Vitamin D deficiency in adult women

Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Malyavskaya S.I.

1) Institute of Pharmacoinformatics, Federal Research Center of Informatics and Management, Russian Academy of Sciences, Moscow, Russia; 2) Big Data Storage and Analysis Center, Moscow State University, Moscow, Russia; 3) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia; 4) Northern State Medical University, Ministry of Health of Russia, Arkhangelsk, Russia
The negative effects of vitamin D deficiency are much wider than only increased bone degradation. The paper gives the results of a systematic analysis of 1190 clinical and experimental studies of the effects of inadequate vitamin D supply during the menopausal transition and postmenopause. Vitamin D deficiency has been shown to contribute to the development of metabolic syndrome, breast tumors, muscle strength loss and sarcopenia, rheumatoid arthritis and lipid disturbances. Accordingly, adequate daily supplementation with vitamin D (2000-4000 IU/day) during the menopausal transition and subsequent postmenopause will compensate for vitamin D deficiency and contribute to the prevention of comorbidities.

Keywords

osteoporosis
perimenopause
postmenopause
vitamin D
detrimax

References

  1. Громова О.А., Торшин И.Ю., Лиманова О.А., Никонов А.А. Патофизиология вегетативно-сосудистых пароксизмов (приливы) у женщин в период менопаузы и механизм действия бета-аланина. Новая клинико-фармакологическая концепция. Гинекология. 2010; 12(2): 29-36. [Gromova O.A., Torshin I.Yu., Limanova O.A., Nikonov A.A. Pathophysiology of vegetative-vascular paroxysms (hot flushes) in women during menopause and the mechanism of action of beta-alanine. New clinical and pharmacological concept. Gynecology. 2010; 12 (2): 29-36. (in Russian)].
  2. Bueloni-Dias F.N., Orsatti C.L., Cangussu L.M., Poloni P.F., Spadoto-Dias D. et al. Isolated vitamin D supplementation improves the immune-inflammatory biomarkers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial. Menopause. 2018; 25(8): 897-903. https://dx.doi.org/10.1097/GME.0000000000001106.
  3. Гусев Е.И., Захарова И.Т., ред. Витамин D – смена парадигмы. М.: ГЭОТАР-Медиа; 2017. 568 с. [Gusev E.I., Zakharova I.T., ed. Vitamin D – a paradigm shift. Moscow: GEOTAR-Media; 2017. 568p. (in Russian)].
  4. Лесняк О.М., Никитинская О.А., Торопцова Н.В., Белая Ж.Е., Белова К.Ю., Бордакова Е.В., Гильманов А.Ж., Гуркина Е.Ю., Дорофейков В.В., Ершова О.Б., Зазерская И.Е., Зоткин Е.Г., Каронова Т.Л., Марченкова Л.А., Назарова А.В., Пигарова Е.А., Рожинская Л.Я., Сафонова Ю.А., Скрипникова И.А., Ширинян Л.В. и др. Профилактика, диагностика и лечение дефицита витамина D и кальция у взрослого населения России и пациентов с остеопорозом (по материалам подготовленных клинических рекомендаций). Научно-практическая ревматология. 2015; 53(4): 403-8. [Lesnyak O.M., Nikitinskaya O.A., Toroptsova N.V., Belaya Z.E., Belova K.Yu.,Bordakova E.V., Gilmanov A.Zh., Gurkina E.Yu., Dorofeykov V.V., Ershova OB, Zazerskaya I.E., Zotkin EG, Karonova T.L., Marchenkova L.A., Nazarova A.V., Pigarova E.A., Rozhinskaya L.Ya., Safonova Yu.A., Skripnikova I.A., Shirinyan L.V. et al. Prevention, diagnosis and treatment of vitamin D deficiency and calcium in the adult population of Russia and patients with osteoporosis (based on the prepared clinical guidelines). Scientific and practical rheumatology. 2015; 53 (4): 403-8. (in Russian)].
  5. Захаров И.С., Колпинский Г.И., Ушакова Г.А., Ушаков А.В., Ван В.Ч., Мигаль О.В., Архарова О.М. Распространенность остеопенического синдрома у женщин в постменопаузе. Медицина в Кузбассе. 2014; 13(3): 32-6. [Zakharov I.S., Kolpinsky G.I., Ushakova G.A., Ushakov A.V., Van V.Ch., Migal O.V., Arkharova O.M. The prevalence of osteopenic syndrome in postmenopausal women. Medicine in the Kuzbass. 2014; 13 (3): 32-6. (in Russian)].
  6. Mantovani A., Sani E., Fassio A., Colecchia A., Viapiana O., Gatti D. et al. Association between non-alcoholic fatty liver disease and bone turnover biomarkers in post-menopausal women with type 2 diabetes. Diabetes Metab. 2018; Oct 10. pii: S1262-3636(18)30195-2. https://dx.doi.org/10.1016/j.diabet.2018.10.001.
  7. Torshin I.Yu., Rudakov K.V. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: Metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2017; 27(2): 184-99. https://dx.doi.org/10.1134/S1054661817020110.
  8. Torshin I.Y., Rudakov K.V. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 1: Factorization approach. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2017; 27(1): 16-28. https://dx.doi.org/10.1134/S1054661817010151.
  9. Torshin I.Y., Rudakov K.V. On the theoretical basis of the metric analysis of poorly formalized problems of recognition and classification. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2015; 25(4): 577-87.
  10. Torshin I.Y., Rudakov K.V. On metric spaces arising during formalization of problems of recognition and classification. Part 1: Properties of compactness. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2016; 26(2): 274-84.
  11. Torshin I.Y., Rudakov K.V. On metric spaces arising during formalization of problems of recognition and classification. Part 2: density properties. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2016; 26(3): 483-96.
  12. Torshin I.Yu. Optimal dictionaries of the final information on the basis of the solvability criterion and their applications in bioinformatics. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2013; 23(2): 319-27.
  13. Громова О.А., Торшин И.Ю., Захарова И.Н., Спиричев В.Б., Лиманова О.А., Боровик Т.Э., Яцык Г.В. О дозировании витамина D у детей и подростков. Вопросы современной педиатрии. 2015; 14(1): 38-47. [Gromova O.A., Torshin I.Yu., Zakharova I.N., Spirichev V.B., Limanova O.A., Borovik T.E., Yatsyk G.V. About dosing of vitamin D in children and adolescents. Questions of modern pediatrics. 2015; 14 (1): 38-47.(in Russian)].
  14. Tian L., Yang R., Wei L., Liu J., Yang Y., Shao F. et al. Prevalence of osteoporosis and related lifestyle and metabolic factors of postmenopausal women and elderly men: A cross-sectional study in Gansu province Northwestern of China. Medicine (Baltimore). 2017; 96(43): e8294. https://dx.doi.org/10.1097/MD.0000000000008294.
  15. Hermann A.P., Brot C., Gram J., Kolthoff N., Mosekilde L. Premenopausal smoking and bone density in 2015 perimenopausal women. J. Bone Miner. Res. 2000; 15(4): 780-7. https://dx.doi.org/10.1359/jbmr.2000.15.4.780.
  16. Bentes C.M., Resende M., Miranda H., Netto C.C., Marinheiro L.P.F. Can Vitamin D supplementation alone effective to increase a physical fitness levels in post-menopausal women with metabolic disorders? Brief review. Diabetes Metab. Syndr. 2018; 12(1): 65-8. https://dx.doi.org/10.1016/j.dsx.2017.08.010.
  17. Park E.J., Lee H.S., Lee S.H., Shim K.W., Cho C., Yoo B.W. The level of vitamin D using the LC-MS/MS method and related factors in healthy Korean postmenopausal women. J. Obstet. Gynaecol. Res. 2018; 44(10): 1977-84. https://dx.doi.org/10.1111/jog.13745.
  18. Ho V., Danieli C., Abrahamowicz M., Belanger A.S., Brunetti V., Delvin E. et al. Predicting serum vitamin D concentrations based on self-reported lifestyle factors and personal attributes. Br. J. Nutr. 2018; 120(7): 803-12. https://dx.doi.org/10.1017/S000711451800199X.
  19. Yao P., Sun L., Xiong Q., Xu X., Li H., Lin X. Cholecalciferol supplementation promotes bone turnover in Chinese adults with vitamin D deficiency. J. Nutr. 2018; Apr 20. PII: 4979595. https://dx.doi.org/10.1093/jn/nxy032.
  20. Bergman G.J., Fan T., McFetridge J.T., Sen S.S. Efficacy of vitamin D3 supplementation in preventing fractures in elderly women: a meta-analysis. Curr. Med. Res. Opin. 2010; 26(5): 1193-201. https://dx.doi.org/10.1185/03007991003659814.
  21. Pineda-Moncusi M., Garcia-Perez M.A., Rial A., Casamayor G., Cos M.L., Servitja S. et al. Vitamin D levels in Mediterranean breast cancer patients compared with those in healthy women. Maturitas. 2018; 116: 83-8. https://dx.doi.org/10.1016/j.maturitas.2018.07.015.
  22. Janbabai G., Shekarriz R., Hassanzadeh H., Aarabi M., Borhani S.S. A survey on the relationship between serum 25-hydroxy vitamin D level and tumor characteristics in patients with breast cancer. Int. J. Hematol. Oncol. Stem. Cell. Res. 2016; 10(1): 30-6.
  23. Karthikayan A., Sureshkumar S., Kadambari D., Vijayakumar C. Low serum 25-hydroxy vitamin D levels are associated with aggressive breast cancer variants and poor prognostic factors in patients with breast carcinoma. Arch. Endocrinol. Metab. 2018; 62(4): 452-9. https://dx.doi.org/10.20945/2359-3997000000062.
  24. de Sousa Almeida-Filho B., De Luca Vespoli H., Pessoa E.C., Machado M., Nahas-Neto J., Nahas E.A.P. Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women. J. Steroid Biochem. Mol. Biol. 2017; 174: 284-9. https://dx.doi.org/10.1016/j.jsbmb.2017.10.009.
  25. Wang D., Velez de-la-Paz O.I., Zhai J.X., Liu D.W. Serum 25-hydroxyvitamin D and breast cancer risk: a meta-analysis of prospective studies. Tumour Biol. 2013; 34(6): 3509-17. https://dx.doi.org/10.1007/s13277-013-0929-2.
  26. Delle Monache S., Di Fulvio P., Iannetti E., Valerii L., Capone L., Nespoli M.G. et al. Body mass index represents a good predictor of vitamin D status in women independently from age. Clin. Nutr. 2018; Mar 2. pii: S0261-5614(18)30089-X. https://dx.doi.org/10.1016/j.clnu.2018.02.024.
  27. Nabak A.C., Johnson R.E., Keuler N.S., Hansen K.E. Can a questionnaire predict vitamin D status in postmenopausal women? Public Health Nutr. 2014; 17(4): 739-46. https://dx.doi.org/10.1017/S1368980013001973.
  28. Schmitt E.B., Nahas-Neto J., Bueloni-Dias F., Poloni P.F., Orsatti C.L., Petri Nahas E.A. Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women. Maturitas. 2018; 107: 97-102. https://dx.doi.org/10.1016/j.maturitas.2017.10.011.
  29. Valladares T., Cardoso M.R., Aldrighi J.M. Higher serum levels of vitamin D are associated with lower blood glucose levels. Menopause. 2019; Jan 18. https://dx.doi.org/10.1097/GME.0000000000001308.
  30. Sukumar D., Shapses S.A., Schneider S.H. Vitamin D supplementation during short-term caloric restriction in healthy overweight/obese older women: Effect on glycemic indices and serum osteocalcin levels. Mol. Cell. Endocrinol. 2015; 410: 73-7. https://dx.doi.org/10.1016/j.mce.2015.01.002.
  31. Gimigliano F., Moretti A., de Sire A., Calafiore D., Iolascon G. The combination of vitamin D deficiency and overweight affects muscle mass and function in older post-menopausal women. Aging Clin. Exp. Res. 2018; 30(6): 625-31. https://dx.doi.org/10.1007/s40520-018-0921-1.
  32. Cangussu L.M., Nahas-Neto J., Orsatti C.L., Poloni P.F., Schmitt E.B., Almeida-Filho B., Nahas E.A. Effect of isolated vitamin D supplementation on the rate of falls and postural balance in postmenopausal women fallers: a randomized, double-blind, placebo-controlled trial. Menopause. 2016; 23(3): 267-74. https://dx.doi.org/10.1097/GME.0000000000000525.
  33. Hao Y., Ma X., Luo Y., Xu Y., Xiong Q., Zhu J. et al. Inverse association of serum vitamin D in relation to carotid intima-media thickness in Chinese postmenopausal women. PLoS One. 2015; 10(3): e0122803. https://dx.doi.org/10.1371/journal.pone.0122803. eCollection 2015.
  34. Schierbeck L.L., Rejnmark L., Tofteng C.L., Stilgren L., Eiken P., Mosekilde L. et al. Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study. Eur. J. Endocrinol. 2012; 167(4): 553-60. https://dx.doi.org/101530/EJE-12-0283.
  35. Yildirim P., Garip Y., Karci A.A., Guler T. Dry eye in vitamin D deficiency: more than an incidental association. Int. J. Rheum. Dis. 2016; 19(1): 49-54. https://dx.doi.org/10.1111/1756-185X.12727.
  36. Glijer B., Peterfy C., Tenenhouse A. The effect of vitamin D deficiency on secretion of saliva by rat parotid gland in vivo. J. Physiol. 1985; 363: 323-34. https://dx.doi.org/10.1113/jphysiol.1985.sp015713.
  37. Oberg J., Verelst M., Jorde R., Cashman K., Grimnes G. High dose vitamin D may improve lower urinary tract symptoms in postmenopausal women. J. Steroid Biochem. Mol. Biol. 2017; 173: 28-32. https://dx.doi.org/10.1016/j.jsbmb.2017.03.013.
  38. Katano-Toki A., Satoh T., Tomaru T., Yoshino S., Ishizuka T., Ishii S. et al. THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. Mol. Endocrinol. 2013; 27(5): 769-80. https://dx.doi.org/10.1210/me.2012-1332.
  39. Yamaguchi H., Yoshida S., Muroi E., Yoshida N., Kawamura M., Kouchi Z. et al. Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation. J. Cell Biol. 2011; 193(7): 1275-88. https://dx.doi.org/10.1083/jcb.201009126.
  40. Kemmochi S., Fujimoto H., Woo G.H., Hirose M., Nishikawa A., Mitsumori K., Shibutani M. Preventive effects of calcitriol on the development of capsular invasive carcinomas in a rat two-stage thyroid carcinogenesis model. J. Vet. Med. Sci. 2011; 73(5): 655-64.
  41. Kim G., Bae J. Vitamin D and atopic dermatitis: A systematic review and meta-analysis. Nutrition. 2016; 32(9): 913-20. https://dx.doi.org/10.1016/j.nut.2016.01.023.
  42. Muscogiuri G., Palomba S., Caggiano M., Tafuri D., Colao A., Orio F. Low 25 (OH) vitamin D levels are associated with autoimmune thyroid disease in polycystic ovary syndrome. Endocrine. 2016; 53(2): 538-42. https://dx.doi.org/10.1007/s12020-015-0745-0.
  43. Roskies M., Dolev Y., Caglar D., Hier M.P., Mlynarek A., Majdan A., Payne R.J. Vitamin D deficiency as a potentially modifiable risk factor for thyroid cancer. J. Otolaryngol. Head Neck Surg. 2012; 41(3): 160-3.
  44. Roehlen N., Doering C., Hansmann M.L., Gruenwald F., Vorlaender C., Bechstein W.O. et al. Vitamin D, FOXO3a, and Sirtuin1 in hashimoto’s thyroiditis and differentiated thyroid cancer. Front Endocrinol. (Lausanne). 2018; 9: 527. https://dx.doi.org/10.3389/fendo.2018.00527. eCollection 2018.
  45. Рожинская Л.Я. Остеопороз в эндокринологии. Opinion Leader. 2018; 1: 66-8. [Rozhinskaya L.Ya. Osteoporosis in endocrinology. Opinion Leader. 2018; 1: 66-8. (in Russian)].
  46. Лесняк О.М., ред. Профилактика, диагностика и лечение дефицита витамина Д и кальция среди взрослого населения и у пациентов с остеопорозом. Рекомендации Российской ассоциации по остеопорозу. М.: ГЭОТАР-Медиа; 2016. 92 с. [Lesnyak O.M., ed. Prevention, diagnosis and treatment of vitamin D and calcium deficiency in the adult population and in patients with osteoporosis. Recommendations of the Russian Association for Osteoporosis. M .: GEOTAR-Media; 2016. 92 p. (in Russian)].
  47. Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for calcium and Vitamin D. Washington, DC: National Academy Press; 2010.
  48. Hin H., Tomson J., Newman C., Kurien R., Lay M., Cox J. et al. Optimum dose of vitamin D for disease prevention in older people: BEST-D trial of vitamin D in primary care. Osteoporos. Int. 2017; 28(3): 841-51. https://dx.doi.org/10.1007/s00198-016-3833-y.
  49. Gaffney-Stomberg E., Lutz L.J., Shcherbina A., Ricke D.O., Petrovick M., Cropper T.L. et al. Association between single gene polymorphisms and bone biomarkers and response to calcium and vitamin D supplementation in young adults undergoing military training. J. Bone Miner. Res. 2017; 32(3): 498-507. https://dx.doi.org/10.1002/jbmr.3008.
  50. Yao P., Sun L., Lu L., Ding H., Chen X., Tang L. et al. Effects of genetic and nongenetic factors on total and bioavailable 25(ОН)D3 responses to vitamin D supplementation. J. Clin. Endocrinol. Metab. 2017; 102(1): 100-10. https://dx.doi.org/10.1210/jc.2016-2930.

Received 12.04.2019

Accepted 19.04.2019

About the Authors

Gromova, Olga A., MD, professor, science head of the Institute of Pharmacoinformatics, leading researcher of the Department of Intellectual Systems FRCCSC RAS,
Federal Research Center «Computer Science and Control» of Russian Academy of Sciences. 119333, Russian Federation, Moscow, Vavilova str. 42. Tel.: +74997833327. E-mail: unesco.gromova@gmail.com SPIN-код: 6317-9833, AuthorID: 94901,
Scopus Author ID: 7003589812 ORCID iD https://orcid.org/0000-0002-7663-710X, WOS ID J-4946-2017
Torshin, Ivan Yu., PhD in Applied Mathematics, Institute of Pharmacoinformatics.
119333, Russian Federation, Moscow, Vavilova, 42. Tel.: +74997833327. E-mail: tiy135@ccas.ru Scopus Author ID: 7003300274, SPIN-код: 1375-1114
AuthorID: 54104, ORCID iD 0000-0002-2659-7998, WOS ID C-7683-2018
Tetruashvili, Nana K., MD, head of the Department of Pregnancy Loss Prevention and Therapy, Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: tetrauly@mail.ru
Malyvskaya, Svetlana I., MD, professor, head of sciences FGBOU VO SevGMU of the Ministry of Health of Russia, Federal State Budget Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Health of the Russian Federation.
163000, Russia, Arkhangelsk, Troitskiy Ave., 51. Tel.: +78182285791, fax: + 78182286595. E-mail: nauka@nsmu.ru

For citations:Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Malyavskaya S.I. Vitamin D deficiency in adult women. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (5): 170-8. (in Russian)
http://dx.doi.org/10.18565/aig.2019.5.170-178

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.