Iron deficiency during pregnancy: effectiveness of therapy and key points for clinical practice

Dzhobava E.M., Knysheva I.G., Artizanova D.P.

Crede Experto Clinic LLC, Moscow, Russia
Iron deficiency of varying degrees of severity remains one of the most common complications of pregnancy.
Objective: To present our own experience of using a preparation containing ferrous fumarate and folic acid for the treatment and prevention of iron deficiency in pregnant women during various stages of gestation.
Materials and methods: The study included 90 pregnant women with varying degrees of iron deficiency.
Group 1 included 30 first trimester pregnant women, group 2 consisted of 30 second trimester pregnant women, and group 3 included 30 third trimester pregnant women. All patients took ferrous fumarate in combination with folic acid for 21 days.
Results: The examination revealed a high incidence of diseases of the gastrointestinal tract. The lowest initial indicators of iron concentration were revealed in patients whose gravidity and parity were ≥ 2 (16.6% in group 1, 20% in group 2 and 20% in group 3). Iron deficiency was found most frequently in pregnant women in their third trimester. The most remarkable effect was noted in patients of the 1st and 2nd groups who started therapy at earlier stages of pregnancy in comparison with the patients of the 3rd group. The analysis of hematological and ferrokinetic indicators showed that hemoglobin, serum iron, TIBC, hematocrit increased significantly, and the level of ferritin increased slowly.
Conclusion: The preparation containing ferrous fumarate and folic acid can be effectively used for the prevention and treatment of various stages of iron deficiency during pregnancy starting from the first trimester. Quick and marked positive effect can be obtained by early iron supplementation (including preventive supplementation, pre-latent iron deficiency and latent iron deficiency).

Authors’ contributions: Dzhobava E.M. – writing the article; Knysheva I.G. – editing the article; Artizanova D.P. – collecting and processing the material, data analysis.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The article was prepared without sponsorship.
Patients’ Consent for Publication: All patients signed an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Dzhobava E.M., Knysheva I. G., Artizanova D.P. Iron deficiency during pregnancy: effectiveness of therapy and key points for clinical practice.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (3): 109-112 (in Russian)


iron deficiency
Ferretab сomp


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Received 13.03.2022

Accepted 28.03.2023

About the Authors

Eliso M. Dzhobava, Dr. Med. Sci., Medical Director of the clinic, obstetrician-gynecologist, Crede Experto Clinic,,
Russia, Moscow, Tovarischesky per., 10/1.
Inessa G. Knysheva, PhD, General Director of the clinic, obstetrician-gynecologist, Crede Experto Clinic, Russia, Moscow, Tovarischesky per., 10/1.
Darya P. Artizanova, obstetrician-gynecologist, Crede Experto Clinic, Russia, Moscow, Tovarischesky per., 10/1.

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