Gene methylation in the placenta of fetuses with fetal growth restriction

1. Barker D.J.P., Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986; 10, 1(8489): 1077–81. doi: 10.1016/s0140-6736(86)91340-1
2. Kwon E.J., Kim Y.J. What is fetal programming: a lifetime health is under the control of in utero health. Obstet Gynecol Sci. 2017; 60(6): 506–19. doi: 10.5468/ogs.2017.60.6.506
3. Hales C.N., Barker D.J.P. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Int J Epidemiol. 2013; 42(5): 1215–22 doi: 10.1093/ije/dyt133
4. Дегтярева Е.И., Григорян О.Р., Волеводз Н.Н., Андреева Е.Н., Клименченко Н.И., Мельниченко Г.А., Дедов И.И., Сухих Г.Т. Роль импринтинга генов при внутриутробной задержке роста плода. Акушерство и гинекология. 2015; 12: 5–10. [Degtyareva E.I., Grigoryan O.R., Volevodz N.N., Andreeva E.N., Klimenchenko N.I., Melnichenko G.A., Dedov I.I., Sukhikh G.T. Role of gene imprinting in intrauterine growth restriction. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2015; 12: 5–10.(in Russian)].
5. Marciniak A., Patro-Małysza J., Kimber-Trojnar Ż., Marciniak B., Oleszczuk J., Leszczyńska-Gorzelak B. Fetal programming of the metabolic syndrome. Taiwan J Obstet Gynecol. 2017; 56(2):133–8. doi: 10.1016/j.tjog.2017.01.001
6. Menendez-Castro C., Rascher W., Hartner A. Intrauterine growth restriction - impact on cardiovascular diseases later in life. Mol Cell Pediatr. 2018; 5(1): 4. doi: 10.1186/s40348-018-0082-5
7. Faa G., Manchia M., Pintus R., Gerosa C., Marcialis M.A.,Fanos V. Fetal programming of neuropsychiatric disorders.Birth Defects Res C Embryo Today. 2016; 108(3): 207–223. doi: 10.1002/bdrc.21139
8. Feil R., Fraga M.F. Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet. 2012;13(2): 97–109. doi: 10.1038/nrg3142.
9. Manolio T. A., Collins F.S., Cox N.J., Goldstein D.B., Hindorff L.A., Hunter D.J. et al. Finding the missing heritability of complex diseases.Nature. 2009; 461(7265): 747–53. doi: 10.1038/nature08494
10. Salam R.A., Das J.K., Bhutta Z.A. Impact of intrauterine growth restriction on long-term health. Curr Opin Clin Nutr Metab Care. 2014;17(3): 249–54. doi: 10.1097/MCO.0000000000000051
11. Chen P.Y., Ganguly A., Rubbi L., Orozco L.D., Morselli M., Ashraf D., et al. Intrauterine calorie restriction affects placental DNA methylation and gene expression. Physiol Genomics. 2013; 45(14): 565–76. doi: 10.1152/physiolgenomics.00034.2013
12. Banister C.E., Koestler D.C., Maccani M.A., Padbury J.F., Houseman E.A., Marsit C.J. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics. 2011; 6(7): 920–7. doi: 10.4161/epi.6.7.16079
13. Vaiman D. Genes, epigenetics and miRNA regulation in the placenta. Placenta. 2017; 52:127–33. doi: 10.1016/j.placenta.2016.12.026
14. Marsit C.J. Placental epigenetics in children’s environmental health. Semin Reprod Med. 2016; 34(1): 36–41. doi:10.1055/s-0035-1570028
15. Lillycrop K.A., Burdge G.C. Environmental challenge, epigenetic plasticity and the induction of altered phenotypes in mammals. Epigenomics. 2014; 6(6): 623–36. doi: 10.2217/epi.14.51
16. Nelissen E.C.M., van Montfoort A.P., Dumoulin J.C., Evers J.L. Epigenetics and the placenta. Hum Reprod Update. 2011;17(3): 397–417. doi: 10.1093/humupd/dmq052
17. Moore L.D., Le T., Fan G. DNA methylation and its basic function. Neuropsychopharmacology. 2013; 38(1): 23–38. doi: 10.1038/npp.2012.112
18. Wojdacz T.K., Dobrovic A., Hansen L.L. Methylation-sensitive high-resolution melting. Nat Protoc. 2008 3(12):1903–8. doi: 10.1093/nar/gkm013
19. Красный А.М., Садекова А.А., Волгина Н.Е., Машаева Р.И., Кометова В.В., Хабас Г.Н., Голицына Ю.С., Носова Ю.В., Оводенко Д.Л. Исследование уровня метилирования гена RASSF1 в плазме и опухоли при раке эндометрия. Бюллетень экспериментальной биологии и медицины. 2019; 2: 223–7. [Krasnyi A.M., Sadekova A.A., Volgina N.E., Mashaeva R.I., Kometova V.V., Khabas G.N., Golitsyna Yu.S., Nosova Yu.V., Ovodenko V.L.. Investigation of the level of methylation of the RASSF1 gene in plasma and tumor in endometrial cancer. Bulletin of Experimental Biology and Medicine. 2019; (2): 223–7. (in Russian)]
20. Ma Y., Krikun G., Abrahams V.M., Mor G., Guller S. Cell type-specific expression and function of toll-like receptors 2 and 4 in human placenta: implications in fetal infection. Placenta. 2007; 28(10): 1024–31. doi: 10.1016/j.placenta.2007.05.003
21. Erboga M., Kanter M. Trophoblast cell proliferation and apoptosis in placental development during early gestation period in rats. Anal Quant Cytopathol Histpathol. 2015; 37(5): 286–94.
22. Koga K., Aldo P.B., Mor G. Toll‐like receptors and pregnancy: trophoblast as modulators of the immune response. J Obstet Gynaecol Res. 2009; 35(2): 191–202. doi: 10.1111/j.1447-0756.2008.00963.x
23. Abrahams V.M., Bole-Aldo P., Kim Y.M., Straszewski-Chavez S.L., Chaiworapongsa T., Romero R., et al. Divergent trophoblast responses to bacterial products mediated by TLRs. J Immunol. 2004; 173(7): 4286–96. doi: 10.4049/jimmunol.173.7.4286
24. Silva J.F., Ocarino N.M., Serakides R. Spatiotemporal expression profile of proteases and immunological, angiogenic, hormonal and apoptotic mediators in rat placenta before and during intrauterine trophoblast migration. Reprod Fertil Dev. 2017; 29(9): 1774–86. doi:10.1071/RD16280
25. Tycko B. Imprinted genes in placental growth and obstetric disorders. Cytogenet Genome Res. 2006; 113(1–4): 271–8. doi: 10.1159/000090842
26. John R.M. Imprinted genes and the regulation of placental endocrine function: Pregnancy and beyond. Placenta. 2017; 56: 86–90. doi: 10.1016/j.placenta.2017.01.099
27. Christians J.K., Leavey K., Cox B.J. Associations between imprinted gene expression in the placenta, human fetal growth and preeclampsia. Biol Lett. 2017;13(11): pii: 20170643.doi: 10.1098/rsbl.2017.0643
28. Bartholdi D., Krajewska-Walasek M., Ounap K., Gaspar H., Chrzanowska K.H., Ilyana H. et al. Epigenetic mutations of the imprinted IGF2-H19 domain in Silver–Russell syndrome (SRS): results from a large cohort of patients with SRS and SRS-like phenotypes. J Med Genet. 2009; 46(3): 192–7. doi: 10.1136/jmg.2008.061820
29. Du M., Zhou W., Beatty L.G., Weksberg R., Sadowski P.D., et al. The KCNQ1OT1 promoter, a key regulator of genomic imprinting in human chromosome 11p15. 5. Genomics. 2004; 84(2): 288–300. DOI: 10.1016/j.ygeno.2004.03.008
30. Koukoura O., Sifakis S., Soufla G., Zaravinos A., Apostolidou S., Jones A., et al. Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction. Int J Mol Med. 2011; 28(4): 481–7. doi: 10.3892/ijmm.2011.754.
31. Tabano S., Colapietro P., Cetin I., Grati F.R., Zanutto S., Mandò C., Antonazzo P. et al. Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction. Epigenetics. 2010; 5(4): 313–24. DOI: 10.4161/epi.5.4.11637
32. Xiao X., Zhao Y., Jin R., Chen J., Wang X., et al. Fetal growth restriction and methylation of growth-related genes in the placenta. Epigenomics. 2016; 8(1): 33–42. doi: 10.2217/epi.15.101.
33. St-Pierre J., Hivert M.F., Perron P., Poirier P., Guay S.P., Brisson D., et al. IGF2 DNA methylation is a modulator of newborn’s fetal growth and development. Epigenetics. 2012; 7(10): 1125–32. doi: 10.4161/epi.21855.

Received 20.06.2019

Accepted 21.06.2016