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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2024№7
Novel concepts in the pathogenesis...

Novel concepts in the pathogenesis and risk factors of endometriosis

DOI
https://dx.doi.org/10.18565/aig.2024.110

Ponomareva T.A., Altukhova O.B., Ponomarenko I.V., Churnosov M.I.

1) St. Joasaph Belgorod Regional Clinical Hospital, Belgorod, Russia; 2) Belgorod State National Research University, Belgorod, Russia

Endometriosis is one of the most important gynecological diseases in terms of medical, social and economic importance. Along with uterine fibroids and pelvic inflammatory diseases, endometriosis is one of the three most common gynecologic diseases in the Russian Federation. A review of the literature reveals that the risk of endometriosis development is associated with various factors such as early menarche, heavy and prolonged menstrual bleeding, short menstrual cycle, low parity, operative delivery in the history, low body mass index, sexual activity during menstruation, decreased physical activity, pelvic inflammatory diseases, uterine anomalies, exposure to environmental factors, smoking, excessive consumption of alcohol, coffee, red meat, low vitamin D levels, polymorphism of candidate genes. Various anatomical, hormonal, immunologic, environmental, and genetic factors are involved in the pathogenesis of endometriosis.
Conclusion: Despite the large amount of research that has been conducted, the ultimate causes of endometriosis are still unknown. The mechanisms of endometrioid foci are the subject of numerous theories, yet endometriosis remains an enigmatic disease that demands further research.

Authors’ contributions: Ponomareva T.A. – literature search and analysis, evidence summary, writing the text of the manuscript; Ponomarenko I.V. – editing the text of the manuscript; Altukhova O.B. – developing the concept and design of the article; Churnosov M.I. – reviewing, final editing. 
Conflicts of interest: Authors declare lack of the possible conflicts of interest.
Funding: The study was conducted without sponsorship.
For citation: Ponomareva T.A., Altukhova O.B., Ponomarenko I.V., Churnosov M.I. 
Novel concepts in the pathogenesis and risk factors of endometriosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (7): 12-20 (in Russian)
https://dx.doi.org/10.18565/aig.2024.110

Keywords

endometriosis
risk factors
gynecology
pathogenesis
Full text (in Russian)

References

  1. Laganà A.S., Garzon S., Götte M., Viganò P., Franchi M., Ghezzi F. et al. The pathogenesis of endometriosis: molecular and cell biology insights. Int. J. Mol. Sci. 2019; 20(22): 5615. https://dx.doi.org/10.3390/ijms20225615.
  2. Zondervan K.T., Becker C.M., Missmer S.A. Endometriosis. N. Engl. J. Med. 2020; 382(13): 1244-56. https://dx.doi.org/10.1056/NEJMra1810764.
  3. Адамян Л.В., Арсланян К.Н., Логинова О.Н., Манукян Л.М., Харченко Э.И. Иммунологические аспекты эндометриоза: обзор литературы. Лечащий врач. 2020; 4: 37. [Adamyan L.V., Arslanyan K.N., Loginova O.N., Manukyan L.M., Kharchenko E.I. Immunological aspects of endometriosis. literature review. Lechashchii Vrach. 2020; (4): 37. (in Russian)]. https://dx.doi.org/10.26295/OS.2020.29.10.007.
  4. Andres M.P., Arcoverde F.V., Souza C.C., Fernandes L.F., Abrão M.S., Kho R.M. Extrapelvic endometriosis: A systematic review. J. Minim. Invasive Gynecol. 2020; 27(2): 373-89. https://dx.doi.org/10.1016/j.jmig.2019.10.004.
  5. Адамян Л.В., Андреева Е.Н. Редкие формы эндометриоза. Проблемы репродукции. 2022; 28(1): 45-53. [Adamyan L.V., Andreeva E.N. The rarest forms of endometriosis. Russian Journal of Human Reproduction. 2022; 28(1): 45-53. (in Russian)]. https://dx.doi.org/10.17116/repro20222801145.
  6. Пономаренко И.В., Полоников А.В., Чурносов М.И. Молекулярные механизмы и факторы риска развития эндометриоза. Акушерство и гинекология. 2019; 3: 26-31. [Ponomarenko I.V., Polonikov A.V., Churnosov M.I. Molecular mechanisms of and risk factors for endometriosis. Obstetrics and Gynecology. 2019; (3): 26-31. (in Russian)]. https://dx.doi.org/10.18565/aig.2019.3.26-31.
  7. Андреев А.Е., Клейменова Т.С., Дробинцева А.О., Полякова О.Л., Кветной И.М. Сигнальные молекулы, вовлеченные в образование новых нервных окончаний при эндометриозе (обзор). Научные результаты биомедицинских исследований. 2019; 5(1): 94-107. [Andreev A.E., Kleimenova T.S., Drobintseva A.O., Polyakova O.L., Kvetnoy I.M. Signal molecules involved in the formation of new nerve endings in endometriosis (review). Research Results in Biomedicine. 2019; 5(1): 94-107. (in Russian)]. https://dx.doi.org/10.18413/2313-8955-2019-5-1-0-7.
  8. Sampson J.A. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am. J. Obstet. Gynecol. 1927; 14:422-69. https://dx.doi.org/10.1016/s0002-9378(15)30003-x.
  9. Kapoor R., Stratopoulou C.A., Dolmans M.M. Pathogenesis of endometriosis: new insights into prospective therapies. Int. J. Mol. Sci. 2021; 22(21): 11700. https://dx.doi.org/10.3390/ijms222111700.
  10. Huang E., Wang X., Chen L. Regulated cell death in endometriosis. Biomolecules. 2024; 14(2): 142. https://dx.doi.org/10.3390/biom14020142.
  11. Tsamantioti E.S., Mahdy H. Endometriosis. StatPearls; 2023.
  12. Li J., Liu Y.D.K., Xiao L., He X., Dai F., Tang J. Endometriosis in para-aortic lymph node resembling a malignancy: a case report and literature review. BMC Womens Health. 2022; 22(1): 101. https://dx.doi.org/10.1186/s12905-022-01659-4.
  13. Monnin N., Fattet A.J., Koscinski I. Endometriosis: update of pathophysiology, (Epi) genetic and environmental involvement. Biomedicines. 2023; 11(3): 978. https://dx.doi.org/10.3390/biomedicines11030978.
  14. Головченко И.О. Генетические детерминанты уровня половых гормонов у больных эндометриозом. Научные результаты биомедицинских исследований. 2023; 9(1): 5-21. [Golovchenko I.O. Genetic determinants of sex hormone levels in endometriosis patients. Research Results in Biomedicine. 2023; 9(1): 5-21. (in Russian)]. https://dx.doi.org/10.18413/2658-6533-2023-9-1-0-1.
  15. Yilmaz B.D., Bulun S.E. Endometriosis and nuclear receptors. Hum. Reprod. Update. 2019; 25(4): 473-85. https://dx.doi.org/10.1093/humupd/dmz005.
  16. Bulun S.E., Yilmaz B.D., Sison C., Miyazaki K., Bernardi L., Liu S., Kohlmeier A. et al. Endometriosis. Endocr. Rev. 2019; 40: 1048-79. https://dx/doi.org/10.1210/er.2018-00242.
  17. Clemenza S., Capezzuoli T., Eren E., Garcia Garcia J.M., Vannuccini S., Petraglia F. Progesterone receptor ligands for the treatment of endometriosis. Minerva Obstet. Gynecol. 2023; 75(3): 288-97. https://dx.doi.org/10.23736/s2724-606x.22.05157-0.
  18. Marquardt R.M., Kim T.H., Shin J.H., Jeong J.W. Progesterone and estrogen signaling in the endometrium: What Goes Wrong in Endometriosis? Int. J. Mol. Sci. 2019; 20(15): 3822. https://dx.doi.org/10.3390/ijms20153822.
  19. Abramiuk M., Grywalska E., Małkowska P., Sierawska O., Hrynkiewicz R., Niedźwiedzka-Rystwej P. The role of the immune system in the development of endometriosis. Cells. 2022; 11(13): 2028. https://dx.doi.org/10.3390/cells11132028.
  20. Chen S., Liu Y., Zhong Z., Wei C., Liu Y., Zhu X. Peritoneal immune microenvironment of endometriosis: role and therapeutic perspectives. Front. Immunol. 2023; 14:1134663. https://dx.doi.org/10.3389/fimmu.2023.1134663.
  21. Hu L., Zhang J., Lu Y., Fu B., Hu W. Estrogen receptor beta promotes endometriosis progression by upregulating CD47 expression in ectopic endometrial stromal cells. J. Reprod. Immunol. 2022; 151: 103513. https://dx.doi.org/10.1016/j.jri.2022.103513.
  22. Григоркевич О.С., Мокров Г.В., Косова Л.Ю. Матриксные металлопротеиназы и их ингибиторы. Фармакокинетика и фармакодинамика. 2019; 2: 3-16. [Grigorkevich O.S., Mokrov G.V., Kosova L.Yu. Matrix metalloproteinases and their inhibitors. Pharmacokinetics and Pharmacodynamics. 2019; (2): 3-16. (in Russian)]. https://dx.doi.org/10.24411/2587-7836-2019-10040.
  23. Signorile P.G., Viceconte R., Baldi A. New insights in pathogenesis of endometriosis. Front. Med. (Lausanne). 2022; 9: 879015. https://dx.doi.org/10.3389/fmed.2022.879015.
  24. Freytag D., Mettler L., Maass N., Günther V., Alkatout I. Uterine anomalies and endometriosis. Minerva Med. 2020; 111(1): 33-49. https://dx.doi.org/10.23736/s0026-4806.19.06341-9.
  25. Maruyama T. A revised stem cell theory for the pathogenesis of endometriosis. J. Pers. Med. 2022; 12(2): 216. https://dx.doi.org/10.3390/jpm12020216.
  26. Фархат К.Н., Савилова А.М., Макиян З.Н., Адамян Л.В. Эндометриоз: роль стволовых клеток в развитии заболевания (обзор литературы). Проблемы репродукции. 2016; 22(1): 20-7. [Farkhat K.N., Savilova A.M., Makiian Z.N., Adamyan L.V. The role of stem cells in the pathogenesis of endometriosis (а review). Russian Journal of Human Reproduction. 2016; 22(1): 20-7.(in Russian)]. https://dx.doi.org/10.17116/repro201622120-27.
  27. Shim J.Y., Laufer M.R. Adolescent endometriosis: an update. J. Pediatr. Adolesc. Gynecol. 2020; 33(2): 112-9. https://dx.doi.org/10.1016/j.jpag.2019.11.011.
  28. Tandashvili L., Gvenetadze A., Iremadze L., Tanos V. Neonatal uterine bleeding as a precursor to endometriosis in adulthood. Afr. J. Reprod. Health. 2022; 26(8): 83-8. https://dx.doi.org/10.1186/isrctn60023255.
  29. Ogawa K., Khan K.N., Kuroboshi H., Koshiba A., Shimura K., Tajiri T. et al. Is neonatal uterine bleeding responsible for early-onset endometriosis? Reprod. Biol. Endocrinol. 2023; 21(1): 56. https://dx.doi.org/10.1186/s12958-023-01099-1.
  30. Owusu-Akyaw A., Krishnamoorthy K., Goldsmith L.T., Morelli S.S. The role of mesenchymal-epithelial transition in endometrial function. Hum. Reprod. Update. 2019; 25(1): 114-33. https://dx.doi.org/10.1093/humupd/dmy035.
  31. Украинец Р.В., Корнева Ю.С. Трансцеломическая и лимфогематогенная диссеминация эндометриоидных гетеротопий – механизм формирования экстрагенитальных форм эндометриоза. Журнал анатомии и гистопатологии. 2021; 10(1): 85-91. [Ukrainets R.V., Korneva YU.S. Transcoelomic and lymphohematogenous dissemination of edometrioid heterotopias is a mechanism for the formation of extragenital forms of endometriosis. Journal of Anatomy and Histopathology. 2021; 10(1): 85-91. (in Russian)]. https://dx.doi.org/10.18499/2225-7357-2021-10-1-85-91.
  32. Habiba M., Benagiano G., Guo S.W. An Appraisal of the Tissue Injury and Repair (TIAR) theory on the pathogenesis of endometriosis and adenomyosis. Biomolecules. 2023; 13(6): 975. https://dx.doi.org/10.3390/biom13060975.
  33. Stefansson H., Geirsson R.T., Steinthorsdottir V., Jonsson H., Manolescu A., Kong A. et al. Genetic factors contribute to the risk of developing endometriosis. Hum. Reprod. 2002; 17(3): 555-9. https://dx.doi.org/10.1093/humrep/17.3.555.
  34. Montgomery G.W. The genetics of endometriosis. Twin Res. Hum. Genet. 2020; 23(2): 103-14. https://dx.doi.org/10.1017/thg.2020.36.
  35. Пономарева Т.А., Алтухова О.Б., Пономаренко И.В., Чурносов М.И. Роль генетических факторов в формировании эндометриоидных поражений. Акушерство, гинекология и репродукция. 2023; 17(4): 443-54. [Ponomareva T.A., Altukhova O.B., Ponomarenko I.V., Churnosov M.I. The role of genetic factors in developing endometrioid lesions. Obstetrics, Gynecology and Reproduction. 2023; 17(4): 443-54. (in Russian)]. https://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2023.434.
  36. Lu R.H., Zhu J.W., Xue Q. Research progress on epigenetics in endometriosis. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2023; 45(1): 124-128.
  37. Blass I., Sahar T., Shraibman A., Ofer D., Rappoport N., Linial M. Revisiting the risk factors for endometriosis: A Machine Learning Approach. J. Pers. Med. 2022; 12(7): 1114. https://dx.doi.org/10.3390/jpm12071114.
  38. Parazzini F., Esposito G., Tozzi L., Noli S., Bianchi S. Epidemiology of endometriosis and its comorbidities. Eur. J. Obstet. Gynecol. Reprod. Biol. 2017; 209: 3-7. https://dx.doi.org/10.1016/j.ejogrb.2016.04.021.
  39. Nnoaham K.E., Webster P., Kumbang J., Kennedy S.H., Zondervan K.T. Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies. Fertil. Steril. 2012; 98(3): 702-12. https://dx.doi.org/10.1016/j.fertnstert.2012.05.035.
  40. Ashrafi M., Sadatmahalleh S.J., Akhoond M.R., Talebi M. Evaluation of risk factors associated with endometriosis in infertile women. Int. J. Fertil. Steril. 2016; 10(1): 11-21.
  41. Mollazadeh S., Mirzaii Najmabadi K., Mirghafourvand M., Latifnejad Roudsari R. Sexual activity during menstruation as a risk factor for endometriosis: A systematic review and meta-analysis. Int. J. Fertil. Steril. 2023; 17(1): 1-6. https://dx.doi.org/10.1186/s12978-021-01276-8.
  42. Aarestrup J., Jensen B.W., Ulrich L.G., Hartwell D., Trabert B., Baker J.L. Birth weight, childhood body mass index and height and risks of endometriosis and adenomyosis. Ann. Hum. Biol. 2020; 47(2): 173-180. https://dx.doi.org/10.1080/03014460.2020.1727011.
  43. Liu Y., Zhang W. Association between body mass index and endometriosis risk: a meta-analysis. Oncotarget. 2017; 8(29): 46928-36. https://dx.doi.org/10.18632/oncotarget.14916.
  44. Tang Y., Zhao M., Lin L., Gao Y., Chen G.Q., Chen S. et al. Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case-control study in China? BMJ Open. 2020; 10(9): 037095. https://dx.doi.org/10.1136/bmjopen-2020-037095.
  45. Vercellin P., Buggio L., Somigliana E., Barbara G., Vigand P., Fedele L. Attractiveness of women with rectovaginal endometriosis: a case-control study. Fertil. Steril. 2013; 99(1): 212-8. https://dx.doi.org/10.1016/j.fertnstert.2012.08.039.
  46. Wei M., Cheng Y., Bu H., Zhao Y., Zhao W. Length of menstrual cycle and risk of endometriosis: a meta-analysis of 11 case-control studies. Medicine (Baltimore). 2016; 95(9): e2922. https://dx.doi.org/10.1097/MD.0000000000002922.
  47. Critchley H.O.D., Maybin J.A., Armstrong G.M., Williams A.R.W. Physiology of the endometrium and regulation of menstruation. Physiol. Rev. 2020; 100(3): 1149-79. https://dx.doi.org/10.1152/physrev.00031.2019.
  48. Баранов В.С. Критические периоды развития эндометриоза. Экологическая генетика. 2018; 16(2): 36-9. [Baranov V.S. Sensitive periods in development of endometriosis. Ecological Genetics. 2018; 16(2): 36-9.(in Russian)]. https://dx.doi.org/10.17816/ecogen16236-39.
  49. Фархат К.Н., Адамян Л.В. Аномалии развития матки и влагалища в сочетании с эндометриозом: тактика ведения и хирургическая коррекция. Акушерство и гинекология. 2016; 5: 96-102. [Farhat K.N., Adamyan L.V. Anomalies of the uterus and vagina in combination with endometriosis: management tactics and surgical correction. Obstetrics and Gynecology. 2016; (5): 96-102. (in Russian)]. https://dx.doi.org/10.18565/aig.2016.5.96-102.
  50. Piriyev E., Römer T. Coincidence of uterine malformations and endometriosis: a clinically relevant problem? Arch. Gynecol. Obstet. 2020; 302(5): 1237-41. https://dx.doi.org/10.1007/s00404-020-05750-9.
  51. Freytag D., Mettler L., Maass N., Günther V., Alkatout I. Uterine anomalies and endometriosis. Minerva Med. 2020; 111(1): 33-49. https://dx.doi.org/10.23736/S0026-4806.19.06341-9.
  52. Киселев В.И., Сидорова И.С., Унанян А.Л., Муйжнек Е.Л. Гиперпластические процессы органов женской репродуктивной системы: теория и практика. Медпрактика-М; 2010. 468 c. [Kiselev V.I., Sidorova I.S., Unanyan A.L., Muizhnek E.L. Hyperplastic processes of the organs of the female reproductive system: theory and practice. Medpraktika-M; 2010. 468p. (in Russian)].
  53. Lin K.Y., Chang C.Y., Lin W.C., Wan L. Increased risk of endometriosis in patients with endometritis - a nationwide cohort study involving 84,150 individuals. Ginekol. Pol. 2020; 91(4): 193-200. https://dx.doi.org/10.5603/GP.2020.0040.
  54. Tai F.W., Chang C.Y., Chiang J.H., Lin W.C., Wan L. Association of pelvic inflammatory disease with risk of endometriosis: a nationwide cohort study involving 141,460 individuals. J. Clin. Med. 2018; 7(11): 379. https://dx.doi.org/10.3390/jcm7110379.
  55. Giampaolino P., Della Corte L., Foreste V., Bifulco G. Is there a relationship between vitamin D and endometriosis? An overview of the literature. Curr. Pharm. Des. 2019; 25(22): 2421-7. https://dx.doi.org/10.2174/1381612825666190722095401.
  56. Ursache A., Lozneanu L., Bujor I.E., Mandici C.E., Boiculese L.V., Bausic A.G. et al. Vitamin D-the iceberg in endometriosis-review and meta-analysis. J. Pers. Med. 2024; 14(1):119. https://dx.doi.org/10.3390/jpm14010119.
  57. Kalaitzopoulos D.R., Samartzis N., Daniilidis A., Leeners B., Makieva S., Nirgianakis K. et al. Effects of vitamin D supplementation in endometriosis: a systematic review. Reprod. Biol. Endocrinol. 2022; 20(1): 176. https://dx.doi.org/10.1186/s12958-022-01051-9.
  58. Kim J.H., Kim S.H. Exposure to phthalate esters and the risk of endometriosis. Dev. Reprod. 2020; 24(2): 71-8. https://dx.doi.org/10.12717/dr.2020.24.2.71.
  59. Cai W., Yang J., Liu Y., Bi Y., Wang H. Association between phthalate metabolites and risk of endometriosis: a meta-analysis. Int. J. Environ. Res. Public Health. 2019; 16(19): 3678. https://dx.doi.org/10.3390/ijerph16193678.
  60. Лизнева Д.В., Синицына А.И. Влияние ксеноэстрогенов, фитоэстрогенов, лекарственных эстрогенов на репродуктивное и соматическое здоровье человека (обзор литературы). Проблемы репродукции. 2012; 4: 16-22. [Lizneva D.V., Sinitsyna A.I. The impact of xenoestrogens, phytoestrogens and pharmaceutical estrogens on human health (a review). Russian Journal of Human Reproduction. 2012; (4):16-22.(in Russian)].
  61. Benagiano G., Brosens I. In utero exposure and endometriosis. J. Matern. Fetal Neonatal Med. 2014; 27(3): 303-8. https://dx.doi.org/10.3109/14767058.2013.814630.
  62. Caporossi L., Capanna S., Viganò P., Alteri A., Papaleo B. From environmental to possible occupational exposure to risk factors: what role do they play in the etiology of endometriosis? Int. J. Environ. Res. Public. Health. 2021; 18(2): 532. https://doi.org/10.3390/ijerph18020532.
  63. Parazzini F., Chiaffarino F., Surace M., Parazzini F., Chiaffarino F., Surace M. et al. Selected food intake and risk of endometriosis. Hum. Reprod. 2004; 19(8): 1755-59. https://dx.doi.org/10.1093/humrep/deh395.
  64. Yamamoto A., Harris H.R., Vitonis A.F., Chavarro J.E., Missmer S.A. A prospective cohort study of meat and fish consumption and endometriosis risk. Am. J. Obstet. Gynecol. 2018; 219(2): 178.e1-178.e10. https://dx.doi.org/10.1016/j.ajog.2018.05.034.
  65. Kechagias K.S., Katsikas Triantafyllidis K., Kyriakidou M., Giannos P.,Kalliala I., Veroniki A.A. et al. The relation between caffeine consumption and endometriosis: an updated systematic review and meta-analysis. Nutrients. 2021; 13(10): 3457. https://dx.doi.org/10.3390/nu13103457.
  66. Schliep K.C., Schisterman E.F., Mumford S.L., Pollack A.Z., Zhang C., Ye A., Stanford J.B. et al. Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle Study. Am. J. Clin.Nutr. 2012; 95(2): 488-97. https://dx.doi.org/10.3945/ajcn.111.021287.
  67. Chiaffarino F., Bravi F., Cipriani S., Parazzini F., Ricci E., Vigano P.et al. Coffee and caffeine intake and risk of endometriosis: a meta-analysis. Eur. J Nutr. 2014; 53(7):1573-9. https://dx.doi.org/10.1007/s00394-014-0662-7.
  68. Радзинский В.Е., Алтухова О.Б. Молекулярно-генетические детерминанты бесплодия при генитальном эндометриозе. Научные результаты биомедицинских исследований. 2018; 4(3): 28-37. [Radzinsky V.E., Altuchova O.B. Molecular-genetic determinants of infertility in genital endometryosis. Research Results in Biomedicine. 2018; 4(3): 28-37. (in Russian)]. https://dx.doi.org/10.18413/2313-8955-2018-4-3-0-3.
  69. Golovchenko I., Aizikovich B., Golovchenko O., Reshetnikov E., Churnosova M., Aristova I. et al. Sex hormone candidate gene polymorphisms are associated with endometriosis. Int. J. Mol. Sci. 2022; 23(22): 13691. https://dx.doi.org/10.3390/ijms232213691.
  70. Christofolini D.M., Mafra F.A., Catto M.C., Bianco B., Barbosa C.P. New candidate genes associated to endometriosis. Gynecol. Endocrinol. 2019; 35(1): 62-5. https://dx.doi.org/10.1080/09513590.2018.1499090.
  71. Ponomarenko M.S., Reshetnikov E.A., Churnosova M.M., Reshetnikova Yu.N., Churnosov V.I., Ponomarenko I.V. Comorbidity and syntropy of benign proliferative diseases of the female reproductive system: non-genetic, genetic, and epigenetic factors (review). Research Results in Biomedicine. 2023; 9(4): 544-56. https://dx.doi.org/10.18413/2658- 6533-2023-9-4-0-9.
  72. Пономаренко И.В., Полоников А.В., Верзилина И.Н., Чурносов М.И. Молекулярно-генетические детерминанты развития эндометриоза. Вопросы гинекологии, акушерства и перинатологии. 2019; 18(1): 82-6. [Ponomarenko I.V., Polonikov A.V., Verzilina I.N., Churnosov M.I. Molecular-genetic determinants of the development of endometriosis. Gynecology, Obstetrics and Perinatology. 2019; 18(1): 82-6. (in Russian)]. https://dx.doi.org/10.20953/1726-1678-2019-1-82-86.

Received 27.04.2024

Accepted 01.07.2024

About the Authors

Tatyana A. Ponomareva, PhD student, Department of Medical and Biological Disciplines, Belgorod National Research University, 308007, Russia, Belgorod, Pobedy str., 85; obstetrician-gynecologist, Belgorod Regional Clinical Hospital of St. Joasaph, 308015, Russia, Belgorod, Nekrasov str., 8/9, rybaarbusova@icloud.com,
https://orcid.org/0009-0007-8533-9319
Oksana B. Altukhova, Dr. Med. Sci., Associate Professor, Head of the Department of Obstetrics and Gynecology, Belgorod National Research University, 308007, Russia, Belgorod, Pobedy str., 85; Head of Gynecological Department, Belgorod Regional Clinical Hospital of St. Joasaph, 308015, Russia, Belgorod, Nekrasov str., 8/9,
altuhova_o@bsu.edu.ru, https://orcid.org/0000-0003-4674-8797
Irina V. Ponomarenko, Dr. Med. Sci., Associate Professor, Department of Medical and Biological Disciplines, Belgorod National Research University,
308007, Russia, Belgorod, Pobedy str., 85, ponomarenko_i@bsu.edu.ru, https://orcid.org/0000-0002-5652-0166
Mikhail I. Churnosov, Dr. Med. Sci., Professor, Head of the Department of Medical and Biological Disciplines, Belgorod National Research University,
308007, Russia, Belgorod, Pobedy str., 85, churnosov@bsu.edu.ru, https://orcid.org/0000-0003-1254-6134
Corresponding author: Tatyana A. Ponomareva, rybaarbusova@icloud.com

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