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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
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Obstetrics and Gynegology2026№1

The essence of preeclampsia and the possibility of its termination

DOI
https://dx.doi.org/10.18565/aig.2025.223

Sidorova I.S., Managadze I.J.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

The etiopathogenetic cause of preeclampsia is currently unknown. In order to address this issue, it is necessary to develop an integrated, interdisciplinary and global approach. What is preeclampsia? What role does the fetus and its brain play in the development of preeclampsia? For the first time in the world, preeclampsia has been considered as a neurogenic neuroimmune conflict between the mother and the fetus after the 22nd week of pregnancy and further, during the formation of the substrate of higher nervous activity and correlates of consciousness in the fetus, the neocortex, in the process of neurocorticogenesis mediated by neuron-specific proteins.
The aim of this article – to present a new perspective on the etiopathogenesis of preeclampsia, to open up potential opportunities for further research by taking into account the key role of the fetal brain, its blood-brain barrier and neuron-specific proteins.
Conclusion: The presented concept reveals the true essence of preeclampsia and radically changes the modern understanding of its etiopathogenesis. It explains scientific facts and experimental data that were not previously scientifically justified, providing the basis for new directions in the search for innovative diagnostic and therapeutic approaches. There is a potential to stop the progression of preeclampsia, prevent severe complications for mothers and babies, and ensure the birth of healthy offspring.

Authors’ contributions: Sidorova I.S. – developing the concept and design of the study, editing the text; Sidorova I.S., Managadze I.J. – collection and analysis of literary data, writing the text.
The authors did not use AI tools to create the text of the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Sidorova I.S., Managadze I.J. The essence of preeclampsia and the possibility of its termination.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (1): 5-11 (in Russian)
https://dx.doi.org/10.18565/aig.2025.223

Keywords

preeclampsia
neurocorticogenesis
neuron-specific proteins
blood-brain barrier
neuroimmune conflict
Full text (in Russian)

References

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Received 20.08.2025

Accepted 26.12.2025

About the Authors

Iraida S. Sidorova, Dr. Med. Sci., Professor, Academician of the RAS, Merited Scholar of the Russian Federation, Merited Doctor of the Russian Federation, Professor at the Department of Obstetrics and Gynecology No. 1 of the N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), 119991, Russia, Moscow, Trubetskaya str., 8 bld. 2, +7 (499) 248-67-29, sidorovais@yandex.ru,
https://orcid.org/0000-0003-2209-8662
Ioanna J. Managadze, resident and PhD student at the Department of Obstetrics and Gynecology No. 1 of the N.V. Sklifosovsky Institute of Clinical Medicine,
I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), 119991, Russia, Moscow, Trubetskaya str., 8, bld. 2, +7(499)248-67-29, ktb1966@mail.ru, https://orcid.org/0000-0001-8745-9372

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