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Obstetrics and Gynegology2021№11
In vitro oocyte maturation

In vitro oocyte maturation

DOI
https://dx.doi.org/10.18565/aig.2021.11.64-70

Mikhailova N.D., Mishieva N.G., Kirillova A.O., Martazanova B.A., Dzhincharade L.G.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
In vitro maturation (IVM) is an assisted reproductive technology (ART) that implies aspiration of immature oocytes and their subsequent in vitro maturation. This technology is of particular importance for patients with polycystic ovary syndrome, as it prevents a formidable complication, such as ovarian hyperstimulation syndrome, as well as for those with resistant syndrome of the ovaries that are unresponsive to gonadotropin stimulation, and for those with cancers due to the possibility to completely abandon any stimulation. Nevertheless, IVM ranks below classical in vitro fertilization (IVF) in efficiency. To enhance the latter of classical IVM, an innovative embryological procedure, a two-stage capacitation in vitro maturation (CAPA-IVM) system that includes a preparatory (pre-IVM) step, has been developed, which contributes to the acquisition of competence by oocytes, and their further cultivation and maturation in the IVM media. This technology has shown to be effective, but it has a rather limited application and at this stage requires further investigation.
Conclusion: This literature review describes the experience and efficiency of IVM and CAPA-IVM procedures including those in comparison with classical IVF in different categories of patients on the basis of Russian and international publications on this topic from the Pubmed system. The choice of the optimal treatment policy for such patients also requires further investigation.

Keywords

infertility
polycystic ovary syndrome
in vitro maturation
capacitation in vitro maturation
gynecology
assisted reproductive technology
in vitro fertilization
Full text (in Russian)

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Received 28.07.2021

Accepted 07.10.2021

About the Authors

Nina D. Mikhaylova, graduate student of 1st Gynecology Department, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia, +7(915)456-81-51, mihailnina@mail.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Nona G. Mishieva, PhD, Senior Researcher of 1st Gynecology Department, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(495)438-26-22, nondoc555@mail.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Anastasia O. Kirillova, PhD, Senior Researcher of 1st Gynecology Department, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(495)531-44-44, a_kozyreva@oparina4.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Bella A. Martazanova, PhD, Junior Researcher of 1st Gynecology Department, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(967)123-88-24, bellamart88@mail.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Lana G. Dzhincharadze, graduate student of 1st Gynecology Department, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(926)073-77-73, lanachka@list.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.

Authors’ contributions: Mishieva N.G., Kirillova A.O. – development and design of the investigation; Mikhailova N.D. – review of publications on the topic of the article; analysis of the findings; writing the text of the manuscript; Kirillova A.O.,
Martazanova B.A., Dzhincharade L.G. – editing.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has been conducted without sponsorship within the framework of N.L. Mikhailova’s thesis research.
For citation: Mikhailova N.D., Mishieva N.G., Kirillova A.O., Martazanova B.A.,
Dzhincharade L.G. In vitro oocyte maturation.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 11: 64-70 (in Russian)
https://dx.doi.org/10.18565/aig.2021.11.64-70

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