Use of vitamin D to maintain women’s reproductive health: realities and prospects

Maltseva L.I., Garifullova Yu.V., Yupatov Е.Yu.

1) Kazan State Medical Academy, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Kazan, Russia; 2) Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia
The authors have carried out an analysis of the literature available in the Russian and international databases Scopus, PubMed, and Web of Science, which is devoted to modern views on the abilities of vitamin D to maintain women’s reproductive health. Studying the mechanisms of vitamin D’s effects has made it possible to substantially expand our understanding of the potential preventive and therapeutic effects of the vitamin D hormonal system when following up patients with benign pathology of the reproductive organs. The biological effects of vitamin D are realized through several mechanisms and each is based on regulation of the expression of the genes involved in the processes of cell proliferation and differentiation, immune response, apoptosis, and angiogenesis. The evidence for the high activity of the vitamin D system in the tissues of the ovary, uterus, and breast has confirmed that vitamin D is involved in the local autocrine, paracrine, and endocrine regulation of proliferation and differentiation processes in the tissue; and clinical and experimental studies have demonstrated the effectiveness of vitamin D supplementation in polycystic ovary, uterine fibroids, endometriosis, diffuse mastopathy, and cervical intraepithelial neoplasia. At the same time, correction of vitamin D deficiency can be an effective method for primary prevention of neoplastic processes in the reproductive system, which absolutely necessitates a wide vitamin D screening. However, determination of only the circulating form of the vitamin is not enough to judge its activity at the tissue level; studies of the individual genetic and immunohistochemical parameters of the vitamin D system are needed to develop specific recommendations.


vitamin D
vitamin D receptor
uterine fibroids
polycystic ovary


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Received 11.09.2020

Accepted 16.09.2020

About the Authors

Larisa I. Maltseva, PhD, full professor, Kazan state medical academy – branch of FGBOU DPO RMANPO, Ministry of Health of Russia.
Tel.: +7(843)236-68-92. ORCID: 0000-0003-0999-4374. 36 Butlerova str., Kazan, Russia, 420015.
Yulia V. Garifullova, PhD, assistant, V.S. Gruzdev Department of Obstetrics and Gynecology, Kazan state medical university. Tel.: +7(843)236-08-73.
E-mail: ORCID: 0000-0002-4336-7828. 49 Butlerova str., Kazan, Russia, 420012.
Evgenii Yu. Iupatov, PhD, assistant professor, Head of the Department of obstetrics and gynecology, Kazan state medical academy – branch of FGBOU DPO RMANPO, Ministry of Health of Russia. Tel.: +7(843)236-68-92. E-mail: ORCID: 0000-0001-8945-8912.
36 Butlerova str., Kazan, Russia, 420015.

For citation: Maltseva L.I., Garifullova Yu.V., Yupatov Е.Yu. Use of vitamin D to maintain women’s reproductive health: realities and prospects.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 10: 174-181 (in Russian).

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