Current possibilities of transcriptomics in the study of preeclampsia

Sidorova I.S., Nikitina N.A., Ageev M.B., Timofeev S.A., Morozova E.A.

Obstetrics and Gynecology Department No. 1, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia
The paper deals with modern transcriptomics technologies in the study and solution of a significant obstetric problem, such as preeclampsia. Transcriptomics is currently one of the most rapidly developing areas of systems biology, bioinformatics, and medicine, which make it possible to get information about the functional activity of the genome, by analyzing all transcripts synthesized by one cell or a group of cells. The paper presents a literature review of recently published studies of placental transcriptome that is of great importance in expanding knowledge about the normal development and functioning of the placenta allows one to take into account the possible effect of fetal sex on the expression profile of a gene and is an indispensable tool for studying the basic pathophysiological mechanisms of placental disorders. Genome-wide blood transcriptome analysis in pregnant women has shown multiple maternal gene expression pattern changes that are associated with preeclampsia just at the preclinical stage of its development, which will be able to identify the most accurate prognostic markers. The paper also highlights the issues of the intrauterine origin of diseases. It presents studies that have demonstrated the associations between genetic variants, changes in the placental transcriptome, and a risk for postnatal diseases.
Conclusion: The paper indicates prospects for the integrated use of “omics” technologies in the study of causal mechanisms for the development of placental syndromes and in the prediction of pregnancy complications and offspring health.


RNA sequencing


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Received 28.03.2022

Accepted 14.06.2022

About the Authors

Iraida S. Sidorova, Dr. Med. Sci., Professor, Academician of the RAS, Honoured Scientist of the Russian Federation, Department of Obstetrics and Gynaecology No. 1,
N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia,,
119991, Russia, Moscow, Trubetskaya str., 8, bld. 2.
Natalya A. Nikitina, Dr. Med. Sci., Professor, Department of Obstetrics and Gynaecology No. 1, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow
State Medical University, Ministry of Health of Russia,, 119991, Russia, Moscow, Trubetskaya str., 8, bld. 2.
Mikhail B. Ageev, PhD, Assistant at the Department of Obstetrics and Gynecology No. 1, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow
State Medical University, Ministry of Health of Russia,, 119991, Russia, Moscow, Trubetskaya str., 8, bld. 2.
Sergey A. Timofeev, Assistant at the Department of Obstetrics and Gynecology No. 1, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow
State Medical University, Ministry of Health of Russia,, 119991, Russia, Moscow, Trubetskaya str., 8, bld. 2.
Ekaterina A. Morozova, postgraduate student, Department of Obstetrics and Gynaecology No. 1, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia,, 119991, Russia, Moscow, Trubetskaya str., 8, bld. 2.

Authors' contributions: Sidorova I.S. – concept and design of the investigation, editing; Nikitina N.A., Ageev M.B., Morozova E.A. – material collection and processing; Nikitina N.A., Morozova E.A., Timofeev S.A. – writing the text.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has not been sponsored.
For citation: Sidorova I.S., Nikitina N.A., Ageev M.B., Timofeev S.A., Morozova E.A. Current possibilities of transcriptomics in the study of preeclampsia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 7: 5-12 (in Russian)

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