Experience with the vitamin-mineral complex “Pregnomama” in women with physiological pregnancy
Objective. Vitamin and mineral complexes (VMCs) are effective in reducing the risk of pregnancy pathology. The effects of VMCs in physiological pregnancy have not been studied in practice.Gromova O.A., Pesegova E.V., Torshin I.Yu., Tetruashvili N.K.
Materials and methods. Women with physiological pregnancy (n=108) were divided into two groups: 1) 54 patients who received the VMC “Pregnomama” (a study group) and 2) 54 patients who took folic acid and potassium iodide throughout the entire pregnancy (a control group). The VMC “Pregnomama” contains 200 mg of omega-3 polyunsaturated fatty acid (PUFA): docosahexaenoic acid (DHA). The female participants’ condition was assessed at 4, 12, 24, and 32 weeks of pregnancy and at 42 days after its resolution, by using the data of anthropometry, biochemical blood test, and Health Status, Activity, and Mood (HSAM) and SF-36 psychophysiological questionnaires.
Results. By the end of the study, the study group patients compared with the controls had more HSAM scores in the sections “Activity” (+5.0, P=3.5×10-5), “Mood” (+3.8, P=8.3×10-5), “Health Status” (+3.4, P=7.5×10-7) and in the section “Physical Component of Health” of the SF-36 scale (+3.7, P=5.8×10-5). The greatest increase in the SF-36 score was observed in the sections “Role-physical functioning” (+21.3, P=0.0002) and "Social functioning" (+8.3, P=0.0095). The increase in the values of the above indicators was associated with a rise in the omega-3 blood index (P=1.3×10-6) primarily due to the elevated concentration of DHA (+0.48%, P=9.6×10-6). The number of female participants with the normal omega-3 index (more than 4%) increased when taking the VMC “Pregnomama” (from 70 to 91%) and decreased in the controls (from 72 to 61%; P=0.0001). Significant dynamics of ferritin concentrations in the blood was noted already by the 12th week of pregnancy (the main group is 88.8±35.2 ng/ml, the control group is 64.0±30.3 ng/ml; P=7,8×10-5).
Conclusion. The VMC “Pregnomama” is effective in maintaining the psychophysiological status during normal current pregnancy and is safe throughout the entire pregnancy.
Keywords
micronutrients
docosahexaenoic acid
pregnancy
psychosomatics
randomized trial
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Received 26.05.2021
Accepted 03.06.2021
About the Authors
Olga A. Gromova, Dr. Med. Sci., Professor, Science Нead of the Institute of Pharmacoinformatics, Leading Researcher of the Department of Intellectual Systems, Federal Research Center “Computer Science and Control” of Russian Academy of Sciences. E-mail: unesco.gromova@gmail.com. ORCID: 0000-0002-7663-710X.119333, Russia, Moscow, Vavilova str., 42.
Evgenia V. Pesegova, gynecologist, AltraVita IVF Clinic, Moscow, Russia. 117186, Russia, Moscow, Nagornaya str., 4A.
Ivan Yu. Torshin, PhD in Applied Mathematics, Institute of Pharmacoinformatics, Senior Researcher of the Department of Intellectual Systems, Federal Research Center “Computer Science and Control” of Russian Academy of Sciences. ORCID: 0000-0002-2659-7998. 119333, Russia, Moscow, Vavilova str., 42.
Nana K. Tetruashvili, Dr. Med. Sci., Head of the 2nd Obstetrics Department of Pathology of Pregnancy, V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia. E-mail: n_tetruashvili@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
For citation: Gromova O.A., Pesegova E.V., Torshin I.Yu., Tetruashvili N.K. Experience with the vitamin-mineral complex “Pregnomama” in women with physiological pregnancy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 6: 122-130 (in Russian)
https://dx.doi.org/10.18565/aig.2021.6.122-130
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