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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2020№1
Maternal hemodynamics and preeclampsia

Maternal hemodynamics and preeclampsia

DOI
https://dx.doi.org/10.18565/aig.2020.1.5-11

Nagoev T.M., Muminova K.T., Khodzhaeva Z.S., Kholin A.M., Ziganshina M.M., Kozlova A.A., Martirosyan Ya.O.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
The paper includes scientific publications (mainly systematic reviews and meta-analyses) by foreign and Russian authors over the past 10 years, which have been found in the Pubmed database and on other available search platforms, such as Cochrane, Web of Science, MedLine, and Google Scholar, based on which the paper generalizes and updates the existing data on the features of maternal hemodynamics in preeclampsia (PE), the possibility of its early prediction and choice of therapy, by taking into consideration the indicators of the maternal cardiovascular system. It presents the possibilities of studying maternal hemodynamics using its current indicators, as well as new approaches to elucidating its role in the pathogenesis of early and late PE and data on the possible effect of the endothelial glycocalyx on the hemodynamic profile of a pregnant woman. Further studies are needed to stratify women according to their hemodynamic profile, by simultaneously investigating the endothelial glycocalyx in order to elucidate the role of maternal hemodynamics in the genesis of PE and by elaborating individualized therapeutic approaches.

Keywords

hemodynamics
pregnancy
augmentation index (Aix)
aortic pulse wave velocity (PWV)
stiffness index
endothelial glycocalyx
antihypertensive therapy
Full text (in Russian)

References

  1. Verburg P.E., Roberts C.T., McBean E., Mulder M.E., Leemaqz S., Erwich J.J.H.M., Dekker G.A. Peripheral maternal haemodynamics across pregnancy in hypertensive disorders of pregnancy, Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health (2019); S2210-7789(18)30148-X
  2. Hausvater A., Giannone T., Sandoval Y.H.G., Doonan R.J., Antonopoulos C.N., Matsoukis I.L., Petridou E.T., Daskalopoulou S.S. The association between preeclampsia and arterial stiffness. J. Hypertens. 2012; 30:17–33. doi: 10.1097/HJH.0b013e32834e4b0f.
  3. Khalil A., Cowans N.J., Spencer K., Goichman S., Meiri H., Harrington K. First-trimester markers for the prediction of preeclampsia in women with a-priori high risk, Ultrasound Obstet. Gynecol. 2010; 35: 671–9. doi: 10.1002/uog.7559.
  4. Thilaganathan B. Pre-eclampsia and the cardiovascular–placental axis. Ultrasound Obstet Gynecol. 2018; 51: 714–7. Steegers E, Dadelszen P, Duvekot J, Pijnenborg R. Pre-eclampsia. Lancet. 2010; 376: 631-644. doi: 10.1016/S0140-6736(10)60279-6.
  5. Steegers E, Dadelszen P, Duvekot J, Pijnenborg R. Pre-eclampsia. Lancet. 2010; 376: 631-644. doi: 10.1016/S0140-6736(10)60279-6.
  6. Buurma A.J., Turner R.J., Driessen J.H.M., Mooyaart A.L., Schoones J.W., Bruijn J.A., Bloemenkamp K.W., Dekkers O.M., Baelde H.J. Genetic variants in pre-eclampsia: a meta-analysis. Hum Reprod Update.. 2013; 19(3): 289–303. doi: 10.1093/humupd/dms060
  7. Johnson M.P., Brennecke S.P., East C.E., et al; FINNPEC Study Group. Genetic dissection of the pre-eclampsia susceptibility locus on chromo- some 2q22 reveals shared novel risk factors for cardiovascular disease. Mol Hum Reprod. 2013;19: 423–37. doi: 10.1093/molehr/gat011.
  8. Staff A.C., Redman C.W.G., Williams D., Leeson P., Moe K., Thilaganathan B., Roberts J.M. Pregnancy and Long-Term Maternal Cardiovascular Health. Hypertension. 2016; 67(2): 251–60. doi: 10.1161/HYPERTENSIONAHA.115.06357.
  9. Mounier-Vehier C., Madika A.-L., Boudghène-Stambouli F., Ledieu G., Delsart P., Tsatsaris V. Hypertensions artérielles de la grossesse et devenir maternel. La Presse Médicale. 2016; 45(7–8): 659–66. doi: 10.1016/j.lpm.2016.05.017
  10. Sanghavi M., Rutherford J.D. Cardiovascular Physiology of Pregnancy. Circulation. 2014; 130(12):1003–8. doi: 10.1161/CIRCULATIONAHA.114.009029.
  11. Mahendru A.A., Everett T.R., Wilkinson I.B., Lees C.C., McEniery C.M. A lon- gitudinal study of maternal cardiovascular function from preconception to the postpartum period. J Hypertens. 2014; 32: 849–56. doi: 10.1097/HJH.0000000000000090.
  12. Grindheim G., Estensen M.E., Langesaeter E., Rosseland L.A., Toska K. Changes in blood pressure during healthy pregnancy: a longitudinal cohort study. J Hypertens. 2012; 30: 342–350.
  13. Jia R.Z., Liu X.M., Wang X., Wu H.Q. Relationship between cardiovascular function and fetal growth restriction in women with preeclampsia. Int J Gynaecol Obstet. 2010; 110: 61–3. doi: 10.1016/j.ijgo.2010.02.007
  14. Valensise H., Vasapollo B., Gagliardi G., Novelli G.P. Early and late preeclamp- sia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension. 2008; 52: 873–80. doi: 10.1161/HYPERTENSIONAHA.108.117358
  15. Stott D., Nzelu O., Nicolaides K.H., Kametas N.A. Maternal haemodynamics in normal pregnancies and in pregnancies affected by pre-eclampsia: Maternal haemodynamics in pre-eclampsia with FGR.  Ultrasound Obstet Gynecol. 2017; 52(3): 302–3. doi: 10.1002/uog.18835
  16. Melchiorre K., Thilaganathan B. Maternal cardiac function in preeclampsia. Curr Opin Obstet Gynecol. 2011; 23(6): 440-7. doi: 10.1097/GCO.0b013e32834cb7a4.
  17. Foo F.L., McEniery C.M., Lees, C., Khalil A. Assessment of arterial function in pregnancy: recommendations of the International Working Group on Maternal Hemodynamics. Ultrasound Obstet Gynecol. 2017; 50(3): 324–31. doi: 10.1002/uog.17565.
  18. Van Bortel L.M., Laurent S., Boutouyrie P., Chowienczyk P., Cruickshank J.K., De Backer T., Filipovsky J., Huybrechts S., Mattace-Raso F.U., Protogerou A.D., Schillaci G., Segers P., Vermeersch S., Weber T., Artery S. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012; 30: 445–8 https://doi.org/10.1097/HJH.0b013e32834fa8b0
  19. Hausvater A., Giannone T., Sandoval Y.H., Doonan R.J., Antonopoulos C.N., Matsoukis I.L., Petridou E.T., Daskalopoulou S.S. The association between preeclampsia and arterial stiffness. J Hypertens. 2012; 30:17–33. doi: 10.1097/HJH.0b013e32834e4b0f.
  20. Khalil A., Garcia-Mandujano R., Maiz N., Elkhouli M., Nicolaides K.H. Longitudinal changes in maternal hemodynamics in a population at risk for pre-eclampsia. Ultrasound Obstet Gynecol. 2014; 44: 197–204. doi: 10.1002/uog.13367
  21. Savvidou M.D., Kaihura C., Anderson J.M., Nicolaides K.H. Maternal arterial stiffness in women who subsequently develop pre-eclampsia. PLoS One. 2011; 6(5): e18703. doi: 10.1371/journal.pone.0018703
  22. Khalil A., Akolekar R., Syngelaki A., Elkhouli M., Nicolaides K.H. Maternal hemodynamics at 11-13 weeks’ gestation and risk of pre-eclampsia. Ultrasound Obstet Gynecol. 2012; 40: 28–34. doi: 10.1002/uog.11183
  23. Osman M.W., Nath M., Breslin E., Khalil A., Webb D.R., Robinson, T.G., Mousa H.A. Association between arterial stiffness and wave reflection with subsequent development of placental-mediated diseases during pregnancy. Journal of Hypertension. 2018: 36(5); 1005–14. doi: 10.1097/HJH.0000000000001664
  24. Melchiorre A.-K., Sharma R., Thilaganathan B. Cardiovascular implica- tions in preeclampsia: an overview. Circulation. 2014; 130: 703–714. doi: 10.1161/CIRCULATIONAHA.113.003664.
  25. Wikström A.-K., Svensson T., Kieler H., et al. Recurrence of placental dysfunction disorders across generations. Am J Obstet Gynecol. 2011; 205: 454.e1-8. doi: 10.1016/j.ajog.2011.05.009.
  26. Thilaganathan B. Association of Higher Maternal Blood Pressure With Lower Infant Birthweight: Placental Cause or Cardiovascular Effect? Hypertension. 2016; 67(3): 499–500. doi:10.1161/HYPERTENSIONAHA.115.06880
  27. Pathak S., Lees C.C., Hackett G., Jessop F., Sebire N.J. Frequency and clinical sig- nificance of placental histological lesions in an unselected population at or near term. Virchows Arch. 2011; 459: 565–72. doi:10.1007/s00428-011-1157-z
  28. Heida K.Y., Franx A., van Rijn B.B., Eijkemans M.J., Boer J.M., Verschuren M.W., Oudijk M.A., Bots M.L., van der Schouw Y.T. Earlier age of onset of chronic hypertension and type 2 diabetes mellitus after a hypertensive disorder of pregnancy or gestational diabetes mellitus. Hypertension. 2015; 66:1116–22. doi: 10.1161/HYPERTENSIONAHA.115.06005
  29. Romundstad P.R., Magnussen E.B., Smith G.D., Vatten L.J. Hypertension in pregnancy and later cardiovascular risk: common antecedents? Circulation 2010; 122(6): 579–84. doi: 10.1161/CIRCULATIONAHA.110.943407
  30. Roeters van Lennep J.E., Heida K.Y., Bots M.L. Hoek A; collaborators of the Dutch Multidisciplinary Guideline Development Group on Cardiovascular Risk Management after Reproductive Disorders. Cardiovascular disease risk in women with premature ovarian insufficiency: a systematic review and meta-analysis. Eur J Prev Cardiol. 2016; 23(2): 178–86. doi: 10.1177/2047487314556004.
  31. Sullivan S.D., Sarrel P.M., Nelson L.M. Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause. Fertil Steril 2016; 106(7): 1588–99. doi: 10.1016/j.fertnstert.2016.09.046.
  32. Kalafat E., Laoreti A., Khalil A., Da Silva Costa, F., Thilaganathan B. Ophthalmic artery Doppler for prediction of pre-eclampsia: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018; 51(6):731–7. doi:10.1002/uog.19002
  33. Smith R.D., Levy P., Ferrario C.M. Consideration of Noninvasive Hemodynamic Monitoring to Target Reduction of Blood Pressure Levels Study Group. Value of noninvasive hemodynamics to achieve blood pres- sure control in hypertensive subjects. Hypertension. 2006; 47: 771–7. DOI: 10.1161/01.HYP.0000209642.11448.e0
  34. Taler S.J., Textor S.C. Augustine J.E. Resistant hypertension: compar- ing hemodynamic management to specialist care. Hypertension. 2002; 39: 982–8. doi: 10.1161/01.hyp.0000016176.16042.2f
  35. Valensise H., Vasapollo B., Gagliardi G., Novelli G.P. Early and late pre- eclampsia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension. 2008; 52: 873–80. doi: 10.1161/HYPERTENSIONAHA.108.117358
  36. Henderson J.T., Whitlock E.P., O’Connor E., Senger C.A., Thompson J.H., Rowland M.G. Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2014; 160(10): 695–703. doi: 10.7326/M13-2844.
  37. Askie L.M., Duley L., Henderson-Smart D.J., Stewart L.A.; PARIS Collaborative Group. Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data. Lancet. 2007; 369(9575):1791–8. doi: 10.1016/S0140-6736(07)60712-0.
  38. Rolnik D.L., Wright D., Poon L.C., et al. Aspirin versus placebo in pregnan- cies at high risk for preterm preeclampsia. N Engl J Med. 2017; 377(7): 613– 22. doi: 10.1056/NEJMoa1704559.
  39. American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013; 122(5):1122–31. doi: 10.1097/01.AOG.0000437382.03963.88.
  40. Duley L., Meher S., Jones L. Drugs for treatment of very high blood pres- sure during pregnancy. Cochrane Database Syst Rev. 2013; (3): CD001449. DOI: 10.1002/14651858.CD001449.pub2
  41. Webster L.M., Myers J.E., Nelson-Piercy C., Harding K. Cruickshank J.K., Watt-Coote I., Khalil A., Wiesender C., Seed P.T., Chappell L.C. Labetalol versus nifedipine as antihypertensive treatment for chronic hypertension in pregnancy: a randomized controlled trial. Hypertension. 2017; 70: 915– 922. doi:10.1016/j.preghy.2019.05.004
  42. Abalos E., Duley L., Steyn D.W. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev. 2014; (1): CD002252. doi: 10.1002/14651858.CD002252.pub2
  43. Stott D., Papastefanou I., Paraschiv D., Clark K., Kametas N.A. Serial hemodynamic monitoring to guide treatment of maternal hypertension leads to reduction in severe hypertension. Ultrasound Obstet Gynecol. 2017; 49(1): 95–103. doi: 10.1002/uog.17341.
  44. McLaughlin, K., Scholten, R.R., Kingdom, J.C., Floras, J.S., Parker, J.D. Should Maternal Hemodynamics Guide Antihypertensive Therapy in Preeclampsia? Hypertension. 2018; 71(4): 550–6. doi:10.1161/HYPERTENSIONAHA.117.10606
  45. Goulopoulou S., Davidge S.T. Molecular mechanisms of maternal vascular dysfunc- tion in preeclampsia. Trends Mol Med. 2015; 21(2): 88–97. oi: 10.1016/j.molmed.2014.11.009.
  46. Noble M.I., Drake-Holland A.J., Vink H. Hypothesis: arterial glycocalyx dysfunction is the first step in the atherothrombotic process. QJM. 2008; 101(7): 513–8. doi: 10.1093/qjmed/hcn024
  47. Weissgerber T.L., Garcia Valencia O., Milic N.M., Codsi E., Cubro H.,Nath M.C., Garovic V.D. Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion. J Am Heart Assoc. 2019; 8(4): e010647. doi: 10.1161/JAHA.118.010647.

Received 19.06.2019

Accepted 21.06.2019

About the Authors

Temirlan M. Nagoev, Postdoc of High Risk Pregnancy Department «National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov» Ministry of Healthcare of Russia. Tel.: +7 (495) 438-0674. E-mail: tamn94@mail.ru
Academica Oparina st. 4, 117997, Moscow, Russia.
Kamilla T. Muminova, Junior researcher of High Risk Pregnancy Department «National Medical Research Center for Obstetrics, Gynecology and Perinatology named
after Academician V.I. Kulakov» Ministry of Healthcare of Russia. Tel.: +7 (495) 438-0674. E-mail:kamika91@mail.ru
Academica Oparina st. 4, 117997, Moscow, Russia
Zulfiya S. Khodzhaeva, MD , Professor, Head of High Risk Pregnancy Department. «National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov» Ministry of Healthcare of Russia. Tel.: +7(495)4380788. E-mail: zkhodjaeva@mail.ru
Academica Oparina st. 4, 117997, Moscow, Russia.
Alexey M. Kholin, obstetrician-gynecologist, High Risk Pregnancy Department. «National Medical Research Center for Obstetrics, Gynecology and Perinatology named
after Academician V.I. Kulakov» Ministry of Healthcare of Russia. Tel.: +7(495)4380788. E-mail: a_kholin@oparina4.ru
Academica Oparina st. 4, 117997, Moscow, Russia.
Marina M. Ziganshina, Senior researcher. Dept of clinical immunology. «National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov» Ministry of Healthcare of Russia. Tel.: +7(495)4380788. E-mail: m_ziganshina@oparina4.ru
Academica Oparina st. 4, 117997, Moscow, Russia.
Anastasiya А. Kozlova, resident of the «National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I Kulakov»
Ministry of Healthcare of Russia. Tel.: +7 (495)438-0674. E-mail: aakozlova.box@gmail.com
Academica Oparina st. 4, 117997, Moscow, Russia.
Yana O. Martirosyan, clinical resident of the Department of Obstetrics, Gynecology, Perinatology and Reproductive medicine of the Medical Faculty, I.M. SechenovFirst Moscow State Medical University (Sechenov University), Ministry of Health of Russia. Tel.: +7(916)950-0745. E-mail marti-yana@index.ru
117997, Russian, Moscow, Ac. Oparina str. 4

For citation: Nagoev T.M., Muminova K.T., Khodzhaeva Z.S., Kholin A.M., Ziganshina M.M., Kozlova A.A., Martirosyan Ya.O. Maternal hemodynamics and preeclampsia.
Akusherstvo i Ginekologiya/Obstetrics and gynecology. 2020; 1: 5-11. (In Russian).
https://dx.doi.org/10.18565/aig.2020.1.5-11

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