Minimally invasive diagnosis of vulvar disease using punch biopsy
Objective. To study the pattern of external genital diseases in women by referrals and to evaluate the efficiency of punch biopsy for the diagnosis of vulvar diseases.Apolikhina I.A., Sokolova A.V., Musaeva A.K., Zaitsev N.V.
Subjects and methods. The investigation enrolled 138 patients aged 20 to 72 years (mean age, 48.0±13.3 years), who underwent vulvar punch biopsy in 2014 to 2019. The inclusion criteria were diagnosed and histologically verified vulvar diseases; 18 years of age and older; non-use of topical corticosteroids within 30 days prior to a biopsy; All the women filled out an informed consent form for vulvar biopsy.
Results. The study showed the high safety and efficiency of punch biopsy in the diagnosis of vulvar diseases, among which, vulvar lichen sclerosus (62.8%) was the most common disease.
Conclusions. Vulvar punch biopsy followed by histologic examination allows the final diagnosis to be established. The advantages of punch biopsy are minimal invasiveness, high safety, obtaining tissue of uniform column shape, and ease of use.
Keywords
vulvar biopsy
punch biopsy
vulvar lichen sclerosus
vulvar cancer
vulvar dermatoses
References
- Haefner H.K., Welch K.C., Rolston A.M., Koeppe E.S.,. Stoffel E.M., Kiel M.J., Berger M.B. Genomic profiling of vulvar lichen sclerosus patients shows possible pathogenetic disease mechanisms. J. Low. Genit. Tract Dis. 2019; 23(3): 214-9. https://dx.doi.org/10.1097/LGT.0000000000000482.
- Люцко В.В. Биопсия кожи в дерматологии. Современные проблемы здравоохранения и медицинской статистики. 2015; 4: 45-55. [Liutsko V.V. Skin biopsy in dermatology. Current problems of health care and medical statistics. 2015; 4: 45-55. (in Russian)].
- Lynch P., Moyal-Barracco M., Scurry J., Stockdale C. 2011 ISSVD terminology and classification of vulvar dermatological disorders. J. Low. Genit. Tract Dis. 2012; 16(4): 339-44. https://dx.doi.org/10.1097/LGT.0b013e3182494e8c.
- Neill S.M., Lewis F.M., Tatnall F.M., Cox N.H. British Association of Dermatologists’ guidelines for the management of lichen sclerosus. Br. J. Dermatol. 2010; 163(4): 672-82. https://dx.doi.org/10.1111/j.1365-2133.2010.09997.x.
- Федеральные клинические рекомендации. Дерматовенерология 2015: Болезни кожи. Инфекции, передаваемые половым путем. 5-е изд. М.:Деловой экспресс; 2016. 768 с. [Federal clinical guidelines. Dermatovenerology 2015: Diseases of the skin. Sexually transmitted infections. 5th edition revised and supplemented. Moscow: Business express; 2016. 768 p.(in Russian)].
- Nischal U., Nischal K.C., Khopkar U. Techniques of skin biopsy and practical consideratio Techniques of skin biopsy and practical considerations.ns. J. Cutan. Aesthet. Surg. 2008; 1(2): 107-11. https://dx.doi.org/10.4103/0974-2077.44174.
- Bleeker M.C., Visser P.J., Overbeek L.I., Beurden M.V., Berkhof J. Lichen sclerosus: incidence and risk of vulvar squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev. 2016; 25(8): 1224-30. https://dx.doi.org/10.1158/1055-9965.EPI-16-0019.
- Regauer S., Liegl B., Reich O. Early vulvar lichen sclerosus: a histopathological challenge. Histopathology, 2005; 47(4): 340-7. https://dx.doi.org/10.1111/j.1365-2559.2005.02209.x.
Received 10.04.2020
Accepted 03.06.2020
About the Authors
Inna A. Apolikhina, MD, professor, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov, Moscow, Russian Federation, First Moscow State Medical University named after I.M. Sechenov, Moscow, Russian Federation. Tel.: +7(985)410-08-11. E-mail: i_apolikhina@oparina4.ru.4, Oparina str., Moscow, 117997, Russian Federation.
Anastasia V. Sokolova, postgraduate student, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov, Moscow, Russian Federation. Tel.: +7(915)455-31-32. E-mail: a_sokolova@oparina4.ru. 4, Oparina str., Moscow, 117997, Russian Federation.
Ayna K. Musaeva, MD, obstetrician&gynecologist Aleksandro-Mariinsky Regional Clinical Hospital, Astrakhan, Russian Federation.
2, Tatischev str., Astrakhan, Russian Federation.
Nikon V. Zaitsev, MD, pathologist doctor, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov, Moscow, Russian Federation. 4, Oparina str., Moscow, 117997, Russian Federation.
For citation: Apolikhina I.A., Sokolova A.V., Musaeva A.K., Zaitsev N.V. Minimally invasive diagnosis of vulvar disease using punch biopsy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 8: 141-148 (in Russian).
https://dx.doi.org/10.18565/aig.2020.8.141-148
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