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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
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Obstetrics and Gynegology2021№3
Polycystic ovary syndrome and gut...

Polycystic ovary syndrome and gut microbiota

DOI
https://dx.doi.org/10.18565/aig.2021.3.36-43

Chernukha G.E., Miroshina E.D., Priputnevich T.V.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Polycystic ovary syndrome (PCOS) is a common endocrine disease. Its frequency varies from 6 to 19.9%, depending on the diagnostic criteria used. PCOS is associated with a high risk of type 2 diabetes and cardiovascular disease. The mechanisms for its development are not fully clear; therefore, the relevant issue is to search for the new components of the pathogenesis of the disease, which may predict the development of the pathological process, as well as the predictors for the efficiency of the prescribed therapy. The review presents recent studies establishing an association between the impaired gut microbial composition and the metabolic and clinical manifestations of PCOS. It is supposed that gut dysbiosis may be a potential pathogenetic factor in the development of PCOS, whereas normalization of the gut microbiota may improve the hormonal and metabolic profiles in these patients. The imbalance of useful and harmful intestinal bacteria can lead to increased intestinal wall permeability and the release of toxins into the bloodstream, which causes chronic subclinical inflammation that contributes to the development of insulin resistance, followed by androgen hyperproduction, impaired folliculogenesis, and the development of PCOS. This review considers the new approaches to treating the syndrome, which are aimed at correcting the gut microbiota, subsequently normalizing the hormonal balance, insulin resistance, and restoring the rhythm of menstruation.

Keywords

polycystic ovary syndrome
microbiome
gut microbiota
probiotics
metabolic syndrome
insulin resistance
inflammation
16S rRNA gene sequencing
Full text (in Russian)

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Received 03.07.2020

Accepted 25.11.2020

About the Authors

Galina E. Chernukha, Dr. Med. Sci., Professor, Head of the Department of Gynecological Endocrinology, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. Tel.: +7(985)999-60-00. E-mail: g_chernukha@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Ekaterina D. Miroshina, postgraduate student, Department of endocrinological gynecology, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. Tel.: +7(917)533-48-00. E-mail: emiroshina.md@gmail.com. 117997, Russia, Moscow, Ac. Oparina str., 4.
Tatiana V. Priputnevich, Dr. Med. Sci., Head of the Microbiology, Clinical Pharmacology and Epidemiology Department, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. Tel.: +7(910)414-56-16. E-mail: priput1@gmail.com. 117997, Russia, Moscow, Ac. Oparina str., 4.

For citation: Chernukha G.E., Miroshina E.D., Priputnevich T.V. Polycystic ovary syndrome and gut microbiota.
Akusherstvo i Ginekologiya/ Obstetrics and Gynecology. 2021; 3: 36-43 (in Russian)
https://dx.doi.org/10.18565/aig.2021.3.36-43

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