Risk factors for uterine fibroids: a bibliometric analysis
Babaeva N.I., Atalyan A.V., Dmitriev V.Ya., Suturina L.V.
Uterine fibroids are benign monoclonal tumors that arise from smooth muscle cells of the myometrium. The studies currently focus on the risk factors for the development of uterine fibroids. Scientists are well aware of non-modifiable risk factors such as race, age of menarche, etc.; however, manageable risk factors are still poorly understood.
Objective: To classify the literature data on the search and assessment of the risk factors for uterine fibroids.
Materials and methods: A search was conducted for the sources published between 2013 and February 2024, represented in the PubMed database, and containing keywords that matched the search strategy. The bibliometric analysis was performed using software R (version R-4.3.2), RStudio (version 2023.09.1+494), and Bibliometrix library for R (version 4.1.3).
Results: The bibliometric analysis identified 23 articles that met the study parameters: 7 systematic reviews and meta-analyses, 15 literature reviews, and 1 article with the data of the randomized Mendeleev study. There is an increase in the number of publications starting from 2021. The West China Second Hospital and Shiraz University of Medical Sciences are the most frequent publishers of articles on this issue. Ciebiera M. is the most commonly cited author who studies risk factors for uterine fibroids.
Conclusion: The bibliometric analysis showed the main trends in the study of the risk factors for uterine fibroids. It also demonstrated the need for further retrospective, prospective and other types of research to identify modifiable risk factors for uterine fibroids for the prediction and prevention of their development.
Authors’ contributions: Babaeva N.I. – defining the search strategy, writing the article; Atalyan A.V. – methodology of bibliometric analysis, editing the article; Dmitriev V.Ya. – conducting bibliometric research, visualization of research results; Suturina L.V. – developing the concept, general supervision, editing the text of the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was performed within the framework of the state assign-ments: “Pathophysiological mechanisms and genetic and metabolic predictors of reproductive health and longevity in different age, gender and ethnic groups” (No. 121022500180-6) and “Prediction of metabolic and psycho-emotional dis-orders in women of different age groups with hyperandrogenic disorders for the development of personalized approaches to prevention and treatment” (No. 1022040800022-7-3.2.2.2.:3.2.24).
For citation: Babaeva N.I., Atalyan A.V., Dmitriev V.Ya., Suturina L.V. Risk factors for uterine fibroids: a bibliometric analysis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (7): 145-149 (in Russian)
https://dx.doi.org/10.18565/aig.2024.57
Keywords
uterine fibroids
leiomyoma
prognostic factors
risk factors
predictors
diet
smoking
alcohol
obesity
bibliometric analysis
References
- Kubik-Huch R.A., Weston M., Nougaret S., Leonhardt H., Thomassin-Naggara I., Horta M. et al. European Society of Urogenital Radiology (ESUR) guidelines: MR imaging of leiomyomas. Eur. Radiol. 2018; 28(8): 3125-37. https://dx.doi.org/10.1007/s00330-017-5157-5.
- Stewart E.A., Cookson C.L., Gandolfo R.A., Schulze-Rath R. Epidemiology of uterine fibroids: a systematic review. BJOG. 2017; 124(10): 1501-12. https://dx.doi.org/1010.1111/1471-0528.14640.
- Адамян Л.В. Миома матки: диагностика, лечение и реабилитация. Клинические рекомендации (протокол). М., 2015. [Adamyan L.V. Uterine fibroids: diagnosis, treatment and rehabilitation. Clinical guidelines (protocol). Moscow; 2015. (in Russian)].
- Whiteman M.K., Kuklina E., Jamieson D.J., Hillis S.D., Marchbanks P.A. Inpatient hospitalization for gynecologic disorders in the United States. Am. J. Obstet. Gynecol. 2010; 202(6): 541.e1-6. https://dx.doi.org/10.1016/j.ajog.2009.12.013.
- Atalyan A.V., Suturina L.V., Nadeliaeva I.G., Lazareva L.M., Shari-fulin E.M.,Danusevich I.N. Prevalence of uterine fibroids in women in Eastern Siberia: a cross-sectional study. Int. J. Biomed. 2021; 11(4): 515-8. https://dx.doi.org/10.21103/Article11(4)_OA18.
- Daniels J., Middleton L.J., Cheed V., McKinnon W., Rana D., Sirkeci F. et al. Uterine artery embolisation versus myomectomy for premenopausal women with uterine fibroids wishing to avoid hysterectomy: the FEMME RCT. Health Technol. Assess. 2022; 26(22): 1-74. https://dx.doi.org/10.3310/ZDEG6110.
- Wise L.A., Laughlin-Tommaso S.K. Epidemiology of uterine fibroids: from menarche to menopause. Clin. Obstet. Gynecol. 2016; 59(1): 2-24. https://dx.doi.org/10.1097/GRF.0000000000000164.
- Yu O., Scholes D., Schulze-Rath R., Grafton J., Hansen K., Reed S.D. A US population-based study of uterine fibroid diagnosis incidence, trends, and prevalence: 2005 through 2014. Am. J. Obstet. Gynecol. 2018; 219(6):591.e1-591.e8. https://dx.doi.org/10.1016/j.ajog.2018.09.039.
- Paffoni A., Somigliana E., Vigano' P., Benaglia L., Cardellicchio L., Pagliardini L. et al. Vitamin D status in women with uterine leiomyomas. J. Clin. Endocrinol. Metab. 2013; 98(8): E1374-8. https://dx.doi.org/10.1210/jc.2013-1777.
- Wise L.A., Palmer J.R., Harlow B.L., Spiegelman D., Stewart E.A., Adams-Campbell L.L. et al. Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study. Hum. Reprod. 2004; 19(8): 1746-54. https://dx.doi.org/10.1093/humrep/deh309.
- He Y., Zeng Q., Dong S., Qin L., Li G., Wang P. Associations between uterine fibroids and lifestyles including diet, physical activity and stress: a case-control study in China. Asia Pac. J. Clin. Nutr. 2013; 22(1): 109-17. https://dx.doi.org/10.6133/apjcn.2013.22.1.07.
- Keizer A.L., Semmler A., Kok H.S., van Kesteren P.J M., Huirne J.A.F., Hehenkamp W.J.K. Modifiable prognostic factors in uterine fibroid development: a systematic review of literature. J. Obstet. Gynaecol. 2024; 44(1): 2288225. https://dx.doi.org/10.1080/01443615.2023.2288225.
- Takala H., Yang Q., El Razek A.M.A., Ali M., Al-Hendy A. Alcohol consumption and risk of uterine fibroids. Curr. Mol. Med. 2020; 20(4): 247-58. https://dx.doi.org/10.2174/1566524019666191014170912.
- Цыренов Т.Б., Даржаев З.Ю., Сутурина Л.В., Лабыгина А.В., Павлова В.П., Ринчиндоржиева М.П., Шипхинеева Т.И. Гормонозависимые гинекологические заболевания у бесплодных женщин основных этнических групп Республики Бурятия. Бюллетень ВСНЦ СО РАМН. 2013; 4(92): 74-6. [Tsyrenov Т.B., Darzhaev Z.Yu., Suturina L.V., Labygina A.V., Pavlova V.P., Rinchindorzhieva M.P., Shipkhineeva T.I. Hormone-dependent gynecological diseases in infertile women of the main ethnic groups of the Republic of Buryatia. Bulletin of ESSC SB RAMS. 2013; 4(92): 74-6. (in Russian)].
- Qu Y., Chen L., Guo S., Liu Y., Wu H. Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study. Front. Endocrinol. (Lausanne). 2023; 14: 1133260. https://dx.doi.org/10.3389/fendo.2023.1133260.
- Mu X., Du X., Yao K., Zhao J., Bian C., Wang Q. et al. Association between HSD17B1 rs605059 polymorphisms and the risk of uterine diseases: a systemic review and meta-analysis. Int. J. Clin. Exp. Pathol. 2015; 8(6): 6012-8.
- Korczynska L., Zeber-Lubecka N., Zgliczynska M., Zarychta E., Zareba K., Wojtyla C. et al. The role of microbiota in the pathophysiology of uterine fibroids - a systematic review. Front. Cell. Infect. Microbiol. 2023; 13: 1177366. https://dx.doi.org/10.3389/fcimb.2023.1177366.
- Ступко Е.Е., Шулунов С.С., Шенин В.А., Лабыгина А.В., Сутурина Л.В., Коваленко И.И. Полиморфизм генов GSTM1, GSTT1 и GSTP1 у женщин с миомой матки. Бюллетень ВСНЦ СО РАМН. 2010; 6(76) Часть 2: 63-6. [Stupko E.E., Shulunov S.S., Shenin V.A., Labygina A.V., Suturina L.V., Kovalenko I.I. Polymorphism of GSTM1, GSTT1 and GSTP1 genes in women with uterine myoma. Bulletin of ESSC SB RAMS. 2010; 6(76) Pt 2: 63-6.(in Russian)].
- Сутурина Л.В., Скляр Н.В., Лабыгина А.В., Коваленко И.И., Ильин В.П., Шолохов Л.Ф. Некоторые гормонально-метаболические маркеры нарушений репродуктивной функции у женщин с миомой матки. Доктор.Ру. 2009; 6(50): 18-21. [Suturina L.V., Sklyar N.V., Labygina A.V., Kovalenko I.I., Ilyin V.P., Sholokhov L.F. Hormonal and metabolic markers of disordered reproductive function in females with uterine myoma. Doctor.Ru. 2009; 6(50): 18-21. (in Russian)].
- Пономаренко И.В., Полоников А.В., Чурносов М.И. Полиморфные локусы гена LHCGR, ассоциированные с развитием миомы матки. Акушерство и гинекология. 2018; 10: 86-91. [Ponomarenko I.V., Polonikov A.V., Churnosov M.I. Polymorphic LHCGR gene loci associated with the development of uterine fibroids. Obstetrics and Gynecology. 2018; (10): 86-91. (in Russian)]. https://dx.doi.org/10.18565/aig.2018.10.86-91.
- Yang Q., Ciebiera M., Bariani M.V., Ali M., Elkafas H., Boyer T.G. et al. Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment. Endocr. Rev. 2022; 43(4): 678-719. https://dx.doi.org/10.1210/endrev/bnab039.
- Kumari R., Nath B., Kashika, Gaikwad H.S., Sharma M. Association between serum vitamin D level and uterine fibroid in premenopausal women in Indian population. Drug Discov. Ther. 2022; 16(1): 8-13. https://dx.doi.org/10.5582/ddt.2021.01019.
- Yang Y., He Y., Zeng Q., Li S. Association of body size and body fat distribution with uterine fibroids among Chinese women. J. Womens Health (Larchmt). 2014; 23(7): 619-26. https://dx.doi.org/10.1089/jwh.2013.4690.
- Пономаренко М.С., Решетников Е.А., Пономаренко И.В., Чурносов М.И. Факторы риска развития миомы матки. Акушерство и гинекология. 2024; 3: 20-7. [Ponomarenko M.S., Reshetnikov E.A., Ponomarenko I.V., Churnosov M.I. Risk factors for uterine fibroids. Obstetrics and Gynecology. 2024; (3): 20-7. (in Russian)]. https://dx.doi.org/10.18565/aig.2023.275.
- Ciebiera M., Włodarczyk M., Słabuszewska-Jóźwiak A. Nowicka G., Jakiel G. Influence of vitamin D and transforming growth factor β3 serum concentrations, obesity, and family history on the risk for uterine fibroids. Fertil. Steril. 2016; 106(7): 1787-92. https://dx.doi.org/10.1016/j.fertnstert.2016.09.007.
- Ciebiera M., Ali M., Prince L., Zgliczyński S., Jakiel G., Al-Hendy A. The significance of measuring vitamin D serum levels in women with uterine fibroids. Reprod. Sci. 2021; 28(8): 2098-109. https://dx.doi.org/10.1007/s43032-020-00363-8.
Received 10.07.2024
Accepted 16.07.2024
About the Authors
Natalia I Babaeva, Junior Researcher at the Laboratory of Gynecological Endocrinology, Scientific Center for Problems of Family Health and Human Reproduction,664003, Russia, Irkutsk, Timiryazeva str., 16, +7(3952)20-76-36, miracle_909@mail.ru, https://orcid.org/0000-0002-7604-6246
Alina V. Atalyan, PhD, Senior Researcher at the Laboratory of Socially Significant Problems of Reproductology, Scientific Center for Family Health Problems and Human Reproduction, 664003, Russia, Irkutsk, Timiryazev str., 16, +7(3952)20-76-36, alinaa@mail.ru, https://orcid.org/0000-0002-3407-9365
Vsevolod Ya. Dmitriev, Research Assistant at the Functional Group of Information Systems and Biostatistics, Research Center for Family Health and Human Reproduction, 664003, Russia, Irkutsk, Timiryazeva str., 16, +7(3952)20-76-36, dmitriew.vsevolod@yandex.ru, https://orcid.org/0009-0006-1945-2105
Larisa V. Suturina, Dr. Med. Sci., Professor, Head of the Department of Reproductive Health, Scientific Center for Family Health Problems and Human Reproduction,
664003, Russia, Irkutsk, Timiryazeva str., 16, +7(3952) 20-76-36, lsuturina@mail.ru, https://orcid.org/0000-0002-6271-780
Corresponding author: Natalia I. Babaeva, miracle_909@mail.ru
Similar Articles
