Analysis of correlations between the results of diagnostic studies of diseases of the cervix uteri
Objective: To identify relationships between age, cytological and histological findings, colposcopic patterns, and the presence of high-risk human papillomavirus (HPV) in patients with cervical disease.Kazakova A.V., Lineva O.I., Kozupitsa G.S., Chechko S.M., Rustianova D.R.
Materials and methods: The investigation enrolled 50 women aged 23 to 65 years. All the women underwent traditional and liquid-based cervical cytology. Their epithelial cells were scraped and examined for HPV by real-time PCR; their biopsy specimens underwent colposcopy and histology.
Results: There was a high relationship between the histological findings of CIN 3 and CIN 2 and the presence of HPV. The highest likelihood of being diagnosed with CIN 3 was found in HPV types 16 and 18 (52%). There were statistically significant positive correlations between colposcopic diagnosis and histological findings, as well as moderate negative correlations between colposcopic diagnosis and the type of transformation zone and weak negative ones between colposcopic diagnosis and age.
Conclusion: There is a clear relationship between the histological findings of CIN 3 and the presence of HPV types 16 and 18. Colposcopic diagnosis of cervical diseases is most informative under 40 years of age and in the presence of Type I transformation zone.
Keywords
intraepithelial lesion
cytology
colposcopy
HPV
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Received 09.11.2021
Accepted 01.12.2021
About the Authors
Anna V. Kazakova, MD, Dr. Sci. (Med), Head of the Department of Obstetrics and Gynecology No. 2, Samara State Medical University, Ministry of Health of Russia,443099, Russia, Samara, Chapayevskaya str., 89.
Olga I. Lyneva, MD, Dr. Sci. (Med), Professor of the Department of Obstetrics and Gynecology № 2, Samara State Medical University, Ministry of Health of Russia,
443099, Russia, Samara, Chapayevskaya str., 89.
Gennadiy S. Kozupitsa, Dr. Sci. (Bio), Professor of the Department of Physical Education and Sports, Samara State Transport University,
443030, Russia, Samara, Svobody str., 2v.
Svetlana M. Chechko, MD, obstetrician-gynecologist, Department of Operative Gynecology, N.А. Semashko Samara City Clinical Hospital No. 2,
443008, Russia, Samara, Kalinina str., 32.
Daria R. Rustianova, MD, Assistant of the Department of Obstetrics and Gynecology No. 2, Samara State Medical University, Ministry of Health of Russia,
443099, Russia, Samara, Chapayevskaya str., 89.
Corresponding author: Daria R. Rustianova, angel04121993@mail.ru
Authors’ contributions: A.V. Kazakova, O.I. Lineva, G.S. Kozupitsa, S.M. Chechko, D.R. Rustianova – concept and design of the investigation; material collection and processing; writing the text, editing.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The article has been prepared without sponsorship.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Kazakova A.V., Lineva O.I., Kozupitsa G.S., Chechko S.M., Rustianova D.R. Analysis of correlations between the results of diagnostic studies of diseases of the cervix uteri.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 12: 153-158 (in Russian)
https://dx.doi.org/10.18565/aig.2021.12.153-158
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