Micronutrient status of a pregnant woman: risks associated with deficiency and methods of correction

DOI

https://dx.doi.org/10.18565/aig.2020.5.156-64

Makarova S.G., Kodencova V.M., Ladodo O.B., Prodeus A.P., Basargina M.A., Butskaya T.V., Yasakov D.S.
1) National Medical Research Center for Children’s Health, Ministry of Health of the Russian Federation, Moscow, Russian Federation; 2) N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russian Federation ; 3) Lomonosov Moscow State University, Moscow, Russian Federation ; 4) Federal Research Center for Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; 5) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russian Federation; 6) G.N. Speransky Children’s City Clinical Hospital Nine, Moscow Healthcare Department, Moscow, Russian Federation ; 7) Parent Choice Center for Future and Successful Parents, Moscow, Russian Federation

A mother’s body during pregnancy is the only source of macronutrients and micronutrients for her developing baby. Micronutrient deficiency most critically affects in the first 1000 days of life; that is to say, in the period when nutritional programming per se occurs. Numerous studies conducted in the Russian Federation have shown that vitamin deficiency is detected in a significant portion of pregnant and lactating women. According to the WHO guidelines and Russian clinical practice ones, pregnant women need to take daily iron and folic acid supplements. However, the meta-analyses published in 2017-2019 demonstrate that vitamin-mineral complexes (VMCs) have a more significant beneficial effect on labor outcomes than supplementation with only iron and folic acid. Nutrition experts reason that sufficient evidence has now been accumulated to more widely introduce clinical practice guidelines on VMC supplementation during pregnancy. Estimates show that even with 30% coverage of pregnant women with VMC supplementation, this can prevent a significant number of preterm births, the birth of low birthweight babies, and other unfavorable pregnancy outcomes in the Russian Federation.

pregnant women

babies

micronutrients

vitamin D

vitamin and mineral complexes

supplementation

Full text (in Russian)

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Received 19.05.2020

Accepted 27.05.2020

Svetlana G. Makarova, MD, Head of Department of preventive Pediatrics, National Medical Research Center of Children’s Health; Professor of the Department of faculty Pediatrics, Pirogov medical university; Professor of the Department of fundamental medicine of Moscow state University.
Tel.: +7 (926) 233-26-68. E-mail: sm27@yandex.ru. http://orcid.org/0000-0002-3056-403X.
119991, Russia, Moscow, Lomonosov Av., 2, b. 1.
Vera M. Kodentsova, doctor of biology, Professor, chief researcher of the Laboratory of vitamins and minerals, Federal research center for nutrition, biotechnology and food safety. Tel.: +7 (495) 698-53-30. E-mail: kodentsova@ion.ru. http://orcid.org/0000-0002-5288-1132.
109240, Russia, Moscow, Ustinsky proezd, 2/14.
Olga B. Ladodo, PhD, Head of the «National coordinating center for breast-feeding support», National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I.Kulakov. Tel.: +7(925)508-55-02. E-mail: o_ladodo@oparina4.ru. https://orcid.org/0000-0002-4720-7231.
117997, Russia, Moscow, Akademika Oparina str., 4.
Andrey P. Prodeus, MD, Professor, Chief pediatrician, Children’s city clinical hospital №9 named after G.N. Speransky; Head of the Department of Clinical Immunology and Allergology, Higher Medical School. Tel.: +7(925)-507-25-22. E-mail: prodeus@mail.ru. https://orcid.org/0000-0001-5435-1859.
Milana A. Basargina, senior researcher of the laboratory of neonatology and early childhood health problems, Head of the Department of pathology of newborn children, National Medical Research Center of Children’s Health. E-mail: basargina.ma@nczd.ru. http://orcid.org/0000-0003-2075-6668.
119991, Moscow, Lomonosov Av., 2, b.1.
Tatyana V. Butskaya, General Director of the «Center for future and established parents «Choice of parents», Head of the Committee for mother and child protection of the Eurasian economic community organization. E-mail: tatiana.rodyru@gmail.com. https://orcid.org/0000-0002-6706-1794.
19285, Russia, Moscow, Mosfilmovskaya str., 40.
Dmitry S. Yasakov, researcher of the department of preventive pediatrics, National Medical Research Center for Children’s Health.
E-mail: dmyasakov@mail.ru. http://orcid.org/0000-0003-1330-2828.
119991, Russia, Moscow, Lomonosov Av., 2, b.1.

For reference: Makarova S.G., Kodentsova V.M., Ladodo O.B., Prodeus A.P.,
Basargina M.A., Butskaya T.V., Yasakov D.S. The micronutrient status of a pregnant woman: deficiency-associated risks and correction methods.
Akusherstvo i Ginekologiya. 2020; 5: 156-64 (In Russian).
https://dx.doi.org/10.18565/aig.2020.5.156-64

Micronutrient status of a pregnant woman: risks associated with deficiency and methods of correction

Makarova S.G., Kodencova V.M., Ladodo O.B., Prodeus A.P., Basargina M.A., Butskaya T.V., Yasakov D.S.

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