Human umbilical cord tissue cryopreservation: prospects for clinical application

Strokova S.O., Arutyunyan I.V., Mullabaeva S.M., Fatkhudinov T.Kh.

1 Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow; 2 Peoples’ Friendship University of Russia, Moscow; 3 Research Institute of Human Morphology, Moscow, Russia
The paper analyzes the data available in the modern scientific literature on the possibility of human umbilical cord tissue cryopreservation and its further clinical application. It describes protocols to obtain various biomedical products (vascular matrix, Wharton jelly-based grafts, and multipotent stromal cells) from the frozen umbilical cord, as well as prospects of their clinical use. The analysis of the literature data may be indicative of the active development of a promising cell biotechnology area, such as human umbilical cord cryopreservation.


umbilical cord
cryopreservation protocol
multipotent stromal cells


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Received 22.02.2018

Accepted 02.03.2018

About the Authors

Strokova, Svetlana O., doctor of the clinical laboratory diagnostics laboratory for the collection and storage of biomaterials, National Medical Research Center of Obstetrcis, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79169284961. E-mail: ORCID iD 0000-0002-2679-4991
Arutyunyan, Irina V., PhD, senior researcher, Laboratory of Regenerative Medicine, National Medical Research Center of Obstetrcis, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health Russia. Senior researcher, Research Institute of Human Morphology.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79261474430. E-mail: ORCID iD 0000-0002-4344-8943.
Mullabaeva, Svetlana M., head of the laboratory for the Collection and Storage of Biomaterials, National Medical Research Center of Obstetrcis, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79153220879. Е-mail:
Fatkhudinov, Timur Kh., MD, head of the Laboratory of Regenerative Medicine, National Medical Research Center of Obstetrcis, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health Russia. Professor of the Department of Histology, Cytology and Embryology, Medical Institute, Peoples’ Friendship University of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79032561157. E-mail: ORCID iD 0000-0002-6498-5764.

For citations: Strokova S.O., Arutyunyan I.V., Mullabaeva S.M., Fatkhudinov T.Kh. Human umbilical cord tissue cryopreservation: prospects for clinical application. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (12): 5-10. (in Russian)

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