Obesity during the menopausal transition: how to break negative connections and prevent consequences?

Yureneva S.V.

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

There is growing evidence of a strong connection between the functioning of the female reproductive system and changes in body composition at different periods of life. The presence of obesity significantly changes the clinical course of the menopausal transition and, in turn, the hormonal changes that are characteristic of menopause (hypoestrogenism plus relative hyperandrogenism) may contribute to the development of central/visceral obesity, which may initially be latent if normal weight is maintained. Women should be informed about all possible methods of prevention and treatment of obesity that increases the risk of cardiometabolic disorders and associated severe vasomotor symptoms. These methods include lifestyle changes such as diet, exercise and cognitive-behavioral therapy, menopausal hormone therapy and, if necessary, medication for obesity. It is important to consider the clinical characteristics and risk profile of the individual woman, who can maximize the benefits by choosing the right menopausal hormone therapy product, taking into account its effects on body composition and key metabolic parameters. The progestin drospirenone, part of menopausal hormone therapy as a progestogenic component, primarily promotes weight loss by reducing visceral fat, assists in maintaining body composition, and may counteract atherogenic trends and the associated increases in cardiovascular risk.
Conclusion: The prevention and treatment of obesity in the menopausal transition, as well as the improvement of treatment for menopausal disorders, can positively impact the quality of life and help to maintain women’s long-term health.

Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
For citation: Yureneva S.V. Obesity during the menopausal transition: how to break negative connections and prevent consequences?
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (11): 56-65 (in Russian)
https://dx.doi.org/10.18565/aig.2024.291

Keywords

menopausal transition
postmenopause
obesity
menopausal hormone therapy
drospirenone

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Received 15.11.2024

Accepted 21.11.2024

About the Authors

Svetlana V. Yureneva, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of the Department of Vocational Education; Deputy Director for Science of the Institute of Oncogynecology and Mammology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia, 117997, Russia, Moscow, Oparin str., 4, syureneva@gmail.com, https://orcid.org/0000-0003-2864-066X

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