Analysis of pro- and antioxidant activity in the blood of women with different phenotypes of polycystic ovary syndrome and infertility
Objective. To reveal the specific features of the process of lipid peroxidation in reproductive-aged women with different phenotypes of polycystic ovary syndrome (PCOS).Darenskaya M.A., Kolesnikov S.I., Grebenkina L.A., Danusevich I.N., Lazareva L.M., Nadelyaeva Ya.G., Darzhaev Z.Yu., Nikitina O.A., Bazarova T.A., Kolesnikova L.I.
Subjects and methods. Forty-eight reproductive-aged women with PCOS and infertility were examined and divided into 2 subgroups according to the availability of criteria: 1) classical phenotypes; 2) non-classical phenotypes. Infertile women without PCOS (n = 31) and healthy women (n = 28) were used as comparison groups.
Results. There were statistically significant differences in the examined parameters between the patients with different phenotypes of PCOS. At the same time, in the phenotype subgroups versus the controls and the infertile women without PCOS, the changes were mainly compensatory: slightly decreased superoxide dismutase activity and α-tocopherol concentrations and elevated retinol levels in the classical phenotype group and reduced levels of end thiobarbituric acid-reacting products of lipid peroxidation, increased α-tocopherol concentrations, and lower glutathione levels in the non-classical phenotype subgroup.
Conclusion. In general, in PCOS, and in its classic hyperandrogenic phenotypes in particular, the changes in the lipid peroxidation processes are adaptive in nature, which allows one to recommend a personalized approach to combination treatment of this category of patients.
Keywords
polycystic ovary syndrome
phenotypes
lipid peroxidation
antioxidants
Supplementary Materials
References
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Received 27.10.2016
Accepted 11.11.2016
About the Authors
Darenskaya Marina Alexandrovna, doctor of biological sciences, leading researcher of the laboratory of pathophysiology, Research Center of Family Health and Human Reproduction Problems. 664003, Russia, Irkutsk, Timiryazeva str. 16. Tel.: +73952207636. E-mail: marina_darenskaya@inbox.ruKolesnikov Sergei Ivanovich, Academician of the Russian Academy of Sciences, leading researcher, Research Center of Family Health and Human Reproduction Problems. 664003, Russia, Irkutsk, Timiryazeva str. 16. Tel.: +73952207636. E-mail: iphr@sbamsr.irk.ru.
Grebenkina Lyudmila Anatoljevna, doctor of biological sciences, leading researcher of the laboratory of pathophysiology, Research Center of Family Health and Human Reproduction Problems. 664003, Russia, Irkutsk, Timiryazeva str. 16. Tel.: +73952207636. E-mail: iphr@sbamsr.irk.ru
Danusevich Irina Nikolaevna, doctor of medical sciences, senior researcher of the laboratory of gynecological endocrinology, Research Center of Family Health and Human Reproduction Problems. 664003, Russia, Irkutsk, Timiryazeva str. 16. Tel.: +73952207636. E-mail: iphr@sbamsr.irk.ru
Lazareva Lyudmila, candidate of medical sciences, senior researcher of the laboratory of gynecological endocrinology, Research Center of Family Health and Human Reproduction Problems. 664003, Russia, Irkutsk, Timiryazeva str. 16. Tel.: +73952207636. E-mail: iphr@sbamsr.irk.ru
Nadelyaeva Yana Gennadjevna, candidate of medical sciences, researcher of the laboratory of gynecological endocrinology, Research Center of Family Health and Human Reproduction Problems. 664003, Russia, Irkutsk, Timiryazeva str. 16. Tel.: +73952207636. E-mail: iphr@sbamsr.irk.ru
Darzhaev Zorikto Yurjevich, candidate of medical sciences, head of Human planning and reproduction center, Republican Perinatal Center.
670031, Buryatia Republic, Ulan-Ude, Solnechnaya str. 4A. E-mail: iphr@sbamsr.irk.ru
Nikitina Olga Andreevna, candidate of biological sciences, researcher of the laboratory of pathophysiology, Research Center of Family Health and Human Reproduction Problems. 664003, Russia, Irkutsk, Timiryazeva str. 16. Tel.: +73952207636. E-mail: iphr@sbamsr.irk.ru
Bazarova Tatiana Alexandrovna, researcher of the laboratory of gynecological endocrinology, Research Center of Family Health and Human Reproduction Problems.
664003, Russia, Irkutsk, Timiryazeva str. 16. Tel.: +73952207636. E-mail: iphr@sbamsr.irk.ru
Kolesnikova Lubov Iljinichna, member of Russian Academy of Sciences, professor, doctor of medical sciences, scientific director, Research Center
of Family Health and Human Reproduction Problems. 664003, Russia, Irkutsk, Timiryazeva str. 16. Tel.: +73952207636. E-mail: iphr@sbamsr.irk.ru
For citations: Darenskaya M.A., Kolesnikov S.I., Grebenkina L.A.,
Danusevich I.N., Lazareva L.M., Nadelyaeva Ya.G., Darzhaev Z.Yu., Nikitina O.A.,
Bazarova T.A., Kolesnikova L.I. Analysis of pro- and antioxidant activity in the blood
of women with different phenotypes of polycystic ovary syndrome and infertility.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (8): 86-91. (in Russian)
http://dx.doi.org/10.18565/aig.2017.8.86-91
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