About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
Logout
Obstetrics and Gynegology2023№12
Placental hemangioma

Placental hemangioma

DOI
https://dx.doi.org/10.18565/aig.2023.219

Frolova E.A., Tumanova U.N., Shchegolev A.I.

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

The article presents the analysis of the literature data on the role of placental hemangioma. Hemangioma refers to rare benign non-trophoblastic tumors of the placenta and it can have several synonyms. According to the literature, the diagnosis and risk of complications depend on the size of the tumor. The diagnosis is made prenatally on the basis of ultrasound imaging of a round-shaped hypoechoic formation with relatively clear boundaries of a homogeneous or heterogeneous structure located on the fetal surface of the placenta. The use of color Doppler ultrasonography makes it possible to visualize the feeding vessels included in this formation and peri-tumor diffuse vascularization. The variability of the histological structure and immunohistochemical characteristics of the tumor are noted. Complications include the development of uteroplacental insufficiency, polyhydramnios, preeclampsia, fetal distress, placental abruption, preterm birth, fetal death or artificial termination of pregnancy. Large and giant hemangiomas (more than 4–5 cm) may require medical interventions aimed at tumor devascularization.
Conclusion: Though placental hemangioma occurs rarely, it is characterized by an increased risk of complications and adverse outcomes for both the mother and the fetus.

Authors’ contributions: Frolova E.A. – search for publications, obtaining data for analysis, processing and analysis of the material on the topic, writing the text of the article; Tumanova U.N. – processing and analysis of the material on the topic, writing the text of the article; Shchegolev A.I. – search for publications, editing the text.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Frolova E.A., Tumanova U.N., Shchegolev A.I. Placental hemangioma.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (12): 32-38 (in Russian)
https://dx.doi.org/10.18565/aig.2023.219

Keywords

placenta
hemangioma
chorangioma
fetus
newborn
Full text (in Russian)

References

  1. Cheung A.N., Hui P., Shih I., eds. Gestational trophoblastic disease. Lokuhetty D., White V.A., Watanabe R. Female genital tumours. WHO Classification of Tumours, 5th Edition. Lyon: Internal Agency for Research on Cancer (IARC). 2020: 309-33.
  2. Fox H., Sebire N.J. Pathology of the placenta. Elsevier Health Sciences; 2007: 401-30.
  3. Vogel M., Turowski G., Horn L.C. Clinical Pathology of the placenta. Walter de Gruyter GmbH, Berlin/Boston; 2019. 470 p.
  4. Baergen R.N., Matrai C. Chorangiotic lesions, benign tumors, and heterotopias. In: Baergen R.N., Burton G.J., Kaplan C.G. eds. Benirschke's pathology of the human placenta. Springer Nature Switzerland AG; 2022: 821-36.https://dx.doi.org/10.1007/978-3-030-84725-8_30.
  5. Kraus F.T., Raymond W., Redline M.D., Gersell M.D., Michael D., Nelson Ph.D. et al. Placental pathology. American Registry of Pathology; 2004. 331 р.
  6. Benirschke K., Kaufmann P., Baergen R. Pathology of the human placenta. 5th ed. Springer New York; 2006: 863-76. https://dx.doi.org/10.1007/b 13792.
  7. Baergen R.N. Manual of pathology of the human placenta. Second ed. Springer Science+Business Media, LLC; 2011: 415-26. https://dx.doi.org/10.1007/978-1-4419-7494-5_22.
  8. Barry F.E., McCoy C.P., Callahan W.P. Hemangioma of the umbilical cord. Am. J. Obstet. Gynecol. 1951; 62(3): 675-80.
  9. Дан В.Н., Щеголев А.И., Сапелкин С.В. Современные классификации врожденных пороков развития сосудов (ангиодисплазий). Ангиология и сосудистая хирургия. 2006; 12(4): 28-33. [Dan V.N., Shchegolev A.I., Sapelkin S.V. Presentday classifications of congenital vascular malformations (angiodysplasias). Angiology and vascular surgery. 2006; 12(4): 28-33. (in Russian)].
  10. Redline R.W. Fetal stromal-vascular developmental abnormalities. In: Raymond W. Redline, ed., Theonia K., Roberts D.J. Placental and gestational pathology. University Press; 2018: 79-114. https://dx.doi.org/10.1017/9781316848616.
  11. Khong T.Y., Mooney E.E., Nikkels P.G.J., Morgan T.K., Gordijn S., eds. Pathology of the placenta: a practical guide. Springer Nature; 2019. 395 p.https://dx.doi.org/10.1007/978-3-319-97214-5.
  12. Международная классификация болезней – онкология (МКБ-О), 3 издание, 1 пересмотр. Сост. Фритц Э., Перси К., Джек Э., Шанмугаратнам К., Собин Л., Паркин Д.М. и др. Пер. с англ. Филочкиной А.В., под ред. Беляева А.М., Чепика О.Ф., Артемьевой А.С., Барчука А.А., Комарова Ю.И. СПб.: Издательство «Вопросы онкологии»; 2017. 352 с. [International classification of diseases for oncology (ICD-O), 3rd edition, 1st revision. Fritz A., Percy C., Jack A., Shanmugaratnam K., Sobin L., Parkin D.M. et al. Transl. from English Filochkina A.V., ed. Belyaeva A.M., Chepika O.F., Artemyeva A.S., Barchuka A.A., Komarova Yu.I. St. Petersburg: Publishing house “Oncology Issues”; 2017. 352 p. (in Russian)].
  13. Guschmann M., Henrich W., Entezami M., Dudenhausen J.W. Chorioangioma - new insights into a well-known problem. I. Results of a clinical and morphological study of 136 cases. J. Perinat. Med. 2003; 31(2): 163-9.https://dx.doi.org/10.1515/JPM.2003.022.
  14. Мальков П.Г., Гриневич В.Н., Морозова М.А., Зорина Ю.В., Юдина Е.В., Савченко Н.П. Гигантская плацентарная гемангиома (хорангиома). Архив патологии. 2009; 71(3): 37-9. [Malkov P.G., Grinevich V.N., Morozova M.A., Zorina Yu.V., Yudina E.V., Savchenko N.P. Giant placental hemangioma (chorangioma). Arhiv patologii. 2009; 71(3): 37-9. (in Russian)].
  15. Lim F.Y., Coleman A., Polzin W., Jaekle R., Habli M., Van Hook J. et al. Giant chorioangiomas: perinatal outcomes and techniques in fetoscopic devascularization. Fetal Diagn. Ther. 2015; 37(1): 18-23. https://dx.doi.org/10.1159/000363600.
  16. Reshetnikova O.S., Burton G.J., Milovanov A.P., Fokin E.I. Increased incidence of placental chorioangioma in high-altitude pregnancies: hypobaric hypoxia as a possible etiologic factor. Am. J. Obstet. Gynecol. 1996; 174(2): 557-61.https://dx.doi.org/10.1016/s0002-9378(96)70427-1.
  17. Froehlich L.A., Fujikura T. Significance of a single umbilical artery. Report from the collaborative study of cerebral palsy. Am. J. Obstet. Gynecol. 1966; 94(2):274-9. https://dx.doi.org/10.1016/0002-9378(66)90476-5.
  18. Ibraimov B., Ibraimova K., Nurmanova A. Chorioangioma and pregnancy. Journal of Clinical Medicine of Kazakhstan. 2017; 3 (45 suppl. 3): 73-6.https://dx.doi.org/10.23950/1812-2892-JCMK-00493.
  19. Germano Сh., Pilloni E., Rolfo A., Botta G, Parpinel G., Cortese P. еt al. Consecutive chorioangiomas in one pregnancy: clinical case and literature review. Health Science Reports. 2022; 5(13): 556. https://dx.doi.org/10.1002/hsr2.566.
  20. Buca D., Khalil A., Rizzo G., Sirotkina M., Makatsariya A., Liberati M. et al. Perinatal outcome of pregnancies complicated by placental chorioangioma: systematic review and meta-analysis. Ultrasound Obstet. Gynecol. 2020; 55(4): 441-9. https://dx.doi.org/10.1002/uog.20304.
  21. Shchegolev A.I., Tumanova U.N., Lyapin V.M., Kozlova A.V., Bychenko V.G., Sukhikh G.T. Complex method of CT and morphological examination of placental angioarchitechtonics. Bull. Exp. Biol. Med. 2020; 163(3): 405-11. https://dx.doi.org/10.1007/s10517-020-04897-4.
  22. Kataria N., Singh A., Bedi P.K. Giant placental chorangioma: a rare case report. J. Clin. Diagn. Res. 2016; 10(4): ED03-4. https://dx.doi.org/10.7860/JCDR/2016/17222.7540.
  23. Rech F., Salernitano D., Patella A. Il corionangioma placentare [Placental chorioangioma]. Minerva Ginecol. 2002; 54(5): 417-33.
  24. Sun X., Zhao H., Hao J., Lu L., Gu Y. Clinicopathological characteristics of placental chorioangioma: A clinicopathological study of 77 cases. Ann. Diagn. Pathol. 2022; 57: 151873. https://dx.doi.org/10.1016/j.anndiagpath.2021.151873.
  25. Липатов И.С., Тезиков Ю.В., Белоконева Т.С., Тезикова Т.А., Каганова М.А., Азаматов А.Р. Гестационные и перинатальные исходы при гигантской хориоангиоме. Российский вестник акушера-гинеколога. 2019; 19(4): 72-6. [Lipatov I.S., Tezikov Yu.V., Belokoneva T.S., Tezikova T.A., Kaganova M.A., Azamatov A.R., Gor'kova A.V. Gestational and perinatal outcomes in a giant chorioangioma. Russian Bulletin of obstetrician-gynecologist. 2019; 19(4): 72-6. (in Russian)].
  26. Massa G.D., Stabile G. CD133 expression in the chorioangioma of the placenta, manifested as a giant asymptomatic mass. Medicina (Kaunas). 2021; 57(2): 162. https://dx.doi.org/10.3390/medicina57020162.
  27. Кондриков Н.И., Баринова И.В. Патология матки. Руководство для врачей. М.: Практическая медицина; 2019. 352с. [Kondrikov N.I., Barinova I.V. Pathology of the uterus. Guide for doctors. Moscow: Practical Medicine; 2019. 352 p. (in Russian)].
  28. Guschmann M., Henrich W., Dudenhausen J.W. Chorioangiomas - new insights into a well-known problem II. An immuno-histochemical investigation of 136 cases. J. Perinat. Med. 2003; 31(2): 170-5. https://dx.doi.org/10.1515/JPM.2003.023.
  29. Павлов К.А., Дубова Е.А., Щеголев А.И. Фетоплацентарный ангиогенез при нормальной беременности: роль плацентарного фактора роста и ангиопоэтинов. Акушерство и гинекология. 2010; 6: 10-5. [Pavlov K.A., Dubova Ye.A., Shchegolev A.I. Fetoplacental angiogenesis during normal pregnancy: a role of placental growth factor and angiopoietins. Obstetrics and Gynecology. 2010; (6): 10-5. (in Russian)].
  30. Shchyogolev A.I., Dubova E.A., Pavlov K.A., Lyapin V.M., Kulikova G.V., Shmakov R.G. Morphometric characteristics of terminal villi of the placenta in pre-eclampsia. Bull. Exp. Biol. Med. 2012; 154(1): 92-5.https://dx.doi.org/10.1007/s10517-012-1883-5.
  31. Dubova E.A., Pavlov K.A., Lyapin V.M., Shchyogolev A.I., Sukhikh G.T. Vascular endothelial growth factor and its receptors in the placental villi of pregnant patients with pre-eclampsia. Bull. Exp. Biol. Med. 2013; 154(6): 792-5.https://dx.doi.org/10.1007/S10517-013-2058-8.
  32. Schulz-Hetzel I. Über das chorioangiom. Arch. Gynakol. 1978; 225(2): 131-46. https://dx.doi.org/10.1007/BF00670849.
  33. De la Ossa M.M., Cabello-Inchausti B., Robinson M.J. Placental chorangiosis. Arch. Pathol. Lab. Med. 2001; 125(9): 1258. https://dx.doi.org/10.5858/2001-125-1258-PC.
  34. Trask C., Lage J.M., Roberts D.J. A second case of 'chorangiocarcinoma' presenting in a term asymptomatic twin pregnancy: Choriocarcinoma in situ with associated villous proliferation. Int. J. Gynecol. Pathol. 1994; 13(1): 87-91. https://dx.doi.org/10.1097/00004347-199401000-00011.
  35. Faes T., Pecceu A., Van Calenbergh S., Moerman P. Chorangiocarcinoma of the placenta: a case report and clinical review. Placenta. 2012; 33(8): 658-61. https://dx.doi.org/10.1016/j.placenta.2012.04.012.
  36. Zanardini C., Papageorghiou A., Bhide A., Thilaganathan B. Giant placental chorioangioma: Natural history and pregnancy outcome. Ultrasound. Obstet. Gynecol. 2010; 35(3): 332-6. https://dx.doi.org/10.1002/uog.7451.
  37. Kinoshita Y., Inoue M., Sekiguchi K., Maeda T., Ihara K. Feto-maternal hemorrhage with placental chorioangioma: Two case reports. Pediatr. Int. 2022; 64(1): 15196. https://dx.doi.org/10.1111/ped.15196.
  38. Казачков Е.Л., Воропаева Е.Е., Семенов Ю.А., Пастернак А.Е. Гигантская хорангиома плаценты. Архив патологии. 2013; 5: 52-4. [Kazachkov E.L., Voropaeva E.E., Kazachkova E.A., Semenov Y.A., Pasternak A.E. Giant chorangioma of the placenta. Arhiv patologii. 2013; 5: 52-4.(in Russian)].
  39. Ma H., Liu Z., Ruan J. Placental chorioangioma and pregnancy outcome: a ten-year retrospective study in a tertiary referral centre. BMC Pregnancy Childbirth. 2023; 23(1): 381. https://dx.doi.org/10.1186/s12884-023-05719-x.
  40. Iacovella C., Chandrasekaran N., Khalil A., Bhide A., Papageorghiou A., Thilaganathan B. Fetal and placental vascular tumors: persistent fetal hyperdynamic status predisposes to poorer long-term neurodevelopmental outcome. Ultrasound Obstet. Gynecol 2014; 43(6): 658-61. https://dx.doi.org/10.1002/uog.13272.
  41. Dong T., Sher D., Luo Q. Pregnancy complications and adverse outcomes in placental chorioangioma: a retrospective cohort analysis. J. Matern. Fetal. Neonatal Med. 2020; 33(13): 2269-73. https://dx.doi.org/10.1080/14767058.2018.1548598.
  42. Nikolopoulos M., Otigbah C., Kalidindi M. Chorioangiomas in pregnancy - case report. J. Obstet. Gynaecol. 2019; 39(7): 1015-6. https://dx.doi.org/10.1080/01443615.2019.1576602.
  43. Wu Z., Hu W. Clinical analysis of 26 patients with histologically proven placental chorioangiomas. Eur. J. Obstet. Gynecol. Reprod. Biol. 2016; 199: 156-63. https://dx.doi.org/10.1016/j.ejogrb.2015.12.009.
  44. Щеголев А.И., Серов В.Н. Клиническая значимость поражений плаценты. Акушерство и гинекология. 2019; 3: 54-62. [Shchegolev A.I., Serov V.N. Clinical significance of placental lesions. Obstetrics and Gynecology. 2019; (3): 54-62. (in Russian)]. https://dx.doi.org/10.18565/aig.2019.3.54-62.
  45. Arora S., Khera N., Kaul A. Three-dimensional color Doppler acquisition of a highly vascular giant placental chorioangioma. Am. J. Obstet. Gynecol. 2022; 226(2): 259-60. https://dx.doi.org/10.1016/j.ajog.2021.08.021.
  46. Kesrouani A.K., Safi J., El Hajj M.A. Rapid evolution of placental chorioangioma: natural progression and outcome. J. Ultrasound. Med. 2013; 32(3): 545-7. https://dx.doi.org/10.7863/jum.2013.32.3.545.
  47. Eom H.M., Kim Y.N., Choi B.H., Jeong E.J., Byun J.M., Jeong D.H. et al. Chorioamniotic membrane separation caused by the seromucinous collection from a placental chorioangioma. Obstet. Gynecol. Sci. 2016; 59(3): 233-7. https://dx.doi.org/10.5468/ogs.2016.59.3.233.
  48. Kim A., Economidis M.A., Stohl H.E. Placental abruption after amnioreduction for polyhydramnios caused by chorioangioma. BMJ Case Rep. 2018; 2018: bcr2017222399. https://dx.doi.org/10.1136/bcr-2017-222399.
  49. Shrivastava M., Firdous. F., Murty Ch.V.R., Jaweria. Chorangioma - A rare case report. Scholars J. Med. Case Rep. 2017; 5(9): 517-20. https://dx.doi.org/10.36347/sjmcr.2017.v05i09.001.
  50. Sepulveda W., Wong AE., Herrera L., Dezerega V., Devoto J.C. Endoscopic laser coagulation of feeding vessels in large placental chorioangiomas: report of three cases and review of invasive treatment options. Prenat. Diagn. 2009; 29(3):201-6. https://dx.doi.org/10.1002/pd.2197.
  51. Hosseinzadeh P., Shamshirsaz A., Javadian P., Espinoza J., Gandhi M.,Ruano R. et al. Prenatal therapy of large placental chorioangiomas: case report and review of the literature. Am. J. Perinatol Rep. 2015; 5(2): 196-202.https://dx.doi.org/10.1055/s-0035-1558829.
  52. Papaioannou G.K., Evangelinakis N., Kourtis P., Konstantinidou A., Papantoniou N. Giant chorioangioma treated with interstitial laser coagulation. Ultrasound Obstet. Gynecol. 2018; 2(2): 280-1. https://dx.doi.org/10.1002/uog.18941.
  53. Emery S.P., D’Orons Ph., Bonadio J.F. Successful management of giant placental chorangioma by microcoil embolization. AJP Rep. 2018; 8(4): 230-3.https://dx.doi.org/10.1055/s-0038-1669944.

Received 11.09.2023

Accepted 10.11.2023

About the Authors

Ekaterina A. Frolova, pathologist of the 2nd Pathology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, https://orcid.org/0000-0003-2976-7128, 117997, Russia, Moscow, Ac. Oparina str., 4.
Uliana N. Tumanova, Dr. Med. Sci., Leading Researcher at the 2nd Pathology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, u.n.tumanova@yandex.ru, https://orcid.org/0000-0002-0924-6555, 117997, Russia, Moscow, Ac. Oparina str., 4.
Alexander I. Shchegolev, Dr. Med. Sci., Professor, Head of the 2nd Pathology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, ashegolev@oparina4.ru, https://orcid.org/0000-0002-2111-1530, 117997, Russia, Moscow, Ac. Oparina str., 4.

Similar Articles

№6 / 2023
Marianian A.Yu., Anisimova A.O., Kalkova A.N., Rashidova M.A., Rychkova L.V., Muradyan A.E.
Long-term consequences of the effect of alcohol on the fetus
№2 / 2024
Gasanbekova A.P., Frankevich N.A., Chagovets V.V., Tokareva A.O., Kachikowski Yu.N., Novoselova A.V., Karapetyan T.E.
The role of polyamines in noninvasive diagnosis of placenta-associated pregnancy complications
№8 / 2023
Shchegolev A.I., Tumanova U.N. Serov V.N.
The role of the placenta in the development of neonatal brain lesions
№9 / 2023
Nikitina I.V., Krogh-Jensen O.A., Budina A.Yu., Gordeev A.B., Zubkov V.V., Degtyarev D.N., Priputnevich T.V., Lenyushkina A.A.
Group B Streptococcus infection in pregnant women and newborns: clinical case and current state of the problem
№10 / 2021
Datsenko N.S., Volchek A.V., Yakimova A.V., Pozdnyakov I.M., Ageeva T.A., Marinkin I.O., Aidagulova S.V.
Placental insufficiency in pregnant women with high body mass index and without gestational diabetes
By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.