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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2025№4
Possibility of using microRNA in...

Possibility of using microRNA in non-invasive diagnosis of endometriosis

DOI
https://dx.doi.org/10.18565/aig.2025.23

Yarmolinskaya M.I., Cherkashina S.A., Malysheva O.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia

Due to the high prevalence of endometriosis and its significant negative impact on the reproductive system, quality of life and late diagnosis, there is a clear need to identify new markers for this disease. MicroRNAs are promising biomarkers in non-invasive diagnostis of endometriosis. Their involvement in the pathogenesis of endometriosis has only recently begun to be explored, but microRNAs show promising potential.
This review presents the results of studies on the influence of microRNAs on the occurrence and development of endometriosis, as well as the analysis of their expression in patients with and without this disease. Currently, miR-17-5p, miR-451a and let-7b-5p are the most promising microRNAs for endometriosis diagnosis. The reverse transcription polymerase chain reaction is regarded as the most effective method of detection. Possible biomaterials for non-invasive testing include serum and plasma, saliva and exosomes in the above fluids.
Conclusion: The heterogeneity of the studies presented in this review, variety of test systems used, the differences in methodology, the small number of patients and the lack of a unified research standard, do not allow us to confidently declare any microRNA as a highly specific non-invasive biomarker of endometriosis. It is evident that further research is required to clarify the role of microRNAs in the pathogenesis of endometriosis and their diagnostic capabilities. These findings may contribute to the timely detection and treatment of this disease.

Authors' contributions: Yarmolinskaya M.I., Malysheva O.V., Cherkashina S.A. – developing the concept and design of the study, analysis of data and drawing conclusions; Yarmolinskaya M.I., Cherkashina S.A. – data collection, preparation of the manuscript.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: This work was performed within the Basic Scientific Research FGWN-2025-0004 1024032800068-4-3.2.2.
For citation: Yarmolinskaya M.I., Cherkashina S.A., Malysheva O.V. 
Possibility of using microRNA in non-invasive diagnosis of endometriosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (4): 12-21 (in Russian)
https://dx.doi.org/10.18565/aig.2025.23

Keywords

microRNA
endometriosis
diagnostics
noninvasive markers
PCR
Full text (in Russian)

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Received 05.02.2025

Accepted 23.04.2025

About the Authors

Maria I. Yarmolinskaya, Dr. Med. Sci., Professor of the Russian Academy of Sciences, Head of the Department of Gynecology and Endocrinology, Head of the Center of Diagnostics and Treatment of Endometriosis, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology,
199034, Russia, St. Petersburg, Mendeleevskaya line, 3, m.yarmolinskaya@gmail.com, SPIN-код: 3686-3605, Researcher ID: P-2183-2014, Scopus Author ID: 7801562649, https://orcid.org/0000-0002-6551-4147
Sofya A. Cherkashina, doctor at the Consultative and Diagnostic Department II, D.O. Ott Research institute of Obstetrics, Gynecology and Reproductology,
199034, Russia, St. Petersburg, Mendeleevskaya line, 3, sonyach@list.ru, https://orcid.org/0009-0005-7208-3575
Olga V. Malysheva, PhD (Bio), Senior Researcher at the Laboratory of Genomics, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology,
199034, Russia, St. Petersburg, Mendeleevskaya line, 3, omal99@mail.ru, https://orcid.org/0000-0002-8626-5071
Corresponding author: Maria I. Yarmolinskaya, m.yarmolinskaya@gmail.com

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