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Obstetrics and Gynegology2022№1
Molecular biological bases for intraovarian...

Molecular biological bases for intraovarian folliculogenesis follicular maturation and recruitment

DOI
https://dx.doi.org/10.18565/aig.2022.01.22-30

Sokolova Yu.V., Martirosyan Ya.O., Nazarenko T.A., Biryukova A.M., Khubaeva D.G., Krasnova V.G.

1) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia 2) I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
The review discusses new approaches to studying the stages of folliculogenesis and analyzes the contribution of the major signaling pathways to the processes of intraovarian regulation of folliculogenesis, follicle recruitment and maturation.
Materials and methods: The review includes data from the foreign and Russia articles found in Pubmed on the topic under consideration and published in recent years.
Results: The review analyzes research data on the regulation of the female reproductive system with emphasis on experimental studies of the signaling pathways that regulate intraovarian folliculogenesis and defines prospects for their use in clinical practice. On the basis of new knowledge, the authors consider the possibilities of preventing severe infertility associated with a small number of obtained oocytes and their poor quality, overcoming premature ovarian failure, and protecting the ovaries against gonadotoxic effects. They underline the need for expanding and intensifying the study of the processes of intraovarian folliculogenesis and choosing a gonadotropin-dependent pool of follicles.
Conclusion: The presented studies demonstrate the interest of scientists in the investigation of complex issues of intraovarian folliculogenesis and the role of signaling pathways in this process and touch on molecular genetic involvement and transcriptome analysis. It is necessary to further accumulate this knowledge and conduct fundamental studies for the development of reproductive medicine and the resolution of the problems of reproductive pathology, the situations that we cannot explain now or, therefore, effectively treat.

Keywords

signaling pathways
folliculogenesis
in vitro maturation
Full text (in Russian)

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Received 30.09.2021

Accepted 14.12.2021 

About the Authors

Julia V. Sokolova, embryologist, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynaecology, and Perinatology, Ministry of Health of Russia, +7(495)438-13-41, julietsok@gmail.com, 117997, Russia, Moscow, Ac. Oparina str., 4.
Yana O. Martirosyan, Junior Researcher of the Scientific and Educational Center for ART with the Clinical Division named after F. Paulsen, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynaecology, and Perinatology, Ministry of Health of Russia, +7(925)124-99-99, marti-yana@index.ru, https://orcid.org/0000-0002-9304-4410, 117997, Russia, Moscow, Ac. Oparina str., 4.
Tatiana A. Nazarenko, MD, PhD, Head of the Institute of Reproductive Technologies, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynaecology, and Perinatology, Ministry of Health of Russia, +7(915)322-08-79, t.nazarenko@mail.ru, https://orcid.org/0000-0002-5823-1667, 117997, Russia, Moscow, Ac. Oparina str., 4.
Almina M. Birukova, MD, PhD, Head on Clinical Work of the Scientific and Educational Center for ART with the Clinical Division named after F. Paulsen,
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynaecology, and Perinatology, Ministry of Health of Russia, alma21@list.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Diana G. Khubaeva, student, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), +7(495)622-98-20, khubaeva.d@mail.ru, 119991, Russia, Moscow, Trubetskaya str., 8-2.
Valeria G. Krasnova, student of the Scientific and Educational Center for ART with the Clinical Division named after F. Paulsen, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynaecology, and Perinatology, Ministry of Health of Russia, +7(925)124-99-99, lkrasnova27@mail.com, 117997, Russia, Moscow, Ac. Oparina str., 4.

Authors’ contributions: Sokolova Yu.V., Martirosyan Ya.O., Nazarenko T.A., Biryukova A.M., Khubaeva D.G., Krasnova V.G. - development of the design of the investigation; obtaining data for analysis; review of publications on the topic of the article; analysis of the findings; writing the text of the manuscript.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has not been sponsored.
For citation: Sokolova Yu.V., Martirosyan Ya.O., Nazarenko T.A., Biryukova A.M., Khubaeva D.G., Krasnova V.G. Molecular biological bases for intraovarian folliculogenesis, follicular maturation and recruitment.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 1:22-30 (in Russian)
https://dx.doi.org/10.18565/aig.2022.1.22-30

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