Potential effect of ovarian puncture in the programmes of in vitro oocyte maturation in women with polycystic ovary syndrome
Karimova A.U., Yanbarisova A.R., Gromenko Iu.Iu., Bagdanova G.M.
Hormonal stimulation and surgical treatment options are used to achieve ovulation in patients with polycystic ovary syndrome (PCOS). However, these methods can result in a number of complications.
Objective: To examine the possible relationship between mechanical impact on the ovary during puncture in in vitro oocyte maturation (IVM) programmes and the occurrence of ovulation in a typical form of PCOS in patients with a history of primary anovulatory infertility.
Materials and methods: The study included eight patients with androgenic phenotype of PCOS, primary anovulatory infertility and history of unsuccessful attempts of monoovulation induction and IVF.
Results: The patients were divided into two groups according to the outcomes of the IVM programmes. Group 1 (n=4) included women who had embryo developmental arrest. Three of them had spontaneous ovulation in the next cycle with subsequent pregnancy. One patient underwent repeated IVM two months after the first programme; a negative hCG result was obtained after transfer of a 3BB embryo; in the next cycle spontaneous ovulation resulted in a spontaneous pregnancy. In group 2, four patients underwent fresh embryo transfers in the IVM protocol (3BC, 2BB, 3BB, and 1B embryos) but no pregnancy occurred. In the next cycle, spontaneous ovulation resulted in uterine pregnancy in one of the patients. The other had 4BC and 3BB embryos left for cryopreservation; there were two transfers of cryopreserved embryos. The patient did not become pregnant. A repeated IVM was performed six months later. In the next cycle, spontaneous ovulation caused the spontaneous pregnancy. The pregnancy of all eight women in both groups proceeded to term, resulting in delivery.
Conclusion: The technique of mechanical ovary treatment appears to show significant potential. The extent of exposure and the potential for bleeding can be effectively managed, and the procedure itself does not result in a decline in ovarian reserve. Additionally, there is no evidence of thermal damage to the ovarian tissue.
Authors' contributions: Karimova A.U., Yanbarisova A.R. – developing the concept and design of the study, writing the text; Gromenko Iu.Iu., Bagdanova G.M. – collecting and processing the material; Gromenko Iu.Iu. – editing. All authors made equal contributions.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Ethical Review Board of the Centre.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
For citation: Karimova A.U., Yanbarisova A.R., Gromenko Iu.Iu., Bagdanova G.M. Potential effect of ovarian puncture in the programmes of in vitro oocyte maturation in women with polycystic ovary syndrome.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (1): 113-116 (in Russian)
https://dx.doi.org/10.18565/aig.2024.53
Keywords
in vitro maturation
IVM
polycystic ovary syndrome
assisted reproductive technologies
follicle puncture
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Received 08.11.2024
Accepted 19.11.2024
About the Authors
Aliya U. Karimova, obstetrician-gynecologist, reproductologist, oncologist, «Family» Medical Center, 450054, Russia, Ufa, Prospekt Oktyabrya str., 73, build. 1,https://orcid.org/0000-0001-5755-5881
Aliya R. Yanbarisova, Resident at the Department of Obstetrics and Gynecology with a course in IDPO, Bashkir State Medical University, Ministry of Health of Russia,
450008, Russia, Ufa, Lenin str. 3, yanbarisova1999@mail.ru, https://orcid.org/0000-0003-3799-4080
Iuliia Iu. Gromenko, PhD, obstetrician -gynecologist, reproductologist, doctor of the highest category, Honored Doctor of the Republic of Bashkortostan and
Russian Federation, Chief Physician, «Family» Medical Center, 450054, Russia, Ufa, Prospekt Oktyabrya str., 73, build. 1, https://orcid.org/0000-0002-3373-0873
Guzal M. Bagdanova, Biologist, Head of the Department of Embryology, «Family» Medical Center, 450054, Russia, Ufa, Prospekt Oktyabrya str., 73, build. 1,
https://orcid.org/0000-0001-7748-5091
Corresponding author: Aliya R. Yanbarisova, yanbarisova1999@mail.ru
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