Vitamin D deficiency in adult women

Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Malyavskaya S.I.

1) Institute of Pharmacoinformatics, Federal Research Center of Informatics and Management, Russian Academy of Sciences, Moscow, Russia; 2) Big Data Storage and Analysis Center, Moscow State University, Moscow, Russia; 3) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia; 4) Northern State Medical University, Ministry of Health of Russia, Arkhangelsk, Russia
The negative effects of vitamin D deficiency are much wider than only increased bone degradation. The paper gives the results of a systematic analysis of 1190 clinical and experimental studies of the effects of inadequate vitamin D supply during the menopausal transition and postmenopause. Vitamin D deficiency has been shown to contribute to the development of metabolic syndrome, breast tumors, muscle strength loss and sarcopenia, rheumatoid arthritis and lipid disturbances. Accordingly, adequate daily supplementation with vitamin D (2000-4000 IU/day) during the menopausal transition and subsequent postmenopause will compensate for vitamin D deficiency and contribute to the prevention of comorbidities.


vitamin D


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Received 12.04.2019

Accepted 19.04.2019

About the Authors

Gromova, Olga A., MD, professor, science head of the Institute of Pharmacoinformatics, leading researcher of the Department of Intellectual Systems FRCCSC RAS,
Federal Research Center «Computer Science and Control» of Russian Academy of Sciences. 119333, Russian Federation, Moscow, Vavilova str. 42. Tel.: +74997833327. E-mail: SPIN-код: 6317-9833, AuthorID: 94901,
Scopus Author ID: 7003589812 ORCID iD, WOS ID J-4946-2017
Torshin, Ivan Yu., PhD in Applied Mathematics, Institute of Pharmacoinformatics.
119333, Russian Federation, Moscow, Vavilova, 42. Tel.: +74997833327. E-mail: Scopus Author ID: 7003300274, SPIN-код: 1375-1114
AuthorID: 54104, ORCID iD 0000-0002-2659-7998, WOS ID C-7683-2018
Tetruashvili, Nana K., MD, head of the Department of Pregnancy Loss Prevention and Therapy, Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail:
Malyvskaya, Svetlana I., MD, professor, head of sciences FGBOU VO SevGMU of the Ministry of Health of Russia, Federal State Budget Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Health of the Russian Federation.
163000, Russia, Arkhangelsk, Troitskiy Ave., 51. Tel.: +78182285791, fax: + 78182286595. E-mail:

For citations:Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Malyavskaya S.I. Vitamin D deficiency in adult women. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (5): 170-8. (in Russian)

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