Treatment for breast cancer during pregnancy
Background: The relevance of treating patients diagnosed with breast cancer during pregnancy is indisputable. In recent years, the number of patients has become larger due to increases in the age of pregnant women and in the number of IVF procedures.Rasskazova E.A., Zikiryakhodzhaev A.D., Kaprin A.D.
Case report: The paper describes an observation of a 24-year-old patient at diagnosis; the follow-up of the patient and her child lasted 6 years. The patient received combination chemotherapy cycles during pregnancy, which were followed by delivery, continuation of drug therapy involving chemotherapy and targeted therapy cycles and by surgical treatment. The patient having a VRCA1 gene mutation underwent preventive subcutaneous mastectomy with simultaneous reconstruction for mutation carriage; thus, bilateral breast reconstruction surgery that is a method of surgical rehabilitation was performed.
Conclusion: An ultrasound study of the breasts is a mandatory diagnostic technique during pregnancy; if any breast nodule is present, its morphological verification is needed.
Keywords
breast cancer
pregnancy
subcutaneous mastectomy
preventive subcutaneous mastectomy
combination treatment
References
- Параконная А.А. Рак молочной железы и беременность. В кн.: Параконная А.А., ред. Рак и репродукция. М.: Общество онкологов-химиотерапевтов; 2011: 40-5. [Parokonnaya A.A. Breast cancer and pregnancy. Cancer and reproduction. М.; 2011: 40-5. (in Russian)].
- Снежко О.А. Рак молочной железы и беременность. Главный врач Юга России. 2018; 4: 49-51. [Snezhko O.A. Breast cancer and pregnancy. Chief Physician of the South of Russia. 2018; 4: 49-51. (in Russian)].
- Дашян Г.А., Семиглазов В.Ф., Семиглазов В.В., Топузов Э.Э., Криворотько П.В., Донских Р.В., Табагуа Т.Т, Гречухина И.А., Джукаева Ц.С. Диагностика и лечение рака молочной железы, развившегося на фоне беременности. Вопросы онкологии. 2011; 57(5): 584-91. [Dashyan G.A., Semiglazov V.F., Semiglazov V.V., Topuzov E.E., Krivorotko P.V., Donskikh R.V., Tabagua T.T, Grechukhina I.A., Dzhukaeva Sc.S. Diagnosis and treatment of breast cancer that developed on the background of pregnancy. Questions of Oncology. 2011; 57(5): 584-91. (in Russian)].
- Волочаева М.В., Шмаков Р.Г., Зубков В.В. Здоровье детей, рожденных женщинами с раком молочной железы, связанным с беременностью. Акушерство и гинекология. 2014; 7: 33-7. [Volochaeva M.V., Shmakov R.G., Zubkov V.V. Health of children born to women with breast cancer associated with pregnancy. Obstetrics and Gynecology. 2014; 7: 33-7. (in Russian)].
- Тер-Ованесов М.Д., Шаль Е.П., Кукош М.Ю., Оганисян А.Н. Рак молочной железы, ассоциированный с беременностью: диагностика, лечение, прогноз. Медицинский алфавит. 2018; 29: 10-6. [Ter-Ovanesov M.D., Shal E.P., Kukosh M.Yu., Oganisyan A.N. Breast cancer associated with pregnancy: diagnosis, treatment, prognosis. Medical Alphabet. 2018; 29: 10-6. (in Russian)].
- Azim H.A. Jr., Santoro L., Russell-Edu W., Pentheroudakis G., Pavlidis N., Peccatori F.A. Prognosis of pregnancy-associated breast cancer: a meta-analyses of 30 studies. Cancer Treat. Rev. 2012; 38(7): 834-42. https://dx.doi.org/10.1016/j.ctrv.2012.06.004.
Received 02.07.2021
Accepted 02.08.2021
About the Authors
Elena A. Rasskazova, PhD, Researcher of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin, P.A. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, rasskaz2@yandex.ru,125284, Russia, Moscow, 2nd Botkinsky passage, 3.
Aziz D. Zikiryakhodzhayev, Dr. Med. Sci., Head of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin, P.A. Hertsen Moscow
Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, azizz@mail.ru,
125284, Russia, Moscow, 2nd Botkinsky passage, 3.
Andrey D. Kaprin, Dr. Med. Sci., Professor, Academician of RAS, Academician of RAE, Honored Doctor of the Russian Federation, CEO, National Medical Research Radiological Centre, Ministry of Health of the Russian Federation; Director, P.A. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre; Head of the Department of Urology and Operative Nephrology with the Course of Oncourology, Faculty of Medicine, RUDN University;
Chief freelance oncologist of the Ministry of Health of Russia, 125284, Russia, Moscow, 2nd Botkinsky passage, 3.
Authors' contributions: Rasskazova E.A. – writing the text; search for literary sources; A.D. Zikiryakhodzhaev A.D. – writing the text; material analysis; A.D. Kaprin A.D. – editing the article.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
Patient Consent for Publication: The patient provided informed consent for the publication of her data and associated images.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Rasskazova E.A., Zikiryakhodzhaev A.D., Kaprin A.D.
Treatment for breast cancer during pregnancy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 10: 174-178 (in Russian)
https://dx.doi.org/10.18565/aig.2021.10.174-178
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