New technique in reproductive surgery: one-step surgical procedure for ovarian function activation (first clinical observation)

Adamyan L.V., Dementyeva V.O., Asaturova A.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia, Moscow
A novel surgical procedure for restoring the reproductive potential was performed at the National Medical Centre for Obstetrics, Gynecology and Perinatology in Moscow on March 06, 2019. A 36-year-old patient who experienced premature ovarian failure was operated. Due to the impact of various epigenetic factors (harmful environmental impact, dietary patterns, etc.), there has been an increase in the proportion of young women aged 40 years or younger suffering from premature ovarian failure. It results in inability to achieve pregnancy with their own oocytes, even using assisted reproductive technologies. Scientists around the world are searching for new methods for restoring reproductive function in late reproductive age women and patients with premature ovarian failure.

Keywords

premature ovarian failure
POF
folliculogenesis
reproductive potential
in vitro activation
signaling pathway

References

  1. Baber R.J., Panay N., Fenton A.; IMS Writing Group. 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy. Climacteric. 2016; 19(2): 109-50. https://doi.org/10.3109/13697137.2015.1129166.
  2. Panay N., Kalu E. Management of premature ovarian failure. Best Pract. Res. Clin. Obstet. Gynaecol. 2009; 23(1): 129-40. https://doi.org/10.1016/j.bpobgyn.2008.10.008.
  3. Габибуллаева З.Г. Клинико-генетическая характеристика больных с преждевременной недостаточностью яичников: автореф. дисc. … канд. мед. наук. M.; 2008. [Gabibullaeva Z.G. Clinical and genetic characteristics of patients with premature ovarian failure: author. disc. ... Cand. honey. sciences. M .; 2008 (in Russian)].
  4. Li J., Kawamura K., Cheng Y., Liu S., Klein C., Liu S. et al. Activation of dormant ovarian follicles to generate mature eggs. Proc. Natl. Acad. Sci. USA. 2010; 107(22): 10280-4. https://doi.org/10.1073/pnas.1001198107.
  5. Kawamura K., Cheng Y., Suzuki N., Deguchi M., Sato Y., Takae S. et al. Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc. Natl. Acad. Sci. USA. 2013; 110(43): 17474-9. https://doi.org/10.1073/pnas.1312830110.
  6. Diaz-Garcia C., Pellicer A. Follicle activation in patients with poor ovarian response through fragmentation of the ovarian tissue. 2016. Available at: https://trialbulletin.com/lib/entry/ct-02354963 Accessed July 17, 2018.
  7. Fabregues F., Ferreri J., Calafell J.M., Moreno V., Borrás A., Manau D., Carmona F. Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review J. Ovarian Res. 2018; 11(1): 76. https://doi.org/10.1186/s13048-018-0447-3.
  8. Kawashima I., Kawamura K. Regulation of follicle growth through hormonal factors and mechanical cues mediated by Hippo signaling pathway. Syst. Biol. Reprod. Med. 2018; 64(1): 3-11. https://doi.org/10.1080/19396368.2017.1411990.

Received 15.02.2019

Accepted 22.02.2019

About the Authors

Adamyan, Leyla V., MD, academician of RAS, professor, Honored Master of Science of the Russian Federation, head specialist in Obstetrics and Gynecology of Ministry of Health of Russia, head of Gynecologic Surgery Department, Vice-Director, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954384068.
Dementyeva, Victoria O., postgraduate student, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: victoriadementyeva93@gmail.com
Asaturova, Alexanda V., PhD, pathologist, senior scientific assistant of
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: a_asaturova@oparina4.ru

For citation: Adamyan L.V., Dementyeva V.O., Asaturova A.V. New technique in reproductive surgery: one-step surgical procedure for ovarian function activation (first clinical observation). Akusherstvo i Ginekologiya/Obstetrics and Gynecology.2019; (3): 147-51. (in Russian)
https://dx.doi.org/10.18565/aig.2019.3.147-151

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