Hormone-dependent diseases of the pelvic organs in women over 35 years of age
Subanova G.A., Subanova N.A., Askerov A.A., Yrysbaev E.Y., Dzhumaeva L.M., Yrysbaev A.Y.
Objective: To study the structure and frequency of hormone-dependent diseases in women over 35 years of age who underwent treatment in Gynecology Department of Osh Interregional Clinical Hospital in the period 2011–2015.
Materials and methods: This was a retrospective analysis of 199 case histories of patients over 35 years of age who were treated in Gynecology Department of Osh Interregional Clinical Hospital in 2011–2015. The methods of clinical examination, ultrasound and histological examinations were used. Digital data processing was carried out in MS Excel version 16.94 using arithmetic mean calculations.
Results: The most common gynecological diseases were uterine fibroids (26.5%) and endometrial hyperplasia (25%). Ovarian torsion (17.5%), endometriosis (6.5%) and endometrial polyps (10.5%) were also diagnosed. Abnormal uterine bleeding (25%) and dysfunctional bleeding (8.5%) were more frequent among the complications. Anemia (59.5%), genital tract infections (49.5%), cystitis (35.5%) and obesity (35%) were the most common among concomitant diseases. The most frequent surgical procedures were vacuum aspiration (20%), hysterectomy (18.5%) and cystectomy (17.5%). Significant differences in the prevalence of certain diseases between urban and rural women have been identified.
Conclusion: A retrospective study of the case histories of 199 women over 35 years of age who were treated in Gynecology Department of Osh Interregional Clinical Hospital in the period 2011-2015 showed that hormone-dependent gynecological diseases, uterine bleeding and concomitant general somatic diseases are common, and surgical treatment remains relevant.
Authors’ contributions: Subanova N.A., Askerov A.A. – developing the concept and design of the study; Subanova G.A., Dzhumaeva L.M. – collecting and processing the material; Yrysbaev E.Y. – processing statistical data, editing the article; Yrysbaev A.Y. – writing the text.
Conflicts of interest: Authors declare lack of the possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Committee on Biomedical Ethics of the International Medical Faculty, Osh State University on February 02, 2025.
Patient Consent for Publication: The patients signed informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Subanova G.A., Subanova N.A., Askerov A.A., Yrysbaev E.Y., Dzhumaeva L.M., Yrysbaev A.Y.
Hormone-dependent diseases of the pelvic organs in women over 35 years of age.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (6): 149-154 (in Russian)
https://dx.doi.org/10.18565/aig.2025.56
Keywords
endometrial hyperplasia
uterine fibroids
ovarian torsion
vacuum aspiration
hysterectomy
cystectomy
References
- Chauhan S., More A., Chauhan V., Kathane A. Endometriosis: a review of clinical diagnosis, treatment, and pathogenesis. Cureus. 2022; 14(9): e28864. https://dx.doi.org/10.7759/cureus.28864
- Taylor H.S., Kotlyar A.M., Flores V.A. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet. 2021; 397(10276): 839-52. https://dx.doi.org/10.1016/S0140-6736(21)00389-5
- Saunders P.T.K., Horne A.W. Endometriosis: Etiology, pathobiology, and therapeutic prospects. Cell. 2021; 184(11): 2807-24. https://dx.doi.org/10.1016/j.cell.2021.04.041
- Allaire C., Bedaiwy M.A., Yong P.J. Diagnosis and management of endometriosis. CMAJ. 2023; 195(10): E363-E371. https://dx.doi.org/10.1503/cmaj.220637
- Базарбаева Д.А., Юсупова М.А. Современные методы диагностики и лечения миомы матки у женщин репродуктивного возраста. Вестник науки и образования. 2019; (22(76)-3): 56-9. [Bazarbayeva D.A., Yusupova M.A. Modern methods of diagnosis and treatment of uterine fibroid in women of reproductive age. Herald of Science and Education. 2019; (22 (76)-3): 56-9. (in Russian)].
- Luo S., Zhang X., Liu Z., Wang C., Pei J., Yu Y. et al. Low-dose aspirin for the prevention of preeclampsia in women with polycystic ovary syndrome: a retrospective cohort study. BMC Pregnancy Childbirth. 2025; 25(1): 98. https://dx.doi.org/10.1186/s12884-025-07183-1
- Deswal R., Narwal V., Dang A., Pundir C.S. The prevalence of polycystic ovary syndrome: a brief systematic review. J. Hum. Reprod. Sci. 2020; 13(4): 261-71. https://dx.doi.org/10.4103/jhrs.JHRS_95_18
- Sadeghi H.M., Adeli I., Calina D., Docea A.O., Mousavi T., Daniali M. et al. Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing. Int. J. Mol. Sci. 2022; 23(2): 583. https://dx.doi.org/10.3390/ijms23020583
- Оразов М.Р., Михалева Л.М., Муллина И.А. Гиперплазия эндометрия: современный взгляд на проблему. Акушерство и гинекология: новости, мнения, обучение. 2022; 10(3): 62-7. [Orazov M.R., Mikhaleva L.M., Mullina I.A. Endometrial hyperplasia: a modern view of the problem. Obstetrics and Gynecology: News, Opinions, Training. 2022; 10(3): 62-7. (in Russian)]. https://dx.doi.org/10.33029/2303-9698-2022-10-3-62-67
- Думановская М.Р., Чернуха Г.Е., Асатурова А.В., Коган Е.А. Частота выявления и структура гиперплазии эндометрия в различные возрастные периоды. Акушерство и гинекология. 2015; 3: 40-4. [Dumanovskaya M.R., Chernukha G.E., Asaturova A.V., Kogan E.A. The detection rate and pattern of endometrial hyperplasia in different age periods. Obstetrics and Gynecology. 2015; (3): 40-4 (in Russian)].
- Чернуха Г.Е., Ильина Л.М., Иванов И.А. Аномальные маточные кровотечения: ставим диагноз и выбираем лечение. Гинекология. 2018; 20(4): 4-8. [Chernukha G.E., Ilina L.M., Ivanov I.A. Abnormal uterine bleeding: we diagnose and choose treatment. Gynecology. 2018; 20(4): 4-8. (in Russian)]. https://dx.doi.org/10.26442/2079-5696_2018.4.4-8
- Чернуха Г.Е., Иванов И.А., Эфендиева З.Н., Думановская М.Р., Асатурова А.В. Этиологическая структура и возможности диагностики аномального маточного кровотечения. Гинекология. 2018; 20(2): 14-8. [Chernukha G.E., Ivanov I.A., Efendieva Z.N., Dumanovskaya M.R., Asaturova A.V. Etiological structure and diagnosis of abnormal uterine bleeding. Gynecology. 2018; 20(2): 14-8 (in Russian)]. https://dx.doi.org/10.26442/2079-5696_2018.2.14-18
- Икаев З.Э., Таймазова А.С. Дисфункциональные маточные кровотечения репродуктивного периода. Вестник науки. 2020; 3(7 (28)): 94-8. [Ikaev Z.E., Taymazova A.S. Dysfunctional uterine bleeding of the reproductive period. Vestnik nauki. 2020; 3(7 (28)): 94-8. (in Russian)].
- Zhang N., Liang Y., Meng Y.Q., Li Y.C., Lu X., Li L. et al. Analysis and identification of potential biomarkers for dysfunctional uterine bleeding. J. Reprod. Immunol. 2025; 168: 104427. https://dx.doi.org/10.1016/j.jri.2025.104427
- Jejaw M., Demissie K.A., Tiruneh M.G., Abera K.M., Tsega Y., Endawkie A. et al. Prevalence and determinants of unintended pregnancy among rural reproductive age women in Ethiopia. Sci. Rep. 2025; 15(1): 860. https://dx.doi.org/10.1038/s41598-024-81067-w
- Pregnancy at age 35 years or older: ACOG Obstetric Care Consensus No. 11. Obstet. Gynecol. 2022; 140(2): 348-66. https://dx.doi.org/10.1097/AOG.0000000000004873
- Teferi H.M., Schröders J. Contributing factors for urban-rural inequalities in unmet need for family planning among reproductive-aged women in Ethiopia: a Blinder-Oaxaca decomposition analysis. BMC Women's Health. 2023; 23: 158. https://dx.doi.org/10.1186/s12905-023-02304-4
- Арутюнова Е.Э., Каткова А.С., Буралкина Н.А. Этногеография миомы матки: эпидемиология, возрастные и расовые различия, виды оперативных вмешательств. Consilium Medicum. 2018; 20(6): 26-30. [Arutyunova E.E., Katkova A.S., Buralkina N.A. Ethnogeography of uterine fibroids: epidemiology, age and race differences, types of surgery. Consilium Medicum. 2018; 20(6): 26-30. (in Russian)]. https://dx.doi.org/10.26442/2075-1753_2018.6.26-30
- GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390(10100): 1211-59. https://dx.doi.org/10.1016/S0140-6736(17)32154-2
- Тихончук Е.Ю., Асатурова А.В., Адамян Л.В. Частота выявления и структура патологических изменений эндометрия у женщин репродуктивного возраста с генитальным эндометриозом. Акушерство и гинекология. 2016; 12: 87-95. [Tikhonchuk E.Yu., Asaturova A.V., Adamyan L.V. The detection rate and the structure of pathological changes of the endometrium in women of reproductive age with endometriosis. Obstetrics and Gynecology. 2016; (12): 87-95. (in Russian)]. https://dx.doi.org/10.18565/aig.2016.12.87-95
- Bradley L.D., Gueye N.A. The medical management of abnormal uterine bleeding in reproductive-aged women. Am. J. Obstet. Gynecol. 2016; 214(1): 31-44. https://dx.doi.org/10.1016/j.ajog.2015.07.044
- Victora C.G., Christian P., Vidaletti L.P., Gatica-Domínguez G., Menon P., Black R.E. Revisiting maternal and child undernutrition in low-income and middle-income countries: variable progress towards an unfinished agenda. Lancet. 2021; 397(10282): 1388-99. https://dx.doi.org/10.1016/S0140-6736(21)00394-9
- Stephenson J., Heslehurst N., Hall J., Schoenaker D.A.J.M., Hutchinson J., Cade J.E. et al. Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. Lancet. 2018; 391(10132): 1830-41. https://dx.doi.org/10.1016/S0140-6736(18)30311-8
- Villar J., Ariff S., Gunier R.B., Thiruvengadam R., Rauch S., Kholin A. et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA Pediatr. 2021; 175(8): 817-26. https://dx.doi.org/10.1001/jamapediatrics.2021.1050
- Крутиков Е.С., Шурыгина О.Ю., Сорокина Л.Е., Гордиенко А.И., Малый К.Д. Генетические маркеры нарушений иммунного ответа у женщин репродуктивного возраста с острым пиелонефритом. Нефрология. 2018; 22(5): 39-44. [Krutikov E.S., Shurigina O.Yu., Sorokina L.E., Gordiyenko A.I., Malyj K.D. Genetic markers of immune response disorders in women of reproductive age with acute pyelonephritis. Nephrology (Saint-Petersburg). 2018; 22(5): 39-44 (in Russian)]. https://dx.doi.org/10.24884/1561-6274-2018-22-5-39-44
- Hu K.L., Zhao J., Lin M., Wang X., Qi L., Liu H. et al. Addition of operative hysteroscopy to vacuum aspiration for the management of early pregnancy loss after in vitro fertilization. Fertil. Steril. 2024; 122(6): 1134-43. https://dx.doi.org/10.1016/j.fertnstert.2024.07.027
Received 28.02.2025
Accepted 22.05.2025
About the Authors
Guljamal A. Subanova, PhD, Associate Professor at the Department of Clinical Disciplines 2, International Medical Faculty, Osh State University,Kyrgyzstan, Osh city, Abiya Kabylova str., 215/2, 2nd building, +996(772) 23-05-19 gsubanova@oshsu.kg, https://orcid.org/0000-0003-1003-678X
Nargiza A. Subanova, Teaching Assistant at the Department of Obstetrics and Gynecology No. 2, Kyrgyz State Medical Academy named after I.K. Akhunbayev,
720020 Kyrgyzstan, Bishkek, Isa Akhunbayeva str., 92, +996(507)50-55-05, nargiza.subanova@bk.ru , https://orcid.org/0000-0003-1455-7902
Arsen A. Askerov, Dr. Med. Sci., Associate Professor, Head of the Department of Clinical Disciplines, Bishkek International Medical Institute,
720065, Kyrgyzstan, Bishkek, Shabdan Baatyr Ave., 4a, +996(550)33-17-31, askerov.arsen@inbox.ru, https://orcid.org/0000-0003-4447-9650
Erzamat Y. Yrysbaev, Lecturer at the Department of General, Clinical Biochemistry and Pathophysiology, Faculty of Medicine, Osh State University,
Kyrgyzstan, Osh city, Abiya Kabylova str., 215/2, 1st building, +996(706)82-03-50, yrysbaev@oshsu.kg , https://orcid.org/0000-0003-0476-2654
Lazokathan M. Dzhumaeva, PhD, Senior Lecturer, International Medical Faculty, Osh State University, Kyrgyzstan, Osh city, Abiya Kabylova str., 215/2, 2nd building, +996(772)33-64-33, ldjumaeva@oshsu.kg, https://orcid.org/0000-0002-5465-2528
Azamat Y. Yrysbayev, Lecturer at the Department of Therapeutic Disciplines, Higher School of Medicine, Salymbekov University,
720080, Kyrgyzstan, Bishkek, Julius Fuchik str., 3, +996(704)24-52-96, yrysbaev1996@gmail.com, https://orcid.org/0009-0009-4978-994X
Corresponding author: Erzamat Y. Yrysbaev, yrysbaev@oshsu.kg
Similar Articles
