgery, Ministry of Health of Russia, 121552, Russia, Moscow, Roublyevskoe Shosse, 135; Associated Professor at the Department of Ultrasound Diagnostics of the Faculty of Continuing Medical Education of the Medical Institute, Patrice Lumumba Peoples’ Friendship University of Russia, 127015, Russia, Moscow, Pistsovaya str., 10,
+7(495)414-78-75, tamarayarygina@gmail.com, https://orcid.org/0000-0001-6140-1930
Rena M. Gasanova, Dr. Med. Sci., Head of the Perinatal Cardiology Center, A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of Russia, 121552, Russia, Moscow, Roublyevskoe Shosse, 135; Physician of Ultrasound Diagnostics, Department of Ultrasound and Functional Diagnostics, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, rmgasanova@bakulev.ru, https://orcid.org/0000-0003-3318-1074
Galina S. Dziuba, Researcher at the Pathology Department, Academician V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, 101000, Russia, Moscow, Pokrovka str., 22a, Gala22_88@mail.ru, https://orcid.org/0009-0002-7459-4369
Natalya A. Makhukova, Junior Researcher at the Pathological Anatomy Department, Academician V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, 101000, Russia, Moscow, Pokrovka St., 22a, n.a.makhukova@mail.ru, https://orcid.org/0009-0007-9824-1804
Irina V. Barinova, Dr. Med. Sci., Head of the Pathoanatomical Department, Academician V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, 101000, Russia, Moscow, Pokrovka str., 22a, barinova.irina.vladimirovna@gmail.com, https://orcid.org/0000-0003-0447-1734
Alexander I. Shchegolev, Dr. Med. Sci., Professor, Head of the 2nd Pathoanatomical Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, +7(495)531-44-44, ashegolev@oparina4.ru,
https://orcid.org/0000-0002-2111-1530
Alexander I. Gus, Dr. Med. Sci., Professor, Chief Researcher at the Department of Ultrasound and Functional Diagnostics, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4; Head of the Department of Ultrasound Diagnostics of the Faculty of Continuing Medical Education of the Medical Institute, Patrice Lumumba Peoples’ Friendship University of Russia, 127015, Russia, Moscow, Pistsovaya str., 10, a_gus@oparina4.ru, https://orcid.org//0000-0003-1377-3128
Roman G. Shmakov, Dr. Med. Sci., Professor of the Russian Academy of Sciences, Director, Academician V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, 101000, Russia, Moscow, Pokrovka str., 22a; Head of the Department of Obstetrics and Gynecology, Faculty of Advanced Medical Studies, M.F. Vladimirsky Moscow Regional Research Clinical Institute, mdshmakov@mail.ru https://orcid.org/0000-0002-2206-1002
Corresponding author: Tamara A. Yarygina, tamarayarygina@gmail.com

Changes in placental weight-to-birth weight ratio in cases of fetal congenital heart disease

Yarygina T.A., Gasanova R.M., Dziuba G.S., Makhukova N.A., Barinova I.V., Shchegolev A.I., Gus A.I., Shmakov R.G.

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