Cognitive development and neuropsychic health of children conceived by assisted reproductive technologies

Lokshin V.N., Ilmuratova S.Kh.

PERSONA International Clinical Center for Reproductology, Almaty, Kazakhstan
Objective: To carry out a systematic analysis of current publications on the assessment of a risk for neuropsychiatric disorders in children conceived by assisted reproductive technologies (ART).
Materials and methods: This review includes an analysis of foreign articles found in the online databases Medline, PubMed, and Springer and published in the past 5 years.
Results: Despite the encouraging results of studies on the long-term potential consequences of ART on the neuropsychiatric health of children, information is limited due to the presence of independent risk factors for nervous system diseases that are directly unrelated to reproductive technologies, such as multiple pregnancies, preterm birth, and no comparison group of children conceived spontaneously and born to mothers with a history of infertility.
Conclusion: Considering the pace of development and introduction of up-to-date technologies in reproductology, it is necessary to further investigate the potential impact of ART on neuropsychiatric health, taking into account amendments for an adequate risk assessment. Neonatal nervous system diseases are probably more associated with multiple pregnancies and abnormal pregnancy and childbirth.


cognitive development
neurological disorders
nervous system diseases
attention deficit/hyperactivity disorder
autism spectrum disorders
cerebral palsy


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Received 26.07.2022

Accepted 01.09.2022

About the Authors

Vyacheslav N. Lokshin, Dr. Med. Sci., Professor, member of National Academy of Science Republic of Kazakhstan, President of Kazakhstan Association of the Reproductive Medicine, managing director of the PERSONA International Clinical Center for Reproductology, +7(727)382-77-77,,, 050000, Kazakhstan, Almaty, Utepova str., 32a.
Sevara Kh. Ilmuratova, pediatrician, Ph.D. candidate KSPH, PERSONA International Clinical Center for Reproductology, +7(777)801-73-05,,, 050000, Kazakhstan, Almaty, Utepova str., 32a.
Corresponding author: Sevara Kh. Ilmuratova,

Authors’ contributions: Lokshin V.N. – the concept and design of the investigation; Ilmuratova S.Kh. – material collection and processing; Lokshin V.N., Ilmuratova S.Kh. – writing the text.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: This study was conducted within the framework of the scientific and engineering project ИРН AP14872103 "Somatic and psychosocial status of children after ART determination with the development of prediction model and principles of child management" (Targeted Financing from the Ministry of Healthcare of the Republic of Kazakhstan).
For citation: Lokshin V.N., Ilmuratova S.Kh. Cognitive development and neuropsychic health of children conceived by assisted reproductive technologies.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 11: 31-36 (in Russian)

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