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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2025№6
Non-invasive detection of endometrial cancer:...

Non-invasive detection of endometrial cancer: focus on DNA methylation

DOI
https://dx.doi.org/10.18565/aig.2025.113

Bayramova G.R., Babich V.D., Andreev A.O., Zaretsky A.R.

1) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia; 3) N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Endometrial cancer (EC) is the most common malignancy of the female reproductive system and it remains a significant global healthcare challenge. Early detection of EC is known to be essential for optimizing therapeutic strategies and improving clinical prognosis. Given the limitations of traditional methods for diagnosing EC, researchers actively search for the possibility of developing and implementing new methods that can detect EC before its clinical manifestations. One of the most promising directions in this field involves identifying patterns of abnormal DNA methylation, which represents an early epigenetic event in endometrial carcinogenesis. This review examines molecular-genetic methods for diagnosing EC described in the literature, based on detecting abnormal gene methylation in various biological samples.
Conclusion: DNA methylation detection is a promising area in early diagnosis of EC from both scientific and practical perspectives, however, further research into this area is required.

Authors’ contributions: Bayramova G.R. – developing the concept and design of the study, editing and final approval of the article; Babich V.D. – search and analysis of literature, processing the source material, writing the text of the article; Andreev A.O. – search and analysis of literature, processing the source material, writing the text of the article; Zaretsky A.R. – developing the concept and design of the study, editing and final approval of the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Bayramova G.R., Babich V.D., Andreev A.O., Zaretsky A.R. 
Non-invasive detection of endometrial cancer: focus on DNA methylation.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (6): 44-50 (in Russian)
https://dx.doi.org/10.18565/aig.2025.113

Keywords

endometrial cancer
DNA methylation
molecular genetic markers
non-invasive detection
Full text (in Russian)

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Received 29.04.2025

Accepted 09.06.2025

About the Authors

Gyuldana R. Bayramova, Dr. Med. Sci., Honored Doctor of the Russian Federation, Professor at the Department of Obstetrics and Gynecology of the Institute of Professional Education, Head of the Department Obstetrician Gynecologist of the Research and Outpatient Department, Academician V.I. Kulakov National Medical Research Center
of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4; Professor at the Department of Obstetrics, Gynecology, Perinatology and Reproductology of the Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia,
119991, Russia, Moscow, Trubetskaya str., 8-2, +7(926)660-48-77, bayramova@mail.ru, https://orcid.org/0000-0003-4826-661X
Violetta D. Babich, PhD student, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4, +7(918)383-85-20, violettadmitrievna9@mail.ru, https://orcid.org/0009-0006-4101-0020
Alexander O. Andreev, obstetrician gynecologist at the Research and Outpatient Department, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4, +7(903)613-00-26, sasha.grash2010@yandex.ru, https://orcid.org/0000-0002-9835-440X
Andrew R. Zaretsky, Head of the Laboratory of Molecular Oncogenetics at the Institute of Translational Medicine, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4; Senior Researcher at the Molecular Technologies Department of the Research Institute of Translational Medicine, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia,
117997, Russia, Moscow, Ostrovityanova str., 1, +7(916)815-95-56, a-zaretsky@yandex.ru, https://orcid.org/0000-0002-7778-6617
Corresponding author: Gyuldana R. Bayramova, bayramova@mail.ru

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