Modern possibilities for intimate contour correction in reproductive-aged and perimenopausal women
Teterina T.A., Apolikhina I.A., Kazakova S.N., Mikhaylova N.P.
Background: Labia majora augmentation is a primary focus of aesthetic gynecology. Nevertheless, it is advisable to conduct clinical studies in order to standardize the technique of labia majora augmentation.
Objective: To evaluate the short- and long-term outcomes of intimate contour correction of the labia majora in reproductive-aged and perimenopausal women with the use of stabilized hyaluronic acid.
Materials and methods: The prospective observational study included 40 reproductive-aged and perimenopausal women who met the inclusion/exclusion criteria. Depending on age, the study participants were divided into two groups: group 1 (n=20) included women of reproductive age (25–45 years, mean age is 34 years) with lipodystrophy of the labia majora, group 2 (n=20) included perimenopausal women (46–65 years, mean age 52 years) with lipodystrophy of the labia majora and signs of genitourinary syndrome of menopause (GSM). All patients underwent a single injection contouring procedure. The amount of drug injected was 2 ml (1 ml in each labium majora). The observation period was 12 months.
Results: The vaginal health index (VHI) in the group of reproductive-aged women was obviously higher (24.5 points) than in the group of perimenopausal women and did not change significantly during intimate contour correction with HYALUFORM Filler Intimo which contains hyaluronic acid. The group of perimenopausal women with GSM showed an increase in VHI (mostly due to the degree of lubrication and pH) from 17 to 21 points, respectively before and after the injection of HYALUFORM Filler Intimo, despite the lack of direct impact on vaginal tissues. All women had a good tolerance to the filler insertion procedure, no side effects or adverse events were noted.
Conclusion: The main effect of the proposed therapy is the restoration of the anatomical structure (volume), elasticity of the genitals due to the stimulation of elastogenesis and collagenogenesis in the areas of injections and elimination of incompletely closed interlabial space. These outcomes collectively contribute to patient satisfaction.
Authors’ contributions: Apolikhina I.A. – developing the concept and design of the study, editing the text; Teterina T.A., Kazakova S.N., Mikhaylova N.P. – preparing the material, writing the text.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data and associated images.
For citation: Teterina T.A., Apolikhina I.A., Kazakova S.N., Mikhaylova N.P. Modern possibilities for
intimate contour correction in reproductive-aged and perimenopausal women.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (10): 173-182 (in Russian)
https://dx.doi.org/10.18565/aig.2024.247
Keywords
intimate contour correction
lipodystrophy of the labia majora
hyaluronic acid
GSM
postmenopause
aesthetic correction of the vulva
labia majora augmentation
References
- Liao L.M., Creighton S.M. Requests for cosmetic genitoplasty: how should healthcare providers respond? BMJ. 2007; 334(7603): 1090-2. https://dx.doi.org/10.1136/bmj.39206.422269.BE.
- Goodman M.P. Female cosmetic genital surgery. Obstet. Gynecol. 2009; 113(1): 154-9. https://dx.doi.org/10.1097/AOG.0b013e318190c0ea.
- Соколова А.В., Аполихина И.А. Гиалуроновая кислота: перспективы использования в гинекологии. Доктор.Ру. 2021; 20(8): 36-40. [Sokolova A.V., Apolikhina I.A. Hyaluronic acid: prospective use in gynaecology. Doctor.Ru. 2021; 20(8): 36-40. (in Russian)]. https://dx.doi.org/10.31550/1727-2378-2021-20-8-36-40.
- Taieb M., Gay C., Sebban S., Secnazi P. Hyaluronic acid plus mannitol treatment for improved skin hydration and elasticity. J. Cosmet. Dermatol. 2012; 11(2): 87-92. https://dx.doi.org/10.1111/j.1473- 2165.2012.00608.x.
- Lacarrubba F., Tedeschi A., Nardone B., Micali G. Mesotherapy for skin rejuvenation: assessment of the subepidermal low-echogenic band by ultrasound evaluation with cross-sectional В-mode scanning. Dermatol. Ther. 2008; 21(Suppl. 3): S1-S5. https://dx.doi.org/10.1111/j.1529- 8019.2008.00234.x.
- Jabbour S., Kechichian E., Hersant B., Levan P., El Hachem L., Noel W. et al. Labia majora augmentation: a systematic review of the literature. Aesthet. Surg. J. 2017; 37(10): 1157-64. https://dx.doi.org/10.1093/asj/sjx056.
- Лифам В.Дж., Меличер Дж.С. Инъекции ботулотоксина и филлеров в клинической косметологии. Пер. с анг. М.: ГЭОТАР-Медиа; 2019. 176c. [Lifam V.J., Melicher J.S. Botulinus toxin and filler injections in clinical cosmetology. Transl. from English. Мoscow: GEOTAR-Media; 2019. 176p. (in Russian)].
- Buzzaccarini G., Marin L., Noventa M., Vitagliano A., Riva A., Dessole F. et al. Hyaluronic acid in vulvar and vaginal administration: evidence from a literature systematic review. Climacteric. 2021; 24(6): 560-71. https://dx.doi.org/10.1080/13697137.2021.1898580.
- Eserdag S., Akdag Özkok B., Süphan Ersahin S., Zeynep Yilmaz E. Vestibular hyaluronic acid injection in provoked vestibulodynia patients and its effect on pain and sexual function: a preliminary report. Eur. J. Obstet. Gynecol. Reprod. Biol. 2023; 280: 64-7. https://dx.doi.org/10.1016/j.ejogrb.2022.10.027.
- Kolczewski P., Parafiniuk M., Zawodny P., Haddad R., Nalewczyńska A., Kolasa A.K. et al. Hyaluronic acid and radiofrequency in patients with urogenital atrophy and vaginal laxity. Pharmaceuticals (Basel). 2022; 15(12): 1571. https://dx.doi.org/10.3390/ph15121571.
- Berreni N., Salerno J., Chevalier T., Alonso S., Mares P. Evaluation of the effect of multipoint intra-mucosal vaginal injection of a specific cross-linked hyaluronic acid for vulvovaginal atrophy: a prospective bi-centric pilot study. BMC Womens Health. 2021; 21(1): 322. https://dx.doi.org/10.1186/s12905-021-01435-w.
- Hexsel D., DalʼForno T., Caspary P., Hexsel C.L. Soft-tissue augmentation with hyaluronic acid filler for labia majora and mons pubis. Dermatol. Surg. 2016; 42(7): 911-4. https://dx.doi.org/10.1097/DSS.0000000000000733.
- Angelucci M., Frascani F, Franceschelli A., Lusi A., Garo M.L. Efficacy of intradermal hyaluronic acid plus polynucleotides in vulvovaginal atrophy: a pilot study. Climacteric. 2022; 25(5): 490-6. https://dx.doi.org/10.1080/13697137.2022.2052840.
- Zerbinati N., Haddad R.G., Bader A., Rauso R., D'Este E., Cipolla G. et al. A new hyaluronic acid polymer in the augmentation and restoration of labia majora. J. Biol. Regul. Homeost. Agents. 2017; 31(2 Suppl. 2): 153-61.
- Fasola E., Gazzola R. Labia majora augmentation with hyaluronic acid filler: technique and results. Aesthet. Surg. J. 2016; 36(10): 1155-63. https://dx.doi.org/10.1093/asj/sjw083.
- Дикке Г.Б., Бебнева Т.Н., Богдашевская О.В. Депиляция и эпиляция интимной зоны: косметический тренд и медицинский риск. Акушерство и гинекология. 2022; 7: 121-30. [Dikke G.B., Bebneva T.N., Bogdashevskaya O.V. Depilation and epilation of the intimate zone: a cosmetic trend and a medical risk. Obstetrics and Gynecology. 2022; (7): 121-30. (in Russian)]. https://dx.doi.org/10.18565/aig.2022.7.121-130.
- Ayatollahi A., Samadi A., Barikbin B., Saeedi M., Saeedi L., Zamani S. et al. Efficacy and tolerability of a hyaluronic acid-based extracellular matrix for labia majora rejuvenation and augmentation: a pilot study. Cureus. 2024; 16(4): e58970. https://dx.doi.org/10.7759/cureus.58970.
- Казакова С.Н., Аполихина И.А., Тетерина Т.А., Паузина О.А. Применение терапевтического радиочастотного воздействия в гинекологии. Акушерство и гинекология. 2020; 9: 192-8. [Kazakova S.N., Apolikhina I.A., Teterina T.A., Pauzina O.A. Use of therapeutic radiofrequency exposure in gynecology. Obstetrics and Gynecology. 2020; (9): 192-8. (in Russian)]. https://dx.doi.org/10.18565/aig.2020.9.192-198.
Received 08.10.2022
Accepted 14.10.2022
About the Authors
Tatiana A. Teterina, PhD, Obstetrician-gynecologist, USD, Department of Aesthetic Gynecology and Rehabilitation, V.I. Kulakov National Medical Research Centerfor Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Oparina str., 4, +7(963)961-67-44, palpebra@inbox.ru,
https://orcid.org/0000-0003-0990-2302
Inna A. Apolikhina, Dr. Med. Sci., Professor, Head of the Department of Aesthetic gynecology and Rehabilitation, V.I. Kulakov National Medical Research Center
for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Oparina str., 4; Professor at the Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), i_apolikhina@oparina4.ru, https://orcid.org/0000-0002-4581-6295
Svetlana N. Kazakova, PhD, Obstetrician-gynecologist, Atlas Multidisciplinary Medical Center, 121352, Russia, Moscow, Kremenchugskaya str., 3, s-juice@mail.ru,
https://orcid.org/0000-0003-1273-213x
Natalia P. Mikhaylova, PhD, Dermatologist, Aesthetic Physician, Leading Researcher, Martinex International Research and Development Center for Innovative Technologies (ANO IRCIT MARTINEX); Head of the group of aesthetic medicine clinics of Dr. Mikhaylova “Reforma”, mikhailova@martinex.ru, https://orcid.org/0009-0005-4494-0170
Corresponding author: Tatiana A. Teterina, palpebra@inbox.ru
Similar Articles
