Comparative assessment of the efficacy of micronized progesterone medications in the IVF programs

Mayasina E.N., Buev Yu.E., Askerov R.A., Yamalyeva N.Sh., Kichigina E.A., Kornilova A.S., Salimov D.F.

Clinical Institute of Reproductive Medicine, Yekaterinburg, Russia

Ovarian stimulation in the in vitro fertilization (IVF) programs is accompanied by a defect in the luteal phase of the cycle, therefore hormonal support after embryo transfer into the uterine cavity is an integral part of the treatment. Vaginal administration is the most common route for the progesterone delivery.
Objective: To compare efficacy and tolerability of two forms of vaginal micronized progesterone, namely capsules (Utrogestan, Besins Healthcare) and gel (Miragel, Vertex JSC), in the IVF programs.
Materials and methods: The study included 309 patients: the patients of the first group (n=154) received micronized progesterone in the form of a vaginal gel at a dose of 90 mg per day, the patients of the second group (n=155) were administered micronized progesterone in capsules 200 mg 3 times a day vaginally. Efficacy was assessed using the following parameters: clinical pregnancy rate, early pregnancy loss rate, live birth rate. The medication tolerability was compared using the assessment of the patients’ questionnaires.
Results: Clinical pregnancy rate in the first group was 59.1%, and it was 55.2% in the second group; early pregnancy loss rate was 14.2% and 15.1%, respectively; live birth rate in the first group was 49.4%, and it was 45.2% in the second group. There were no statistically significant differences between the groups. The rate of premature births in the first group was 0%, and it was 7.1% in the second group. According to the patients’ survey, micronized progesterone in the form of a gel was better tolerated.
Conclusion: The comparative assessment of the vaginal administration of micronized progesterone in the form of gel and capsules demonstrated high efficacy of the medication. The vaginal gel was better tolerated and more convenient for the patients, according to the survey. Miragel can be administered to support the luteal phase in the IVF programs.

Authors’ contributions: Mayasina E.N. – developing the concept and design of the study; Mayasina E.N., Askerov R.A., Buev Yu.E., Yamalyeva N.Sh., Kornilova A.S., Kichigina E.A. – collecting and processing the material; Salimov D.F. – statistical analysis of the data; Askerov R.A. – editing the article.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
Ethical Approval: The study was approved by the Ethical Review Board of the Clinical Institute of Reproductive Medicine, Yekaterinburg.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Mayasina E.N., Buev Yu.E., Askerov R.A., Yamalyeva N.Sh., Kichigina E.A., Kornilova A.S., Salimov D.F. Comparative assessment of the efficacy of  micronized progesterone medications in the IVF programs.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (3): 133-140 (in Russian)


vaginal progesterone gel
luteal phase support
in vitro fertilization
assisted reproductive technologies


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Received 20.02.2024

Accepted 18.03.2024

About the Authors

Elena N. Mayasina, PhD, obstetrician-gynecologist, Deputy General Director, Clinical Institute of Reproductive Medicine, 620014, Russia, Yekaterinburg,
Boris Yeltsin str., 3, office 503, +7(919)381-27-44,,
Yurii E. Buev, Clinical Institute of Reproductive Medicine (Yekaterinburg),,
Roman A. Askerov, Clinical Institute of Reproductive Medicine (Yekaterinburg),,
Naylya Sh. Yamalyeva, Clinical Institute of Reproductive Medicine (Yekaterinburg),,
Ekaterina A. Kichigina, Clinical Institute of Reproductive Medicine (Yekaterinburg),,
Anna S. Kornilova, Clinical Institute of Reproductive Medicine (Yekaterinburg),,
Daniil F. Salimov, Clinical Institute of Reproductive Medicine (Yekaterinburg),,
Corresponding author: Elena N. Mayasina,

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