Management of pregnancy with placental mesenchymal dysplasia
Frolova N.I., Belokrinitskaya T.E., Batoyeva V.V., Garyashina E.A., Zolotukhina A.O., Makarova M.I.
Relevance: Placental mesenchymal dysplasia (PMD) is a rare morphological anomaly that can resemble a partial hydatidiform mole caused by the mosaicism of genes inherited from the father or both parents. PMD is rather often associated with severe complications in the fetus and/or mother. It is difficult to diagnose this condition and manage pregnancy due to the variety of clinical and laboratory manifestations of PMD.
Case report: This is a clinical observation of a case with of PMD which was misdiagnosed and treated as partial hydatidiform mole due to the similarity of their clinical and ultrasound signs. The clinical case had a favorable outcome: on the one hand, the erroneous diagnosis of partial hydatidiform mole did not result in termination of pregnancy, and on the other hand, PMD, fortunately, did not have severe antenatal and postnatal disorders in the offspring.
Conclusion: In order to identify the tactics of pregnancy management, the specialists of prenatal diagnostics should be cautious and carry out thorough antenatal differential diagnosis of partial hydatidiform mole and PMD. To stratify the risks to the mother and fetus, it is necessary to apply a multidisciplinary approach to the detailed comparison of ultrasound images, clinical and laboratory data during the whole pregnancy in each case of suspected partial hydatidiform mole on ultrasound examination.
Authors’ contributions: Belokrinitskaya T.E. – developing the concept and design of the study, general guidance, text editing; Frolova N.I. – collection and analysis of publications on the topic of the article; Batoyeva V.V., Garyashina E.A. – collecting and processing the clinical material; Zolotukhina A.O., Makarova M.I. – pathomorphological studies, preparation of macro- and microphotos of placenta, their description; Belokrinitskaya T.E., Frolova N.I. – writing the text of the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was reviewed and approved by the Research Ethics Committee of the Chita State Medical Academy, Ministry of Health of Russia.
Patient Consent for Publication: The patient provided an informed consent for the publication of her data.
For citation: Frolova N.I., Belokrinitskaya T.E., Batoyeva V.V., Garyashina E.A., Zolotukhina A.O., Makarova M.I. Management of pregnancy
with placental mesenchymal dysplasia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (12): 198-204 (in Russian)
https://dx.doi.org/10.18565/aig.2023.198
Keywords
mesenchymal dysplasia
placenta
alpha-fetoprotein
human chorionic gonadotropin
clinical and ultrasound signs
morphology
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Received 17.08.2023
Accepted 07.11.2023
About the Authors
Nataly I. Frolova, Dr. Med. Sci., Associate Professor of the Department of Obstetrics and Gynecology of the Pediatric Faculty and Faculty of Professional Retraining,Chita State Medical Academy, Ministry of Health of Russia, taasyaa@mail.ru, https://orcid.org/0000-0002-7433-6012, 672000, Russia, Chita, Gorky str., 39a.
Tatiana E. Belokrinitskaya, Dr. Med. Sci., Professor, Head of the Obstetrics and Gynecology Department of the Pediatric Faculty and Faculty of Professional Retraining,
Chita State Medical Academy, Ministry of Health of Russia, +7(3022)32-30-58, tanbell24@mail.ru, https://orcid.org/0000-0002-5447-4223,
672000, Russia, Chita, Gorky str., 39a.
Victoriya V. Batoyeva, obstetrician-gynaecologist of the Polyclinic Department, Transbaikal Regional Perinatal Centre, vikabatoeva04011968@gmail.com,
https://orcid.org/0009-0007-1880-0646, 672090, Russia, Chita, Kohansky str., 16.
Elena A. Garyashina, Head of the Polyclinic Department, Transbaikal Regional Perinatal Centre, sher.len@mail.ru, https://orcid.org/0009-0004-7412-4943,
672090, Russia, Chita, Kohansky str., 16.
Anastasiya O. Zolotukhina, Head of the Department of Pediatric and Prenatal Pathology, Transbaikal Regional Pathology Bureau, zolot-anastasiya@mail.ru,
https://orcid.org/0000-0002-1136-1798, 672038, Russia, Chita, Matveev str., 64.
Miroslava I. Makarova, pathologist of the Department of Pediatric and Prenatal Pathology, Transbaikal Regional Pathology Bureau, miroslava_kisele@mail.ru,
https://orcid.org/0000-0001-5235-9603, 672038, Russia, Chita, Matveev str., 64.
Corresponding author: Tatiana E. Belokrinitskaya, tanbell24@mail.ru
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