The role of the placenta in the development of neonatal brain lesions

Shchegolev A.I., Tumanova U.N. Serov V.N.

Academician V.I. Kulakov Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
The literature on the role of placental pathology in the development of lesions in the neonatal and fetal brain is analyzed. Structural damages and placental dysfunctions can be a cause of fetal developmental disorders and neonatal diseases. The literature data indicate that implantation disorders (as preeclampsia), circulatory disorders in the maternal (accelerated placental villous maturation and infarctions, and premature placental detachment) and in the and fetal (thrombotic vasculopathy) body, infectious, inflammatory, and immune processes (acute chorioamnionitis, chronic villitis, and funisitis), as well as massive perivillous fibrin, placenta increata, as well as umbilical cord abnormalities can lead to neurological disorders and brain damage in the newborn. The aggravating factor is the multiplicity and concurrence of different types of placental disorders. The most common brain lesions are considered to be the development of ischemic injuries, intraventricular hemorrhages, periventricular leukomalacia, and cerebral palsy. The important point of a number of placental disorders is the risk of their recurrence in subsequent pregnancies.
Conclusion: Despite the fact that morphological examination of the placenta is carried out only after childbirth, the results obtained during the examination are necessary for obstetricians and neonatologists to fully diagnose diseases of the newborn, as well as to determine treatment policy for brain lesions, in particular.

Authors' contributions: Shchegolev A.I. – processing and analysis of the material on the topic, writing the text of the manuscript; Tumanova U.N. – processing and analysis of the material on the topic, writing the text of the manuscript; Serov V.N. – analysis of the material on the topic, editing the text.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
For citation: Shchegolev A.I., Tumanova U.N., Serov V.N.
The role of the placenta in the development of neonatal brain lesions.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (8): 38-47 (in Russian)


newborn infant


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Received 08.08.2023

Accepted 23.08.2023

About the Authors

Alexander I. Shchegolev, Dr. Med. Sci., Professor, Head of the 2nd Department of Anatomic Pathology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,,, 117997, Russia, Moscow, Oparina str., 4.
Uliana N. Tumanova, Dr. Med. Sci., Leading Researcher at the 2nd Department of Anatomic Pathology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,,,
117997, Russia, Moscow, Oparina str., 4.
Vladimir N. Serov, Academician of the Russian Academy of Sciences, Dr. Med. Sci., Professor, President of the Russian Society of Obstetricians and Gynaecologists;
Chief Researcher, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Oparina str., 4.

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