Live birth after using assisted reproductive technologies in a late reproductive-aged female patient with her own oocytes without preimplantation genetic testing for aneuploidies

Khachatryan L.V., Smolnikova V.Yu., Makarova N.P.

1) V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
Background: The present-day social conditions set new trends in changing the age model of birth rates with the implementation of reproductive function at a later stage, which creates a number of medical and social problems. проблем. Late reproductive aged women the most frequently face failures in the treatment of infertility by assisted reproductive technologies (ART). In addition, the women of this age cohort have high rates of pregnancy complications and perinatal morbidity.
Case report: The paper describes a clinical case of a favorable outcome of infertility treatment by ART methods using the standard short protocol with gonadotropin-releasing antagonists in a married couple of late reproductive age (the wife is 44 years; the husband is 58 years).
Conclusion: This case shows the possibility of achieving clinical pregnancy with the birth of a healthy baby in even female patients of late reproductive age, which emphasizes the need to optimize ovulation stimulation protocols and to choose the most appropriate method of infertility treatment for each married couple individually. At the same time, it is necessary to provide these married couples with information about the extremely low chances of clinical pregnancy and live birth in the treatment of infertility with ART methods and their own oocytes, as well as about the fertility preservation opportunities, including those using deferred motherhood at an earlier reproductive age.

Authors' contributions: Khachatryan L.V., Smolnikova V. Yu., Makarova N.P. – development of the concept of the investigation, search, review, and analysis of publications on the topic of the article, writing the text of the article.
Conflicts of interest: The authors declare that there are no conflicts of interests.
Funding: The investigation has not been sponsored.
Patient Consent for Publication: The patients have signed an informed consent form to the publication of their data.
For citation: Khachatryan L.V., Smolnikova V.Yu., Makarova N.P. Live birth after using assisted reproductive technologies in a late reproductive-aged female patient with
her own oocytes without preimplantation genetic testing for aneuploidies.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (7): 175-179 (in Russian)


assisted reproductive technologies (ART)
optimization of ART programs
in vitro fertilization (IVF)
late reproductive age
clinical case


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Received 01.03.2023

Accepted 28.06.2023

About the Authors

Leah V. Khachatryan, postgraduate student of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Faculty of Postgraduate Professional Training
of Physicians, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), +7(963)977-88-94,,, 119991, Russia, Moscow, Trubetskaya str., 8-2.
Veronika Yu. Smolnikova, Dr. Med. Sci., Leading Researcher, Professor B.V. Leonov Department of Assistive Technologies in Infertility Treatment, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,,
117997, Russia, Moscow, Ac. Oparin str., 4.
Natalya P. Makarova, PhD, Leading Researcher, Professor B.V. Leonov Department of Assistive Technologies in Infertility Treatment, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,,, 117997, Russia, Moscow, Ac. Oparin str., 4.

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